Reallocating Cell Respiration Substrates for Cancer Therapy Using a Metabolism Regulator with an Intermembrane-Translocatable Accessory

Article Nanoscience & Nanotechnology

Dual Inhibitions on Glucose/Glutamine Metabolisms for Nontoxic Pancreatic Cancer Therapy

Yingying Xu et al.

Summary: The new strategy of dual inhibition on glucose and glutamine metabolisms by silencing mutated gene Kras and glutaminase 1 (GLS1) via nanomaterial-based siKras and siGLS1 delivery can enhance pancreatic cancer treatment efficacy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy

Xiangyu Meng et al.

Summary: An intelligent nanomedicine based on glucose deprivation and glycolysis inhibition was created for enhanced cancer synergistic treatment. The nanomedicine effectively blocks glycolysis and depletes glucose, leading to cancer cell apoptosis and growth suppression.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Physical

Dual inhibition of glycolysis and oxidative phosphorylation by aptamer-based artificial enzyme for synergistic cancer therapy

Xiao Fang et al.

Summary: In this study, an aptamer-based artificial enzyme was developed to simultaneously inhibit glycolysis and oxidative phosphorylation (OXPHOS) in cancer cells. The artificial enzyme, called AptCCN, can capture intracellular arginine and catalyze its oxidation to nitric oxide (NO) under red light irradiation. In vitro and in vivo experiments demonstrated that this strategy effectively blocked energy supply and induced apoptosis in cancer cells.

NANO RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Biocatalytic Depletion of Tumorigenic Energy Sources Driven by Cascade Reactions for Efficient Antitumor Therapy

Ya-Ping Xiao et al.

Summary: Researchers have developed a cascade catalytic system based on FP that can simultaneously deprive tumors of glucose and lactate while providing oxygen supply. The system shows promise for effective antitumor therapy under the guidance of photoacoustic imaging.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Nanoscience & Nanotechnology

Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

Zhiyan Li et al.

Summary: This article introduces the application of nanomaterial-assisted starvation treatment in cancer therapy. By elaborating on the interactions between different treatment mechanisms, this method can address the limitations of traditional treatments. The obstacles and potential for advancing these anticancer therapies are also highlighted in this review.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Chemistry, Multidisciplinary

A Nanounit Strategy Disrupts Energy Metabolism and Alleviates Immunosuppression for Cancer Therapy

Yang Luo et al.

Summary: Aberrant energy metabolism in tumors not only promotes cell proliferation but also inhibits antitumor immunity. A novel metabolic nanoregulator was developed to cut off energy supply and improve immune suppression, enabling synergistic tumor starvation-immunotherapy.

NANO LETTERS (2022)

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Article Multidisciplinary Sciences

Brown-fat-mediated tumour suppression by cold-altered global metabolism

Takahiro Seki et al.

Summary: Exposure to cold conditions inhibits the growth of various types of solid tumors by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells. Cold exposure also reduces glucose uptake in tumor tissue. These findings provide a new concept and paradigm for cancer therapy using a simple and effective approach.

NATURE (2022)

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Article Chemistry, Multidisciplinary

A Smart Nanoreactor Based on an O2-Economized Dual Energy Inhibition Strategy Armed with Dual Multi-stimuli- Responsive Doorkeepers for Enhanced CDT/ PTT of Rheumatoid Arthritis

Shang Qiu et al.

Summary: This study developed a novel therapeutic approach based on an intelligent co-delivery system that targets RA-FLS cells, providing treatment effects including controlled drug release through multi-stimuli response, along with enhanced efficacy through chemodynamic and photothermal therapy.

ACS NANO (2022)

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Editorial Material Oncology

Cold exposure as anti-cancer therapy

Mariia Yuneva

Summary: Increasing glucose catabolism in brown adipose tissue through cold exposure reduces blood glucose and insulin tolerance, thereby decreasing glucose catabolism in tumors and arresting tumor progression, providing a novel approach for metabolism-based cancer therapy.

CANCER CELL (2022)

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Review Medicine, Research & Experimental

Digging deeper through glucose metabolism and its regulators in cancer and metastasis

Majid Ghanavat et al.

Summary: Glucose metabolism enzymes and transporters play a significant role in cancer development and metastasis. Aerobic glycolysis is observed as the most favorable mechanism for glucose metabolism in cancer cells. Lactate, lactate dehydrogenase, and monocarboxylic transporter serve as potential biomarkers, therapeutic targets, and diagnostic tools for cancer and metastasis.

LIFE SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

Zhan Zhang et al.

Summary: The constructed nanocomplex can remodel the immunosuppressive tumor microenvironment and achieve effective inhibition of tumors through sonodynamic therapy, while alleviating tumor hypoxia and acidic environment.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy

Wei Sang et al.

Summary: A oxygen-enriched X-ray nanoprocessor nanoparticle has been developed for improving the therapeutic effect of radiotherapy and radiodynamic therapy in combination with immunotherapy, aiming to modulate hypoxia tumor microenvironment and promote antitumor immune response.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Nanoparticle-Stabilized Oxygen Microcapsules Prepared by Interfacial Polymerization for Enhanced Oxygen Delivery

Baiheng Wu et al.

Summary: A new oxygen delivery system using polydopamine-nanoparticle-stabilized oxygen microcapsules has been developed to target tumor hypoxia and suppress tumor growth. The microcapsules demonstrate excellent biocompatibility and have the ability to increase and maintain oxygen levels in the tumor microenvironment, leading to improved outcomes both in vitro and in vivo. Synergetic therapy combining oxygen microcapsules with gemcitabine drugs shows the best performance in inhibiting tumor growth.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

A Versatile Calcium Phosphate Nanogenerator for Tumor Microenvironment-activated Cancer Synergistic Therapy

Lian-Hua Fu et al.

Summary: The GCAH nanotheranostic system is targeted towards cancer cells with overexpressed glycoprotein CD44, utilizing glucose oxidase (GOx) as a biotemplate and modifying it with l-Arginine (L-Arg) and hyaluronic acid (HA). It effectively depletes glucose nutrients in the tumor region through GOx-triggered glucose oxidation and enhances gas therapy by oxidizing L-Arg into NO under the acidic tumor microenvironment. The synergistic therapeutic effect of starvation therapy and gas therapy is significant without toxic side effects in 4T1 tumor-bearing mice.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer

Ran Li et al.

Summary: The study demonstrates that the accumulation of nanoparticle albumin bound paclitaxel in tumors is influenced by signaling molecules related to nutrient uptake and processing, which can be reprogrammed to enhance the drug's efficacy.

NATURE NANOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Mitochondria Targeted O2 Economizer to Alleviate Tumor Hypoxia for Enhanced Photodynamic Therapy

Ping Yuan et al.

Summary: In this study, a mitochondria targeted O-2 economizer (Mito-OxE) was developed to improve the efficiency of photodynamic therapy by alleviating tumor hypoxia and enhancing the subcellular localization of photosensitizers. The targeted drug delivery system shows promising results in enhancing PDT efficacy against hypoxic tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites

Parbeen Singh et al.

Summary: A simple formulation of glucose-oxidase-coated CuS nanoparticles has shown high effectiveness in melanoma treatment, utilizing a synergistic combination of glucose starvation, photothermal therapy, and advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions enhanced by endogenous chloride.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Nanoparticle-Mediated Inhibition of Mitochondrial Glutaminolysis to Amplify Oxidative Stress for Combination Cancer Therapy

Lei Xu et al.

Summary: This study developed a nanoparticle platform targeting tumor cells for effective breast cancer therapy by inhibiting mitochondrial glutaminolysis and employing chemodynamic therapy. The approach involves targeting and releasing specific substances to disrupt tumor cell metabolism and redox balance, ultimately inhibiting tumor growth.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Photosynthetic Cyanobacteria-Hybridized Black Phosphorus Nanosheets for Enhanced Tumor Photodynamic Therapy

Fenggang Qi et al.

Summary: This study utilizes two-dimensional black phosphorus modified photosynthetic cyanobacteria to continuously generate oxygen at tumor sites, and then uses photosensitizers to activate oxygen into singlet oxygen, resulting in a strong tumor cell killing effect.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform

Jiantao Yu et al.

Summary: Recent research has shown that lactate is a major energy source for cells, prompting the development of a new strategy for cancer starvation therapy involving dual deprivation of lactate and glucose. Nanoplatforms are used to co-deliver CHC and GOx in order to achieve this, resulting in enhanced anti-tumor effects both in vitro and in vivo.

ADVANCED SCIENCE (2021)

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Article Multidisciplinary Sciences

Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy

Yu Huang et al.

Summary: A biomimetic multiarm nanovesicle designed through bioinspired methods can efficiently deliver tPA and target thrombolysis at the site of thrombus with high selectivity and efficacy. Additionally, a novel computational model is capable of simulating thrombolysis process and has potential application in predicting thrombolysis dynamics in physiological scenarios.

SCIENCE ADVANCES (2021)

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Review Materials Science, Biomaterials

Regulating glucose metabolism using nanomedicines for cancer therapy

Ming Tang et al.

Summary: Regulation of glucose metabolism is a key focus in cancer treatment, with recent progress showing potential for efficient cancer therapy by manipulating this pathway using nanomedicines. Research has advanced in understanding cell energy supply, tumor resistance strategies, and the development of multifunctional nanoagents through glucose metabolism regulation.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

Supramolecular nanovesicles for synergistic glucose starvation and hypoxia-activated gene therapy of cancer

Ludan Yue et al.

Summary: Glucose starvation has been used as a therapeutic strategy to inhibit tumor growth by regulating glucose metabolism, but the hypoxic tumor microenvironment can limit its efficacy. This study developed a dual-lock supramolecular nanomedicine system for synergistic cancer therapy, integrating glucose oxidase-induced starvation and hypoxia-activated gene therapy. The system showed integrated therapeutic effects in vitro and in vivo for tumor suppression, through the controlled release of glucose oxidase and activation of the therapeutic gene in response to cancer-specific reactive oxygen species.

NANOSCALE (2021)

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Review Endocrinology & Metabolism

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

Peter Kreuzaler et al.

MOLECULAR METABOLISM (2020)

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Article Chemistry, Multidisciplinary

Enzyme-Mediated Tumor Starvation and Phototherapy Enhance Mild-Temperature Photothermal Therapy

Ge Gao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy

Minfeng Huo et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Self-Delivery Nanomedicine for O2-Economized Photodynamic Tumor Therapy

Lin-Ping Zhao et al.

NANO LETTERS (2020)

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Article Materials Science, Multidisciplinary

Programmable starving-photodynamic synergistic cancer therapy

Leli Zeng et al.

SCIENCE CHINA-MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Programmable NIR-II Photothermal-Enhanced Starvation-Primed Chemodynamic Therapy using Glucose Oxidase-Functionalized Ancient Pigment Nanosheets

Chen Yang et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal

Ya-Xuan Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration

David Kolb et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

3-Bromopyruvate-Conjugated Nanoplatform-Induced Pro-Death Autophagy for Enhanced Photodynamic Therapy against Hypoxic Tumor

Yongyan Deng et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

A Glucose/Oxygen-Exhausting Nanoreactor for Starvation- and Hypoxia-Activated Sustainable and Cascade Chemo-Chemodynamic Therapy

Yuxin Guo et al.

SMALL (2020)

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Review Chemistry, Multidisciplinary

Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

Menghong Xu et al.

NANOSCALE (2020)

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Article Pharmacology & Pharmacy

A Mitochondria-Driven Metabolic Sensing Nanosystem for Oxygen Availability and Energy Blockade of Cancer

Shuang-Shuang Wan et al.

ADVANCED THERAPEUTICS (2020)

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Article Oncology

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Choh Yeung et al.

CANCER RESEARCH (2019)

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Article Chemistry, Multidisciplinary

Modulation of Intracellular Oxygen Pressure by Dual-Drug Nanoparticles to Enhance Photodynamic Therapy

Ya-Tong Fan et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy

Lian-Hua Fu et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Glucose Oxidase-Instructed Multimodal Synergistic Cancer Therapy

Lian-Hua Fu et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

Yifan Zhang et al.

MATERIALS HORIZONS (2019)

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Article Biophysics

Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer

Zhuo Lv et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2018)

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Review Cell Biology

Understanding the diversity of membrane lipid composition

Takeshi Harayama et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Chemistry, Multidisciplinary

Erythrocyte Membrane Cloaked Metal-Organic Framework Nanoparticle as Biomimetic Nanoreactor for Starvation-Activated Colon Cancer Therapy

Lu Zhang et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Interfering with Lactate-Fueled Respiration for Enhanced Photodynamic Tumor Therapy by a Porphyrinic MOF Nanoplatform

Zhao-Xia Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Review Radiology, Nuclear Medicine & Medical Imaging

Diagnostic Role of Fluorodeoxyglucose PET in Breast Cancer A History to Current Application

Dhritiman Chakraborty et al.

PET CLINICS (2018)

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Article Chemistry, Multidisciplinary

Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy

Wenpei Fan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Chemistry, Multidisciplinary

Fluorescence studies on the interaction between chlorpromazine and model cell membranes

Yao-Wen Jiang et al.

NEW JOURNAL OF CHEMISTRY (2017)

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Article Nanoscience & Nanotechnology

Glucose Oxidase-Polymer Nanogels for Synergistic Cancer-Starving and Oxidation Therapy

Wenguo Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Oncology

Aberrant cancer metabolism in epithelial-mesenchymal transition and cancer metastasis: Mechanisms in cancer progression

Run Huang et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2017)

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Article Chemistry, Multidisciplinary

Overcoming the Heat Endurance of Tumor Cells by Interfering with the Anaerobic Glycolysis Metabolism for Improved Photothermal Therapy

Wei-Hai Chen et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

In Situ Visualization of Lipid Raft Domains by Fluorescent Glycol Chitosan Derivatives

Yao-Wen Jiang et al.

LANGMUIR (2016)

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Article Multidisciplinary Sciences

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Thomas M. Ashton et al.

NATURE COMMUNICATIONS (2016)

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Review Oncology

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Nissim Hay

NATURE REVIEWS CANCER (2016)

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Review Immunology

Targeting glucose metabolism for cancer therapy

Robert B. Hamanaka et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

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Review Oncology

Cancer Cell Metabolism: One Hallmark, Many Faces

Jason R. Cantor et al.

CANCER DISCOVERY (2012)

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Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

Yuhua Zhao et al.

CANCER RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Giant Vesicles: Preparations and Applications

Peter Walde et al.

CHEMBIOCHEM (2010)

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Article Biophysics

AC-electric field dependent electroformation of giant lipid vesicles

Timothy J. Politano et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2010)

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Redistribution of intracellular oxygen in hypoxia by nitric oxide:: Effect on HIF1α

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SCIENCE (2003)

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Reallocating Cell Respiration Substrates for Cancer Therapy Using a Metabolism Regulator with an Intermembrane-Translocatable Accessory

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