Rhodium-Catalyzed Direct Vinylene Annulation of Sulfoxonium Ylides and N-carbamoylindoles with Vinylene Carbonate

In this study, Rh(III)-catalyzed C-H bifunctionalization and direct vinylene annulation of sulfoxonium ylides and N-carbamoylindoles with vinylene carbonate was accomplished, which afforded a series of naphthalenones containing a beta- ketosulfoxonium ylide moiety, isocoumarins, and pyrimidones. This protocol featured mild conditions, broad substrate scope, and functional-groups compatibility. In addition, related applications and preliminary mechanistic exploratory were also investigated

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In this study, Rh(III)-catalyzed C-H bifunctionalization and direct vinylene annulation of sulfoxonium ylides and N-carbamoylindoles with vinylene carbonate was successfully achieved, resulting in a series of naphthalenones containing a beta-ketosulfoxonium ylide moiety, isocoumarins, and pyrimidones. This protocol offers mild conditions, wide substrate scope, and compatibility with different functional groups. Additionally, related applications and preliminary mechanistic investigations were also conducted.