Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 8, Pages 2536-2539Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b00053
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- Office of Basic Energy Sciences of the U.S. Department of Energy [DE-FG02-13ER16369]
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A stable and isolable difluoromethyl zinc reagent has been prepared through the reaction of ICF2H with diethyl zinc and DMPU. This new zinc reagent is a free-flowing solid and can be used in combination with a nickel catalyst to difluoromethylate aryl iodides, bromides, and triflates at room temperature. Such mild conditions for the catalytic difluoromethylation of these substrates are unprecedented.
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