Journal
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Volume 102, Issue 7, Pages 811-820Publisher
WILEY
DOI: 10.1111/aogs.14577
Keywords
allergy; antibiotics; cesarean section; immune system; intestinal microbiota; microbiome
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With the increasing rates of cesarean section and the use of pre-incision antibiotics, neonatal exposure to antibiotics before birth is higher than ever. This review examines the protocols for intrapartum prophylactic antibiotics in cesarean section, the impact on neonatal intestinal microbiota, and the potential link to the development of allergic disease.
With increasing rates of cesarean section worldwide and international guidelines advising pre-incision antibiotics, neonatal exposure to pre-birth antibiotics is higher than ever before. Emerging evidence has raised concern regarding the impact of such antibiotics on the neonatal intestinal microbiota, immune system development and health conditions later in life. This narrative review investigates current protocols for intrapartum prophylactic antibiotics in cesarean section, how this and other factors may affect the neonatal intestinal microbiota and whether intrapartum antibiotics used for cesarean section are linked to the development of allergic disease.
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