4.8 Article

Water-Soluble Chemically Precise Fluorinated Molecular Clusters for Interference-Free Multiplex 19F MRI in Living Mice

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation

Cheng Zhang et al.

Summary: This review discusses the applications of fluorinated molecules in bioengineering and nanotechnology, with a focus on controlling fluorine-fluorine interactions and understanding their impact on biological behavior. The controlled introduction of fluorine and its interactions can provide advantages in imaging, therapeutics, and environmental applications.

CHEMICAL REVIEWS (2022)

Article Engineering, Biomedical

Fluorinated Ionic Liquid Based Multicolor 19F MRI Nanoprobes for In Vivo Sensing of Multiple Biological Targets

Xianglong Zhu et al.

Summary: This study presents a versatile model of activatable probes for multicolor F-19 MRI based on fluorinated ionic liquids, loaded in nanocarriers and sealed by stimuli-sensitive copolymers. It allows non-invasive detection of tumor hallmarks by distinguishing individual colors in living organisms, offering a new realm in mechanistic understanding of complex pathophysiologic processes in vivo.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

An Osimertinib-Perfluorocarbon Nanoemulsion with Excellent Targeted Therapeutic Efficacy in Non-small Cell Lung Cancer: Achieving Intratracheal and Intravenous Administration

Jie Yang et al.

Summary: Low accumulation of anticancer drugs in tumors and serious systemic toxicity are still major challenges in pharmaceuticals. Pulmonary delivery of nanoscale-based drug delivery systems offers a strategy to increase antitumor activity with minimal adverse exposure. In this study, we report an osimertinib-loaded nanoemulsion system that synergizes with F-19 MRI-guided LIFU for lung cancer therapy. The research validates the potential of this nanoemulsion system for lung cancer treatment, achieving quick distribution and drug release without severe side effects.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Redox-Activated Contrast-Enhanced T1-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver

Kun Liu et al.

Summary: The study introduces a novel type of nanomaterial as redox-activated probes for real-time visualization of GSH-mediated liver biotransformation using MRI. The technique reveals periodic variations in GSH concentration during the degradation of the nanoparticles, providing direct imaging evidence for carrier-mediated processes in GSH metabolism. This methodology offers a feasible means for in-depth investigations of GSH-related biological processes in liver and real-time assessment of liver functions for early diagnosis of diseases and toxicity evaluation of pharmaceuticals.

ACS NANO (2021)

Article Chemistry, Analytical

Activatable Multiplexed 19F Magnetic Resonance Imaging Visualizes Reactive Oxygen and Nitrogen Species in Drug-Induced Acute Kidney Injury

Ao Li et al.

Summary: The development of two activatable F-19 magnetic resonance imaging (MRI) molecular probes with different F-19 chemical shifts allows for simultaneous in vivo detection and deep-tissue imaging of O-2(center dot-) and ONOO-. This technique shows potential for background-free real-time imaging of diverse biological processes, accurate diagnosis of various diseases in deep tissues, and rapid toxicity evaluation of assorted drugs.

ANALYTICAL CHEMISTRY (2021)

Article Nanoscience & Nanotechnology

Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging

Juan Manuel Arango et al.

Summary: A novel fluorine labeling strategy was proposed in this study, which successfully synthesized potential fluorinated nanoparticles through conjugation of small fluorinated building blocks with gold nanoparticles. These nanoparticles exhibited potential applications in biological imaging in vivo using F-19 magnetic resonance spectroscopy in mice.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Multidisciplinary Sciences

Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders

Ulrich Floegel et al.

Summary: The study introduces a multi-color, multi-targeted non-invasive imaging technology for predicting silent danger patterns prior to myocardial infarction in mice. By using a nanoemulsion platform technology, evolving danger patterns of coronary inflammation and atherothrombosis can be visualized simultaneously.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects

Hongyu Lin et al.

Summary: F-19 MRI serves as an exceptional complement to H-1 MRI, offering high sensitivity, low biological background, and a wide range of chemical shifts. When combined with activatable nanoprobes, the specificity and sensitivity of F-19 MRI can be further enhanced, allowing for in vivo detection and imaging at cellular or even molecular level in deep tissues.

ADVANCED MATERIALS (2021)

Review Chemistry, Multidisciplinary

Emergent Fluorous Molecules and Their Uses in Molecular Imaging

Chao Wang et al.

Summary: This Account summarizes recent advances in the chemistry of fluorocarbon nanoemulsion functionalization, describing new families of fluorous molecules soluble in FC oils and their applications in in vivo molecular imaging. It also discusses the challenges of fluorocarbon functionalization, the development of fluorous chelators for multimodal imaging agents, and the use of fluorophores and cell-penetrating peptides in NE formulations to enhance detection sensitivity.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Article Chemistry, Multidisciplinary

Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes

Ao Li et al.

Summary: The development of peroxynitrite-responsive self-assembled F-19 MRI nanoprobes enables sensitive imaging of peroxynitrite in cells under oxidative stress and living mice with DILI.

CHEMICAL COMMUNICATIONS (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

An iterative sparse deconvolution method for simultaneous multicolor 19F-MRI of multiple contrast agents

Jasper Schoormans et al.

MAGNETIC RESONANCE IN MEDICINE (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Cell penetrating peptide functionalized perfluorocarbon nanoemulsions for targeted cell labeling and enhanced fluorine-19 MRI detection

Dina V. Hingorani et al.

MAGNETIC RESONANCE IN MEDICINE (2020)

Review Chemistry, Multidisciplinary

19F Magnetic Resonance Activity-Based Sensing Using Paramagnetic Metals

Da Xie et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

Article Chemistry, Multidisciplinary

Low-Fouling Fluoropolymers for Bioconjugation and In Vivo Tracking

Changkui Fu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators

Chengjie Sun et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

Article Chemistry, Physical

Nanoparticles for two color 19F magnetic resonance imaging: Towards e combined imaging of biodistribution and degradation

Olga Koshkina et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

Article Nanoscience & Nanotechnology

Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

Max L. Senders et al.

NATURE NANOTECHNOLOGY (2020)

Article Chemistry, Multidisciplinary

Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and19F NMR Detection

Giulia Neri et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Article Engineering, Biomedical

In vivo clearance of 19F MRI imaging nanocarriers is strongly influenced by nanoparticle ultrastructure

Alexander H. J. Staal et al.

BIOMATERIALS (2020)

Article Chemistry, Multidisciplinary

Reversible redox-responsive H-1/F-19 MRI molecular probes

Hongming Chen et al.

CHEMICAL COMMUNICATIONS (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Multispectral MRI with Dual Fluorinated Probes to Track Mononuclear Cell Activity in Mice

Cristina Chirizzi et al.

RADIOLOGY (2019)

Article Chemistry, Multidisciplinary

Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes

Amin Haghighat Jahromi et al.

ACS NANO (2019)

Review Chemistry, Multidisciplinary

Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging

Zijian Zhou et al.

ADVANCED MATERIALS (2019)

Review Chemistry, Multidisciplinary

Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

Jessica Wahsner et al.

CHEMICAL REVIEWS (2019)

Article Nanoscience & Nanotechnology

β-Diketonate-Iron(III) Complex: A Versatile Fluorine-19 MRI Signal Enhancement Agent

Chao Wang et al.

ACS APPLIED BIO MATERIALS (2019)

Article Chemistry, Multidisciplinary

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Rahul T. Kadakia et al.

CHEMICAL COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles

Lijiao Yang et al.

ACS NANO (2018)

Article Chemistry, Multidisciplinary

In vivo drug tracking with 19F MRI at therapeutic dose

Shaowei Bo et al.

CHEMICAL COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

F-19 PARASHIFT Probes for Magnetic Resonance Detection of H2O2 and Peroxidase Activity

Meng Yu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Chemistry, Multidisciplinary

Perfluorocarbon-Based 19F MRI Nanoprobes for In Vivo Multicolor Imaging

Kazuki Akazawa et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Chemistry, Multidisciplinary

Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles

Amani L. Lee et al.

ACS NANO (2017)

Article Chemistry, Physical

Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging

Alexander A. Kislukhin et al.

NATURE MATERIALS (2016)

Review Chemistry, Multidisciplinary

19F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

Ilaria Tirotta et al.

CHEMICAL REVIEWS (2015)

Article Chemistry, Multidisciplinary

Single 19F Probe for Simultaneous Detection of Multiple Metal Ions Using miCEST MRI

Amnon Bar-Shir et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Nanoscience & Nanotechnology

Bioreducible POSS-Cored Star-Shaped Polycation for Efficient Gene Delivery

Yan-Yu Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

Article Chemistry, Multidisciplinary

A Superfluorinated Molecular Probe for Highly Sensitive in Vivo19F-MRI

Ilaria Tirotta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Chemistry, Multidisciplinary

Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo

Barbara E. Rolfe et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Clinical Cell Therapy Imaging Using a Perfluorocarbon Tracer and Fluorine-19 MRI

Eric T. Ahrens et al.

MAGNETIC RESONANCE IN MEDICINE (2014)

Article Chemistry, Multidisciplinary

Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes

Xiaonan Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Radiology, Nuclear Medicine & Medical Imaging

Bimodal Perfluorocarbon Nanoemulsions for Nasopharyngeal Carcinoma Targeting

Pan Kee Bae et al.

MOLECULAR IMAGING AND BIOLOGY (2013)

Article Chemistry, Multidisciplinary

A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent

Zijian Zhou et al.

ADVANCED MATERIALS (2012)

Article Immunology

Trogocytosis of CD80 and CD86 by induced regulatory T cells

Peng Gu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2012)

Article Chemistry, Multidisciplinary

Design of Chemical Shift-Switching 19F Magnetic Resonance Imaging Probe for Specific Detection of Human Monoamine Oxidase A

Koya Yamaguchi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Chemistry, Multidisciplinary

Functional Hyperbranched Polymers: Toward Targeted in Vivo 19F Magnetic Resonance Imaging Using Designed Macromolecules

Kristofer J. Thurecht et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Review Chemistry, Multidisciplinary

Bioresponsive, Cell-Penetrating, and Multimeric MR Contrast Agents

Jody L. Major et al.

ACCOUNTS OF CHEMICAL RESEARCH (2009)

Article Chemistry, Multidisciplinary

Symmetry-Guided Design and Fluorous Synthesis of a Stable and Rapidly Excreted Imaging Tracer for F-19 MRI

Zhong-Xing Jiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Biochemistry & Molecular Biology

Reversible signal regulation system of F-19 NMR by redox reactions using a metal complex as a switching module

Kazuo Tanaka et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Multiplexed Imaging of Therapeutic Cells with Multispectrally Encoded Magnetofluorescent Nanocomposite Emulsions

Yong Taik Lim et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model

Mangala Srinivas et al.

MAGNETIC RESONANCE IN MEDICINE (2007)

Article Biochemistry & Molecular Biology

19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons

Kathryn C. Partlow et al.

FASEB JOURNAL (2007)

Article Biotechnology & Applied Microbiology

Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy

IJM de Vries et al.

NATURE BIOTECHNOLOGY (2005)

Article Biotechnology & Applied Microbiology

In vivo imaging platform for tracking immunotherapeutic cells

ET Ahrens et al.

NATURE BIOTECHNOLOGY (2005)