Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 365, Issue 5, Pages 693-698Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202201135
Keywords
Fluorine; Copper; Indole; Chlorine; Cross-Couping
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The Cu-mediated N-H trifluoroethylation of NH-containing heteroaromatic compounds with CF3CHCl2 (HCFC-123) has been achieved, which is commercially available in industrial scale. This method is applicable to various NH-containing heteroaromatic compounds, including indoles, pyrroles, pyrazoles, and carbazoles. Moreover, this protocol enables the late-stage trifluoroethylation of NH-containing heteroaromatic bioactive molecules.
The Cu-mediated N-H trifluoroethylation of NH-containing heteroaromatic compounds with the CF3CHCl2 (HCFC-123), commercially available in industrial scale, has been achieved. This method can be applied to various NH-containing heteroaromatic compounds including indoles, pyrroles, pyrazoles and carbazoles. Furthermore, this protocol allows the late-stage trifluoroethylation of NH-containing heteroaromatic bioactive-molecules.
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