4.8 Article

Nanowhiskers Orchestrate Bone Formation and Bone Defect Repair by Modulating Immune Cell Behavior

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Titanium surface with nanospikes tunes macrophage polarization to produce inhibitory factors for osteoclastogenesis through nanotopographic cues

Nadia Kartikasari et al.

Summary: This study shows that titanium nanosurfaces with anisotropically patterned nanospikes can regulate macrophage polarization to inhibit osteoclast differentiation of osteoclast precursors, indicating that nanotopographic cues play a key role in this process rather than other physicochemical properties.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Multidisciplinary

A Novel Hollow-Tube-Biphasic-Whisker-Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

Cong Feng et al.

Summary: By fabricating hollow-tube-whisker-modified biphasic calcium phosphate (BCP-HW) ceramics through an in situ growth process, a good balance between mechanical strength and osteogenic activity is achieved, providing stronger stimulation on the adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Materials Science, Biomaterials

Improved BMP2-CPC-stimulated osteogenesis in vitro and in vivo via modulation of macrophage polarization

Hongzhou Shen et al.

Summary: This study revealed that BMP2-CPC possessed favorable immunoregulatory properties, enhancing its strong osteogenic capability by modulating macrophage polarization.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Materials Science, Biomaterials

Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Da-Wang Zhao et al.

Summary: Titanium and its alloys are promising scaffold materials for dental and orthopedic implants due to their ideal mechanical properties and biocompatibility, but host immune response often leads to implant failures. Surface modification, such as the CSZP coating, is crucial for regulating host immune response and promoting bone regeneration. IL-4 delivery can modulate immune response for bone regeneration on the CSZP coating effectively.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Immunology

Anethole inhibits RANKL-induced osteoclastogenesis by downregulating ERK/AKT signaling and prevents ovariectomy-induced bone loss in vivo

Hao Qu et al.

Summary: Postmenopausal osteoporosis is a chronic systemic metabolic disease caused by excessive bone resorption and reduced bone formation. Anethole, a natural compound, shows potential in inhibiting osteoclast differentiation, reducing bone resorption, and suppressing osteoclast-specific gene expression through blocking ERK and AKT signaling pathways. Our study suggests that anethole may have osteoprotective effects and be a potential treatment for osteoporosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Immunology

Irf1-and Egr1-activated transcription plays a key role in macrophage polarization: A multiomics sequencing study with partial validation

Yan-Biao Chu et al.

Summary: The study identified key transcription factors in macrophage polarization through ATAC-seq and RNA-seq, highlighting the crucial roles of Irf1 and Egr1 in regulating M1 and M2 macrophages, respectively.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Cardiac & Cardiovascular Systems

Early Growth Response-1, an Integrative Sensor in Cardiovascular and Inflammatory Disease

Levon M. Khachigian

Summary: Egr-1 serves as a master regulator and transcriptional sensor in vascular dysfunction and disease, amplifying pathologic signals by inducing the expression of proliferative, migratory, and proinflammatory genes. Targeting Egr-1 may offer therapeutic benefits in cardiovascular and inflammatory disorders.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Multidisciplinary Sciences

Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

Yizhou Zhu et al.

Summary: The study showed that reducing the scale of honeycomb-like TiO2 structures can activate anti-inflammatory macrophage phenotype, promoting osteogenesis. Among different scales, the 90-nanometer sample demonstrated the most effective outcomes in both in vitro cell culture and in vivo implantation experiments.

SCIENCE ADVANCES (2021)

Article Engineering, Biomedical

Serial cellular events in bone formation initiated by calcium phosphate ceramics

Xiaodong Guo et al.

Summary: The study revealed that osteoinductive calcium phosphate ceramic triggers key cellular events: macrophages colonize within hours to days, M2 macrophage polarization occurs within 7 days, osteoclastogenesis mainly occurs in weeks (e.g. in 2 weeks), and bone formation eventually arises thereafter (after 4 weeks). Such findings provide insights into material-induced bone formation and pave the way for further exploration of mechanisms triggered by osteoinductive materials.

ACTA BIOMATERIALIA (2021)

Review Materials Science, Biomaterials

Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration

Yajuan Xie et al.

REGENERATIVE BIOMATERIALS (2020)

Review Nanoscience & Nanotechnology

Materials design for bone-tissue engineering

Gerry L. Koons et al.

NATURE REVIEWS MATERIALS (2020)

Article Dentistry, Oral Surgery & Medicine

Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp

Jianfei Zhang et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2019)

Review Engineering, Biomedical

Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization

Sarah Adams et al.

ANNALS OF BIOMEDICAL ENGINEERING (2019)

Review Immunology

The Metabolic Signature of Macrophage Responses

Antonella Viola et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Generation and Characterization of Antibodies against Opioid Receptors from Zebrafish

Juan C. Arevalo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Cell & Tissue Engineering

Multinucleated Giant Cells: Good Guys or Bad Guys?

Richard J. Miron et al.

TISSUE ENGINEERING PART B-REVIEWS (2018)

Article Chemistry, Multidisciplinary

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

Pei Feng et al.

ADVANCED SCIENCE (2018)

Article Engineering, Biomedical

Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis

Houhua Pan et al.

BIOMEDICAL MATERIALS (2017)

Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

Article Materials Science, Multidisciplinary

Osteoimmunomodulation for the development of advanced bone biomaterials

Zetao Chen et al.

MATERIALS TODAY (2016)

Article Materials Science, Multidisciplinary

Biomaterial based modulation of macrophage polarization: a review and suggested design principles

Rukmani Sridharan et al.

MATERIALS TODAY (2015)

Review Biochemistry & Molecular Biology

Physical and mechanical regulation of macrophage phenotype and function

Frances Y. McWhorter et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

Article Engineering, Biomedical

Osteoclast resorption of beta-tricalcium phosphate controlled by surface architecture

Noel L. Davison et al.

BIOMATERIALS (2014)

Article Materials Science, Multidisciplinary

Fabrication and characterization of porous 3D whisker-covered calcium phosphate scaffolds

Xingjiang Ye et al.

MATERIALS LETTERS (2014)

Article Medicine, Research & Experimental

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

Sunao Takeshita et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Engineering, Biomedical

Macrophage polarization: An opportunity for improved outcomes in and regenerative medicine

Bryan N. Brown et al.

BIOMATERIALS (2012)

Article Medicine, Research & Experimental

Macrophage plasticity and polarization: in vivo veritas

Antonio Sica et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Rheumatology

Fracture healing under healthy and inflammatory conditions

Lutz Claes et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Article Multidisciplinary Sciences

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

Larry Pederson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Materials Science, Ceramics

Whisker-reinforced calcium phosphate cements

Frank A. Mueller et al.

JOURNAL OF THE AMERICAN CERAMIC SOCIETY (2007)

Article Engineering, Biomedical

In vivo mechanisms of hydroxyapatite ceramic degradation by osteoclasts: Fine structural microscopy

S Wenisch et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2003)

Article Engineering, Biomedical

The biodegradation mechanism of calcium phosphate biomaterials in bone

JX Lu et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2002)

Article Cell Biology

Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage

DS Miao et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2002)