4.7 Article

Synthesis of Anilides by Aminolysis of Unactivated Esters using MnCl2 in Combination with strong Bases as Catalyst

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 365, Issue 11, Pages 1794-1800

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202300285

Keywords

Amidation; Ester; Anilides; Manganese; Catalysis

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In this study, we report an aminolysis reaction of aromatic and alkyl esters with anilines catalyzed by a readily available catalytic system comprising of an earth-abundant Mn-salt in combination with an inexpensive base.
Anilides are often found in pharmaceuticals and active ingredients in crop protection. Although of great interest, the atom- and step economic formation of the amide bond between a less nucleophilic aniline with an acid or ester remains still a major challenge. Herein, we report an aminolysis of aromatic and alkyl esters with anilines catalyzed by a readily available catalytic system comprising of an earth-abundant Mn-salt in combination with an inexpensive base.

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