☆ 4.6 Article

Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module

ACS CHEMICAL BIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase

Franziska Hemmerling et al.

Summary: In this study, a remarkably versatile trans-acyltransferase (trans-AT) PKS from Serratia was characterized, which builds structurally complex macrolides via over ten functionally distinct PKS modules. A new oxygenation module and a halogenating module were identified, along with modular O-acetylation.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Poly(dehydroalanine): Synthesis, Properties, and Functional Diversification of a Fluorescent Polypeptide

Isaac Benavides et al.

Summary: A new soluble poly(S-alkyl-L-cysteine) precursor was designed for the successful preparation of long-chain poly(dehydroalanine) and the incorporation of dehydroalanine residues and A(DH) segments into copolypeptides. A(DH) was found to adopt a unique hybrid coil structure and possess inherent blue fluorescence suitable for imaging applications. Its reactive electrophilic groups allow for efficient modification under mild conditions, making it a unique component for self-assembled biomaterials.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Review Microbiology

Tackling the emerging threat of antifungal resistance to human health

Matthew C. Fisher et al.

Summary: This review emphasizes the important threat of invasive fungal infections to public health and the emergence of antifungal resistance. It discusses the main mechanisms of antifungal resistance and compares them with bacterial resistance to antimicrobial control. The review also explores the research and innovation topics needed to minimize the occurrence and impact of antifungal resistance, including environmental links, surveillance, diagnostics, transmission routes, novel therapeutics, and hotspot mitigation strategies. The need for global efforts to manage existing antifungal drugs and direct future research and development of therapies and interventions is highlighted.

NATURE REVIEWS MICROBIOLOGY (2022)

Add to Collection

Article Microbiology

Nonribosomal Peptide Synthesis Definitely Working Out of the Rules

Matthieu Duban et al.

Summary: Nonribosomal peptides are secondary metabolites produced by microorganisms, with diverse structures and broad biological activities. They are synthesized by multimodular enzymes called nonribosomal peptide synthetases, which assemble the peptide chain through a series of modules.

MICROORGANISMS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis

Amy E. Fraley et al.

Summary: This study provides the first structural insights into a distinct group of TEs (TE(B)s) that have diverse acylation roles in polyketide and peptide biosynthesis. By analyzing and engineering the active site, the acyl-group acceptance can be modulated. Moreover, the production of longer chain branched oocydins was discovered, positioning this enzyme as a valuable synthetic biology tool for polyketide drug development.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection

Article Microbiology

Solanimycin: Biosynthesis and Distribution of a New Antifungal Antibiotic Regulated by Two Quorum-Sensing Systems

Miguel A. Matilla et al.

Summary: The emergence of drug-resistant fungal infections has led to the search for new compounds to combat fungal pathogens. This study describes the discovery and characterization of a new antifungal compound, solanimycin, produced by a hybrid polyketide/nonribosomal peptide system. Solanimycin exhibited broad-spectrum antifungal activity against plant-pathogenic fungi and Candida albicans. The genomic cluster responsible for solanimycin production was identified and analyzed, and its production was enhanced under certain conditions. The study suggests potential utility of solanimycin for agricultural and clinical exploitation.

MBIO (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Discovery and Biosynthetic Investigation of a New Antibacterial Dehydrated Non-Ribosomal Tripeptide

Shan Wang et al.

Summary: This study discovered a new antimicrobial peptide, albopeptide, containing two contiguous unsaturated residues, Dha-(E)-Dhb, with narrow-spectrum activity against vancomycin-resistant Enterococcus faecium. The research also demonstrated that albopeptide is synthesized through a noncanonical NRPS pathway and revealed the presence of a previously untapped group of short unsaturated peptides in the bacterial kingdom, suggesting an important biological function in bacteria.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Review Microbiology

Recent Approaches towards Control of Fungal Diseases in Plants: An Updated Review

Nawal Abd El-Baky et al.

Summary: Recent research shows that the number of virulent phytopathogenic fungi is increasing globally, leading to economic losses. Traditional use of chemical and synthetic fungicides faces challenges due to resistance and negative impacts. Scientists are exploring new approaches and green strategies for fungal control, aiming to bring these technologies to farmers.

JOURNAL OF FUNGI (2021)

Add to Collection

Article Biochemistry & Molecular Biology

antiSMASH 6.0: improving cluster detection and comparison capabilities

Kai Blin et al.

Summary: antiSMASH, a tool for detecting biosynthetic gene clusters in microorganisms, has been updated to version 6, which increases the supported cluster types, displays the structure of multi-modular BGCs, adds a new comparison algorithm, allows integration of results from other prediction tools, and improves detection of tailoring enzymes in RiPP clusters.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Pass-back chain extension expands multimodular assembly line biosynthesis

Jia Jia Zhang et al.

NATURE CHEMICAL BIOLOGY (2020)

Add to Collection

Review Food Science & Technology

Threats to global food security from emerging fungal and oomycete crop pathogens

Helen N. Fones et al.

NATURE FOOD (2020)

Add to Collection

Review Microbiology

The Still Underestimated Problem of Fungal Diseases Worldwide

Fausto Almeida et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Mechanism of Integrated β-Lactam Formation by a Nonribosomal Peptide Synthetase during Antibiotic Synthesis

Darcie H. Long et al.

BIOCHEMISTRY (2018)

Add to Collection

Review Multidisciplinary Sciences

Worldwide emergence of resistance to antifungal drugs challenges human health and food security

Matthew C. Fisher et al.

SCIENCE (2018)

Add to Collection

Article Microbiology

Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

Xiuqing Yang et al.

MBIO (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359

Max Cruesemann et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin

Jon B. Patteson et al.

BIOCHEMISTRY (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

Michio Sato et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

The Ecological Role of Volatile and Soluble Secondary Metabolites Produced by Soil Bacteria

Olaf Tyc et al.

TRENDS IN MICROBIOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases

Dayu Yu et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Microbiology

Chemical ecology of antibiotic production by actinomycetes

Anne Van der Meij et al.

FEMS MICROBIOLOGY REVIEWS (2017)

Add to Collection

Review Chemistry, Multidisciplinary

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

Lindsay M. Repka et al.

CHEMICAL REVIEWS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria

Christian Burgard et al.

ACS CHEMICAL BIOLOGY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Biocatalytic Total Synthesis of Ikarugamycin

Christian Greunke et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Add to Collection

Review Chemistry, Multidisciplinary

Nonribosomal Peptide Synthesis-Principles and Prospects

Roderich D. Suessmuth et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Add to Collection

Review Biotechnology & Applied Microbiology

Iterative polyketide biosynthesis by modular polyketide synthases in bacteria

Haotong Chen et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Biosynthesis of polyketides by trans-AT polyketide synthases

Eric J. N. Helfrich et al.

NATURAL PRODUCT REPORTS (2016)

Add to Collection

Review Biochemistry & Molecular Biology

New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products

Manuel A. Ortega et al.

CELL CHEMICAL BIOLOGY (2016)

Add to Collection

Article Biotechnology & Applied Microbiology

Unusual Biosynthesis and Structure of Locillomycins from Bacillus subtilis 916

Chuping Luo et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

Add to Collection

Article Microbiology

Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq

Miguel A. Matilla et al.

ENVIRONMENTAL MICROBIOLOGY (2015)

Add to Collection

Article Multidisciplinary Sciences

β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

Nicole M. Gaudelli et al.

NATURE (2015)

Add to Collection

Article Chemistry, Medicinal

Two New Diketopiperazines from ARUM Palaestinum

Samy K. El-Desouky et al.

CHEMISTRY OF NATURAL COMPOUNDS (2014)

Add to Collection

Review Rheumatology

Gusperimus: immunological mechanism and clinical applications

Miklos Perenyei et al.

RHEUMATOLOGY (2014)

Add to Collection

Article Chemistry, Analytical

XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data

Ralf Tautenhahn et al.

ANALYTICAL CHEMISTRY (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Bacterial Biosynthetic Gene Clusters Encoding the Anti-cancer Haterumalide Class of Molecules BIOGENESIS OF THE BROAD SPECTRUM ANTIFUNGAL AND ANTI-OOMYCETE COMPOUND, OOCYDIN A

Miguel A. Matilla et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Add to Collection

Article Multidisciplinary Sciences

The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity

Nadine Ziemert et al.

PLOS ONE (2012)

Add to Collection

Review Biochemistry & Molecular Biology

Occurrence, Biosynthesis, Biodegradation, and Industrial and Medical Applications of a Naturally Occurring ε-Poly-L-lysine

Yoshimitsu Hamano

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2011)

Add to Collection

Article Chemistry, Multidisciplinary

Three New 3,6-Dioxygenated Diketopiperazines from the Basidiomycete Lepista sordida

Xiang-Lian Chen et al.

HELVETICA CHIMICA ACTA (2011)

Add to Collection

Article Chemistry, Multidisciplinary

Biosynthetic Gene Cluster of the Non-ribosomally Synthesized Cyclodepsipeptide Skyllamycin: Deciphering Unprecedented Ways of Unusual Hydroxylation Reactions

Stefan Pohle et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Add to Collection

Review Agronomy

Dickeya species: an emerging problem for potato production in Europe

I. K. Toth et al.

PLANT PATHOLOGY (2011)

Add to Collection

Article Chemistry, Multidisciplinary

Identification of a Nonaketide Product for the Iterative Polyketide Synthase in Biosynthesis of the Nine-Membered Enediyne C-1027

Xiaolei Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Add to Collection

Article Biotechnology & Applied Microbiology

Identification of a Novel Two-Peptide Lantibiotic, Lichenicidin, following Rational Genome Mining for LanM Proteins

Maire Begley et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)

Add to Collection

Article Plant Sciences

Myxochromide B-3, a New Member of the Myxochromide Family of Secondary Metabolites

Birgit Ohlendorf et al.

JOURNAL OF NATURAL PRODUCTS (2008)

Add to Collection

Review Multidisciplinary Sciences

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

Goro Kikuchi et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2008)

Add to Collection

Article Chemistry, Multidisciplinary

Nonribosomal peptide biosynthesis: Point mutations and module skipping lead to chemical diversity

SC Wenzel et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Add to Collection

Article Biochemical Research Methods

Structure investigation of Maltacine D1a, D1b and D1c -: cyclic peptide lactones of the Maltacine complex from Bacillus subtilis

G Hagelin

JOURNAL OF MASS SPECTROMETRY (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca:: Evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis

SC Wenzel et al.

CHEMBIOCHEM (2005)

Add to Collection

Article Plant Sciences

Novel polyene carboxylic acids from Streptomyces

SC Wenzel et al.

JOURNAL OF NATURAL PRODUCTS (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.