Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 33, Issue 16, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202212231
Keywords
chitosan; cryogels; expandable hemostat; non-compressible hemorrhage; shape recovery
Ask authors/readers for more resources
A cryogelation strategy and subsequent solvent exchange were developed for the production of fast expandable chitosan cryogel. The cryogel demonstrated rapid shape recovery and high water absorption ability. It was also shown to have positive effects on in situ tissue regeneration due to its biodegradability and biocompatibility. Therefore, chitosan cryogels prepared by this simple method could effectively control noncompressible bleeding and severe high-pressure hemorrhage.
Hemorrhage control, especially noncompressible wound hemostasis, is a tremendous challenge in military injuries and other traumas worldwide. Here, a cryogelation strategy and subsequent solvent exchange are developed for the hydrogen bond-induced self-assembly of chitosan fibers and the production of fast expandable chitosan cryogel. Importantly, the ambient drying process facilitates the repeatable deformation performance of the shape-memory cryogel with a response time of approximate to 1.7 s. Due to the capillary-like structure of the cryogel and high hydrophilicity, rapid shape recovery is accompanied by 41 times water absorption ability. It is further demonstrated that chitosan cryogel is beneficial for in situ tissue regeneration by taking advantage of the biodegradability and biocompatibility of chitosan. Thus, chitosan cryogels prepared by this simple and benign method should have efficient hemostatic effect on noncompressible bleeding and severe fatal high-pressure hemorrhage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available