Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 35, Pages 11077-11080Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b04477
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Funding
- U.S. National Science Foundation [CHE-1307404]
- Binational Science Foundation [2014116]
- U.S. National Institutes of Health [ES016865, GM065307, CA158191]
- Office of Science (BER) of the U.S. Department of Energy [DE-FG02-08ER64568]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1307404] Funding Source: National Science Foundation
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We show that copper-containing metal organic nanoparticles (MONPs) are readily synthesized via Cu(II)-mediated intramolecular cross-linking of aspartate-containing polyolefins in water. In situ reduction with sodium ascorbate yields Cu(I)-containing MONPs that serve as highly efficient supramolecular catalysts for alkyne azide click chemistry reactions, yielding the desired 1,4-adducts at low parts per million catalyst levels. The nanoparticles have low toxicity and low metal loadings, making them convenient, green catalysts for alkyne azide click reactions in water. The Cu-MONPs enter cells and perform efficient, biocompatible click chemistry, thus acting as intracellular nanoscale molecular synthesizers.
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