Diastereodivergent Construction of Bicyclic γ-Lactones via Enantioselective Ketone Hydroacylation

We present a diastereodivergent strategy for constructing bicyclic gamma-lactones bearing quaternary carbon centers via ketone hydroacylation. By applying a Rh catalyst and JoSPOphos ligand, either the anti or syn bicyclic gamma-lactones can be accessed with high enantio- and diastereoselectivities, depending on the choice of solvent, temperature, and counterion.