Journal
ACTA OPHTHALMOLOGICA
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/aos.15722
Keywords
multiple sclerosis; deep learning; optical coherence tomography; retinal ganglion cell layer
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The purpose of this study is to develop a computer-aided method for the diagnosis and prognosis of multiple sclerosis (MS) by measuring the thickness of the macular ganglion cell layer. By applying deep learning techniques, it is possible to accurately diagnose MS and predict the course of the disease.
Purpose The macular ganglion cell layer (mGCL) is a strong potential biomarker of axonal degeneration in multiple sclerosis (MS). For this reason, this study aims to develop a computer-aided method to facilitate diagnosis and prognosis in MS.Methods: This paper combines a cross-sectional study of 72 MS patients and 30 healthy control subjects for diagnosis and a 10-year longitudinal study of the same MS patients for the prediction of disability progression, during which the mGCL was measured using optical coherence tomography (OCT). Deep neural networks were used as an automatic classifier.Results: For MS diagnosis, greatest accuracy (90.3%) was achieved using 17 features as inputs. The neural network architecture comprised the input layer, two hidden layers and the output layer with softmax activation. For the prediction of disability progression 8 years later, accuracy of 81.9% was achieved with a neural network comprising two hidden layers and 400 epochs.Conclusion: We present evidence that by applying deep learning techniques to clinical and mGCL thickness data it is possible to identify MS and predict the course of the disease. This approach potentially constitutes a non-invasive, low-cost, easy-to-implement and effective method.
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