4.7 Review

The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neuroinflammation processes in the Alzheimer's disease continuum

Caterina Motta et al.

Summary: The levels of catecholaminergic enzymes in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) were analyzed. It was found that AD patients had lower levels of dopamine/norepinephrine (DA/NA) innervation markers, but increased levels of dopamine-beta-hydroxylase (D beta H). These findings indicate a close association between catecholaminergic enzymes and the neurodegenerative and neuroinflammatory processes in AD pathology.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Editorial Material Cell Biology

Nilotinib: from animal-based studies to clinical investigation in Alzheimer's disease patients

Annalisa Nobili et al.

NEURAL REGENERATION RESEARCH (2023)

Article Immunology

Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease

Adrianne F. Pike et al.

Summary: This study reveals that dopamine inhibits the activation of NLRP3 inflammasome in primary human microglia, providing insights into the potential therapeutic target for Parkinson's disease.

JOURNAL OF NEUROINFLAMMATION (2022)

Review Pharmacology & Pharmacy

Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease

Hilary Grosso Jasutkar et al.

Summary: This article discusses various approaches to prevent and mitigate alpha-synuclein toxicity in Parkinson's disease, including clearing its aggregates, inhibiting its misfolding and aggregation, reducing its expression level, and enhancing cellular clearance mechanisms. It also discusses the therapeutics in development and the challenges and opportunities in the field.

PHARMACOLOGICAL REVIEWS (2022)

Review Neurosciences

Crosstalk Between the NLRP3 Inflammasome/ASC Speck and Amyloid Protein Aggregates Drives Disease Progression in Alzheimer's and Parkinson's Disease

Jonathan Hulse et al.

Summary: This article provides an in-depth understanding of the interplay between protein aggregation and inflammation in neurodegenerative diseases, and it highlights how these interactions exacerbate disease progression.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Article Neurosciences

Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer's disease mouse model

Elena Spoleti et al.

Summary: This study reveals that impaired cell excitability and firing in ventral CA1 pyramidal neurons is an early feature in Tg2576 AD mice.

EXPERIMENTAL NEUROLOGY (2022)

Article Psychiatry

Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease

Kristi Henjum et al.

Summary: Noradrenergic and dopaminergic neurons play a role in cognitive functions and are associated with behavioral and psychological symptoms in Alzheimer's disease. This study found higher concentrations of noradrenaline and adrenaline, but lower dopamine concentrations in the cerebrospinal fluid of AD patients, and these levels were related to synaptic damage.

TRANSLATIONAL PSYCHIATRY (2022)

Review Neurosciences

The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease

Adrianne F. Pike et al.

Summary: This review suggests a hypothesis that Kv1.3 activity-induced NLRP3 inflammasome activation in microglia may be counteracted by the utilization of dopamine from adjacent dopaminergic neurons, preventing microglial activation. However, as dopamine supply decreases, NLRP3 inflammasome activation and Kv1.3 activity would intensify, leading to the development of the major pathological features of Parkinson's disease.

NPJ PARKINSONS DISEASE (2022)

Article Neurosciences

Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer's disease in Tg2576 mice

Livia La Barbera et al.

Summary: Recent studies have shown that the degeneration of ventral tegmental area (VTA) dopamine neurons in the early stages of Alzheimer's Disease (AD) is associated with impairments in autophagy, leading to accumulation of damaged mitochondria, disturbance in calcium homeostasis, and deterioration of neuron function and structure.

MOLECULAR NEURODEGENERATION (2022)

Review Neurosciences

Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer's disease: Current trends and future perspectives

Livia La Barbera et al.

Summary: Alzheimer's disease is a common form of dementia with unknown primary causes and no definitive cure. Developing novel therapeutic strategies is important for preventing, diagnosing, and treating Alzheimer's disease. Nanomedicine has shown potential in bypassing the blood-brain barrier and improving drug safety and efficacy in Alzheimer's disease management.

FRONTIERS IN NEUROSCIENCE (2022)

Article Neurosciences

Microglia states and nomenclature: A field at its crossroads

Rosa C. Paolicelli et al.

NEURON (2022)

Review Behavioral Sciences

Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies

Ruchi Sharma et al.

Summary: This article presents a comprehensive review on C. pluricaulis, including its plant profile, phytochemistry, neuropharmacological, and toxicological data. The research findings demonstrate that C. pluricaulis exhibits a wide range of neuropharmacological effects and interacts with various proteins and signaling pathways, playing a crucial role in neurotransmission and cognitive function.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2022)

Review Cell Biology

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Md Mominur Rahman et al.

Summary: Glial cells play an important role in neurological diseases and understanding their function is crucial for developing novel therapeutics.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Review Cell Biology

Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Sheikh Shohag et al.

Summary: Free radicals refer to molecules with at least one unpaired electron in their outermost shell. They can be produced within our bodies or by external sources such as ozone, cigarette smoking, and air pollution. Imbalance between reactive oxygen species and antioxidants can lead to various diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. This article aims to provide information on the relationship between oxidative stress and neurodegenerative diseases, and highlights the potential of bioactive substances from medicinal herbs and existing medications in neuroprotective therapy.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Review Pharmacology & Pharmacy

Multifunctional role of natural products for the treatment of Parkinson's disease: At a glance

Md. Mominur Rahman et al.

Summary: Natural substances from plants have been used to treat neurodegenerative disorders like Parkinson's disease (PD). However, conventional treatments for PD have harmful side effects and are expensive. Therefore, new therapeutic strategies that control the mechanisms of neuronal death and dysfunction are needed. Natural resources offer potential treatments, including medicinal herbs, fruits, and vegetables. This research focuses on characterizing the currently available medications for PD and their therapeutic effects targeting diverse pathways.

FRONTIERS IN PHARMACOLOGY (2022)

Article Psychiatry

The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease

Paraskevi Krashia et al.

Summary: Neuropsychiatric symptoms occur in nearly all Alzheimer's Disease patients and have a significant impact on their daily functioning and disease progression. Recent studies have linked dopaminergic deficits in the ventral tegmental area (VTA) to the appearance of these symptoms in patients with mild cognitive impairment and AD. Identifying these deficits early on could potentially serve as a biomarker for early diagnosis and allow for interventions to slow down disease progression.

FRONTIERS IN PSYCHIATRY (2022)

Review Cell Biology

Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: a systematic review

Danko Jeremic et al.

Summary: Alzheimer's disease is the most common neurodegenerative disease in aging population with lack of effective treatments. Accumulation of Aβ peptides is considered one of the fundamental neuropathological pillars of the disease, thus many therapies target Aβ.

AGEING RESEARCH REVIEWS (2021)

Article Neurosciences

Brain Metabolism and Microglia Activation in Mild Cognitive Impairment: A Combined [18F]FDG and [11C]-(R)-PK11195 PET Study

Giacomo Tondo et al.

Summary: This study used PET imaging techniques to investigate the presence of microglial activation in MCI patients, showing an inverse correlation with brain glucose metabolism, suggesting a possible contribution to neurodegeneration.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Neurosciences

Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease

Livia La Barbera et al.

Summary: Recent studies suggest that degeneration of dopaminergic neurons in the Ventral Tegmental Area could be one of the first events in Alzheimer's Disease. Using a mouse model, researchers found that treatment with Nilotinib could reduce phosphorylation of c-Abl, improve autophagy, lower A beta levels, and prevent degeneration of dopaminergic neurons in the VTA. The drug also preserved dopamine outflow to the hippocampus and improved hippocampal-related cognitive functions.

PROGRESS IN NEUROBIOLOGY (2021)

Article Multidisciplinary Sciences

Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from 18F-FDG PET brain persistent homology network

Tun-Wei Hsu et al.

Summary: Dementia is associated with cellular accumulation and neurotransmitter deficiencies, and PHN analysis can be utilized to track neurochemical network evolution in patients at different stages of dementia.

SCIENTIFIC REPORTS (2021)

Review Pharmacology & Pharmacy

Neurodegenerative Disease and the NLRP3 Inflammasome

Jonathan A. Holbrook et al.

Summary: The prevalence of neurodegenerative diseases is increasing, characterized by progressive neuronal loss, protein aggregation, metabolic abnormalities, and immune dysregulation. Research has shown that low-grade systemic inflammation may impact the development and progression of these diseases, and inflammation may also be a causative factor.

FRONTIERS IN PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer's disease

Yesica Gloria et al.

Summary: This study identified early dopaminergic dysfunction in a mouse model of AD, suggesting potential consequences for behavior and cognitive function, and providing insights into future therapeutic strategies.

SCIENTIFIC REPORTS (2021)

Article Clinical Neurology

In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer's disease phases

Arianna Sala et al.

Summary: The study found significant reductions in [123I]FP-CIT binding in both AD-MCI and AD-D patients compared to controls, particularly in the major targets of the ventrotegmental-mesocorticolimbic pathway. Molecular connectivity assessment revealed a widespread loss of inter-connections among subcortical and cortical targets of the mesocorticolimbic network only, highlighting potential therapeutic strategies for AD.

ALZHEIMERS RESEARCH & THERAPY (2021)

Editorial Material Cell Biology

Targeting autophagy as a therapeutic strategy to prevent dopamine neuron loss in early stages of Alzheimer disease

Annalisa Nobili et al.

Summary: Alzheimer's disease is a neurodegenerative disorder without approved medication. Recent research shows that degeneration of dopamine neurons is related to early AD symptoms, with autophagy playing a crucial role in this process. Inhibiting ABL kinase can restore autophagy and prevent neurodegeneration, offering a potential therapeutic target for early AD.

AUTOPHAGY (2021)

Review Immunology

An update on the regulatory mechanisms of NLRP3 inflammasome activation

Seungwha Paik et al.

Summary: This review article discusses the molecular details of NLRP3 inflammasome activation, focusing on priming/licensing and assembly steps, as well as protein-protein interactions, posttranslational modifications, and spatiotemporal regulation of the NLRP3 inflammasome machinery. Multiple positive and/or negative regulatory pathways providing upstream signals for NLRP3 inflammasome complex assembly are also summarized, with the ultimate goal of developing methods for the prevention and treatment of NLRP3 inflammasome-related diseases.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Neurosciences

Ventral Tegmental Area Disconnection Contributes Two Years Early to Correctly Classify Patients Converted to Alzheimer's Disease: Implications for Treatment

Laura Serra et al.

Summary: This study longitudinally investigated VTA disconnection in predicting conversion to AD in a cohort of MCI-AD patients. Results showed that converters exhibited significant reduction of VTA-driven connectivity compared to non-converters, which remained consistent at 24-month follow-up. These findings suggest potential implications for AD staging and prognosis, and support new opportunities for therapeutic interventions.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Review Neurosciences

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease

Mariana Van Zeller et al.

Summary: Alzheimer's disease is a common neurodegenerative disease among the elderly, characterized by neuronal death and cognitive impairment, with chronic inflammation playing a role in its pathophysiology. The NLRP3 inflammasome is implicated in AD pathogenesis and its inhibition may be a potential therapeutic strategy.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Biochemistry & Molecular Biology

Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes

Frances M. Munoz et al.

PURINERGIC SIGNALLING (2020)

Article Neurosciences

In vivo MRI Structural and PET Metabolic Connectivity Study of Dopamine Pathways in Alzheimer's Disease

Leonardo Iaccarino et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

Article Multidisciplinary Sciences

Reduced monoaminergic nuclei MRI signal detectable in pre-symptomatic older adults with future memory decline

Annalena Venneri et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Eunju Lee et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Clinical Neurology

Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside

Rohit Sharma et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2019)

Article Pharmacology & Pharmacy

Neutralization of IL-17 rescues amyloid-β-induced neuroinflammation and memory impairment

Claudia Cristiano et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Editorial Material Neurosciences

Unifying Hypothesis of Dopamine Neuron Loss in Neurodegenerative Diseases: Focusing on Alzheimer's Disease

Paraskevi Krashia et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease

Paraskevi Krashia et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Pharmacological Inhibitors of the NLRP3 Inflammasome

Ayesha Zahid et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Cell Biology

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Marianne O. Klein et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2019)

Review Cell Biology

What role does pyroptosis play in microbial infection?

Xiaojing Xia et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

Inflammasome-mediated innate immunity in Alzheimer's disease

Carmen Venegas et al.

FASEB JOURNAL (2019)

Review Neurosciences

Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease

Carroll Rutherford Fields et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Review Neurosciences

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis

Joachim W. Deitmer et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

Sustained anti-inflammatory effects of TGF-β1 on microglia/macrophages

Afsana Islam et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Biochemistry & Molecular Biology

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

Jialei Zhu et al.

CELL DEATH AND DIFFERENTIATION (2018)

Editorial Material Neurosciences

Ventral Tegmental Area in Prodromal Alzheimer's Disease: Bridging the Gap between Mice and Humans

Marcello D'Amelio et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Clinical Neurology

Tau-targeting therapies for Alzheimer disease

Erin E. Congdon et al.

NATURE REVIEWS NEUROLOGY (2018)

Letter Pharmacology & Pharmacy

Unlocking the secrets of dopamine in Alzheimer's Disease

Marcello D'Amelio et al.

PHARMACOLOGICAL RESEARCH (2018)

Review Pharmacology & Pharmacy

The role of dopaminergic midbrain in Alzheimer's disease: Translating basic science into clinical practice

Marcello D'Amelio et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Clinical Neurology

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

Erik S. Musiek et al.

JAMA NEUROLOGY (2018)

Review Neurosciences

Levodopa in Parkinson's Disease: Current Status and Future Developments

Nicola Tambasco et al.

CURRENT NEUROPHARMACOLOGY (2018)

Article Geriatrics & Gerontology

In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer's disease

Laura Serra et al.

NEUROBIOLOGY OF AGING (2018)

Article Neurosciences

Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine

Yang Fan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Review Clinical Neurology

Neuroimaging Findings Related to Behavioral Disturbances in Alzheimer's Disease: A Systematic Review

Gilberto Sousa Alves et al.

CURRENT ALZHEIMER RESEARCH (2017)

Article Endocrinology & Metabolism

Metabolic connectomics targeting brain pathology in dementia with Lewy bodies

Silvia P. Caminiti et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Review Neurosciences

Therapeutic potential of autophagy-enhancing agents in Parkinson's disease

Tim E. Moors et al.

MOLECULAR NEURODEGENERATION (2017)

Article Multidisciplinary Sciences

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Carmen Venegas et al.

NATURE (2017)

Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

Article Neurosciences

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

Danielle E. Mor et al.

NATURE NEUROSCIENCE (2017)

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Biochemistry & Molecular Biology

The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson's Disease in Rats

Zhijuan Mao et al.

NEUROCHEMICAL RESEARCH (2017)

Article Multidisciplinary Sciences

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease

Lena F. Burbulla et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease

Annalisa Nobili et al.

NATURE COMMUNICATIONS (2017)

Article Immunology

Human Monocytes Engage an Alternative Inflammasome Pathway

Moritz M. Gaidt et al.

IMMUNITY (2016)

Article Biochemistry & Molecular Biology

Neuroinflammation: the devil is in the details

Damon J. DiSabato et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Neurosciences

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease

Marina Saresella et al.

MOLECULAR NEURODEGENERATION (2016)

Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

Article Multidisciplinary Sciences

Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

Kimberly A. Kempadoo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biochemistry & Molecular Biology

Mechanism and Regulation of NLRP3 Inflammasome Activation

Yuan He et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Article Biochemistry & Molecular Biology

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

Yiqing Yan et al.

Article Neurosciences

Interferon-γ-Induced Neurotoxicity of Human Astrocytes

Sadayuki Hashioka et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2015)

Article Endocrinology & Metabolism

De novo expression of dopamine D2 receptors on microglia after stroke

Jojanneke H. J. Huck et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

Inflammasomes: mechanism of action, role in disease, and therapeutics

Haitao Guo et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

Cierra N. Casson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Medicine, General & Internal

Alzheimer's disease

Colin L. Masters et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Neurosciences

Short and Long-term Effects of rTMS Treatment on Alzheimer's Disease at Different Stages: A Pilot Study

Grant Rutherford et al.

JOURNAL OF EXPERIMENTAL NEUROSCIENCE (2015)

Article Neurosciences

The vulnerable ventral tegmental area in Parkinson's disease

Stephanie L. Alberico et al.

BASAL GANGLIA (2015)

Article Biochemistry & Molecular Biology

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

Urte Neniskyte et al.

FEBS LETTERS (2014)

Review Immunology

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Jonathan D. Cherry et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Article Neurosciences

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Colin G. McNamara et al.

NATURE NEUROSCIENCE (2014)

Article Neurosciences

Dopaminergic Modulation of Cortical Plasticity in Alzheimer's Disease Patients

Giacomo Koch et al.

NEUROPSYCHOPHARMACOLOGY (2014)

Review Neurosciences

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

Yu Zhou et al.

PROGRESS IN NEUROBIOLOGY (2014)

Review Geriatrics & Gerontology

Is dopamine involved in Alzheimer's disease?

Alessandro Martorana et al.

FRONTIERS IN AGING NEUROSCIENCE (2014)

Review Cell Biology

Complexity of dopamine metabolism

Johannes Meiser et al.

CELL COMMUNICATION AND SIGNALING (2013)

Article Pharmacology & Pharmacy

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Jean-Luc Martin et al.

CURRENT DRUG TARGETS (2013)

Review Immunology

Caspase-11: The driving factor for noncanonical inflammasomes

Elena Vigano et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

Review Clinical Neurology

Neuronal Vulnerability, Pathogenesis, and Parkinson's Disease

David Sulzer et al.

MOVEMENT DISORDERS (2013)

Article Multidisciplinary Sciences

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka et al.

NATURE (2013)

Article Multidisciplinary Sciences

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Jon A. Hagar et al.

SCIENCE (2013)

Article Clinical Neurology

Neuroprotective effects of donepezil against cholinergic depletion

Debora Cutuli et al.

ALZHEIMERS RESEARCH & THERAPY (2013)

Article Biochemistry & Molecular Biology

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

Vijay A. K. Rathinam et al.

Article Neurosciences

Genomic Analysis of Reactive Astrogliosis

Jennifer L. Zamanian et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Multidisciplinary Sciences

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Geun-Shik Lee et al.

NATURE (2012)

Article Neurosciences

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

Randolph S. Ashton et al.

NATURE NEUROSCIENCE (2012)

Article Clinical Neurology

Neuropsychiatric symptoms in Alzheimer’s disease

Constantine G. Lyketsos et al.

Alzheimers & Dementia (2011)

Article Clinical Neurology

Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients

Giacomo Koch et al.

CLINICAL NEUROPHYSIOLOGY (2011)

Article Multidisciplinary Sciences

Non-canonical inflammasome activation targets caspase-11

Nobuhiko Kayagaki et al.

NATURE (2011)

Article Multidisciplinary Sciences

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Rosa C. Paolicelli et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

The Inflammasomes

Kate Schroder et al.

Review Multidisciplinary Sciences

Regulation of synaptic connectivity by glia

Cagla Eroglu et al.

NATURE (2010)

Review Immunology

Microglial Physiology: Unique Stimuli, Specialized Responses

Richard M. Ransohoff et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Review Clinical Neurology

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

Etienne C. Hirsch et al.

LANCET NEUROLOGY (2009)

Review Microbiology

Pyroptosis: host cell death and inflammation

Tessa Bergsbaken et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Multidisciplinary Sciences

Dopamine Controls Persistence of Long-Term Memory Storage

Janine I. Rossato et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Putting on the Brakes: Cyclic AMP as a Multipronged Controller of Macrophage Function

Marc Peters-Golden

SCIENCE SIGNALING (2009)

Review Neurosciences

Molecular dissection of reactive astrogliosis and glial scar formation

Michael V. Sofroniew

TRENDS IN NEUROSCIENCES (2009)

Article Behavioral Sciences

Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25-35)

Hiroko Tsunekawa et al.

BEHAVIOURAL BRAIN RESEARCH (2008)

Letter Immunology

The NLR gene family: A standard nomenclature

Jenny P. -Y. Ting et al.

IMMUNITY (2008)

Article Neurosciences

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

Cyril Cheret et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury

Julia E. Herrmann et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Immunology

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle et al.

NATURE IMMUNOLOGY (2008)

Article Clinical Neurology

Calcium, ageing, and neuronal vulnerability in Parkinson's disease

D. James Surmeier

LANCET NEUROLOGY (2007)

Article Biochemistry & Molecular Biology

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

T. Fernandes-Alnemri et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Neurosciences

Astrocyte glycogen and brain energy metabolism

Angus M. Brown et al.

Article Multidisciplinary Sciences

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

Joseph A. Duncan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Neurosciences

Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

David Sulzer

TRENDS IN NEUROSCIENCES (2007)

Article Biochemistry & Molecular Biology

Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

Pablo Pelegrin et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Astrocytes: regulation of brain homeostasis via apolipoprotein E

JR Gee et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)

Article Multidisciplinary Sciences

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

A Nimmerjahn et al.

SCIENCE (2005)

Article Neurosciences

Dopamine and noradrenaline control distinct functions in rodent microglial cells

K Färber et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2005)

Article Neurosciences

Reactive astrocytes protect tissue and preserve function after spinal cord injury

JR Faulkner et al.

JOURNAL OF NEUROSCIENCE (2004)

Article Biochemistry & Molecular Biology

The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

SM Srinivasula et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Anatomy & Morphology

Astrocyte-endothelial interactions and blood-brain barrier permeability

NJ Abbott

JOURNAL OF ANATOMY (2002)

Review Cell Biology

Transcriptional regulation by the phosphorylation-dependent factor CREB

B Mayr et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)

Review Immunology

Dopamine, a neurotransmitter, influences the immune system

S Basu et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)