Palladium-Catalyzed Ring-Opening Diarylation of Cyclobutanols for the Synthesis of Acylindanes

A method for the construction of the indane skeleton through palladium-catalyzed ring-opening diarylation of Cyclobutanols with aryl 1,2-dihalides has been described. The ring-expansion reaction involves beta-carbon elimination of Cyclobutanols and subsequent alpha-carbon arylation of ketone to give 2-acylindanes in 42-93% yields.

Automated summary

A method for constructing the indane skeleton was described, involving a palladium-catalyzed ring-opening diarylation of Cyclobutanols with aryl 1,2-dihalides. The reaction proceeds through beta-carbon elimination and subsequent alpha-carbon arylation of ketone, resulting in the formation of 2-acylindanes in yields of 42-93%.