Journal
CELLULAR SIGNALLING
Volume 27, Issue 4, Pages 729-738Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.11.038
Keywords
Hepatic apoptosis; Nuclear factors; Foxa2; NF-kappa B; C/EBP beta; p53
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Apoptosis is a prominent characteristic in the pathogenesis of liver disease. The mechanism of hepatic apoptosis is not well understood. Hepatic apoptosis alters relative levels of nuclear factors such as Foxa2, NF-kappa B, C/EBP beta, and p53. Regulation of nuclear factors modulates the degree of hepatic apoptosis and the progression of liver disease. Nuclear factors have distinctive mechanisms to mediate hepatic apoptosis. The modification of nuclear factors is a novel therapeutic strategy for liver disease as demonstrated by pre-clinical models and clinical trials. (c) 2014 Elsevier Inc. All rights reserved.
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