4.8 Article

Bioinspired Piezoelectric Periosteum to Augment Bone Regeneration via Synergistic Immunomodulation and Osteogenesis

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis

Limei Li et al.

Summary: This study developed a novel immunomodulatory gastrodin-polyurethane/nano-hydroxyapatite composite material that promotes osteogenesis and angiogenesis. The results demonstrated that the composite material can induce macrophage polarization towards the anti-inflammatory M2 phenotype, and significantly enhance the expression of osteogenesis and angiogenesis-related factors in bone and endothelial cells.

BIOACTIVE MATERIALS (2023)

Article Engineering, Biomedical

Endothelialized microvessels fabricated by microfluidics facilitate osteogenic differentiation and promote bone repair

Jiayuan Wang et al.

Summary: Vascularization is a critical factor in bone tissue engineering, and lack of endothelialization remains a challenge. This study developed a technique to fabricate endothelialized biomimetic microvessels using microfluidic technology, which showed promising results in promoting osteogenesis and bone regeneration both in vitro and in vivo. These findings suggest that endothelialized BMVs could be an effective strategy in bone tissue engineering.

ACTA BIOMATERIALIA (2022)

Article Engineering, Biomedical

An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties

Weizhen Chen et al.

Summary: This study focuses on the surface modification of metal implants using pitavastatin to enhance bone defect healing through the synergistic osteogenesis-angiogenesis regulation. The researchers constructed multilayer films with osteogenic and angiogenic properties on pure titanium substrates, and found that locally applied pitavastatin dramatically enhanced the osteogenic potential of mesenchymal stem cells (MSCs) and the angiogenic potential of endothelial cells (ECs). Furthermore, the pitavastatin-loaded films were able to regulate the paracrine signaling between MSCs and ECs, indirectly increasing the angiogenic potential of MSCs and the osteogenic potential of ECs. Subcutaneous and femur implantation experiments confirmed that locally released pitavastatin promoted endogenous stem cells and ECs to the implant-bone interface, facilitating coupled osteogenesis and angiogenesis, and enhancing peri-implant osseointegration.

BIOMATERIALS (2022)

Article Engineering, Biomedical

CD271 antibody-functionalized microspheres capable of selective recruitment of reparative endogenous stem cells for in situ bone regeneration

Han Sun et al.

Summary: In this study, CD271 antibody-functionalized chitosan microspheres were successfully developed to recruit bone marrow mesenchymal stem cells (BM-MSCs) for in situ bone regeneration. The polydopamine (PDA) coating played a critical role in supporting the adhesion and proliferation of BM-MSCs. Effective recruitment of CD271(+) stem cells by the functionalized microspheres at the bone defect site in rats led to significantly enhanced new bone formation over the long term.

BIOMATERIALS (2022)

Article Nanoscience & Nanotechnology

Spatiotemporal Management of the Osteoimmunomodulation of Fibrous Scaffolds by Loading a Novel Amphiphilic Nanomedicine

Min He et al.

Summary: This study proposes an amphiphilic nanomedicine with dual anti-inflammatory functions and inflammation-responsive drug release properties to spatiotemporally manage the osteoimmunomodulation of the bone scaffold, potentially improving in vivo osteogenesis.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Multidisciplinary

Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

Yuna Qian et al.

Summary: A novel glycyrrhizic acid-based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing.

ADVANCED MATERIALS (2022)

Article Engineering, Biomedical

Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation

Yaping Wang et al.

Summary: A synthetic fibrous glycopeptide hydrogel was developed and composited with 3D-printed PCL/nHA scaffold for cranial bone regeneration, showing significant promotion of stem cell proliferation and osteogenic differentiation as well as enhanced interaction between macrophages and stem cells. The composite scaffold exhibited superior efficacy in bone regeneration and osseointegration, creating a reparative microenvironment similar to normal cranium with increased anti-inflammatory macrophages and osteoblasts.

BIOMATERIALS (2022)

Article Materials Science, Multidisciplinary

Hierarchically multifunctional bioactive nanoglass for integrated tumor/infection therapy and impaired wound repair

Mi Chen et al.

Summary: This study develops a multifunctional bioactive material BSr@PPE, which exhibits photothermal effect, antibacterial activity, and biocompatibility, to promote wound repair under tumor and infection-impaired conditions.

MATERIALS TODAY (2022)

Article Chemistry, Multidisciplinary

Reinforced Blood-Derived Protein Hydrogels Enable Dual-Level Regulation of Bio-Physiochemical Microenvironments for Personalized Bone Regeneration with Remarkable Enhanced Efficacy

Sicong Ren et al.

Summary: Physiological microenvironment engineering has great potential in combating diseases. This study presents a rational design of reinforced and injectable blood-derived protein hydrogels, which can act as dual-level regulators to engineer the microenvironment for personalized bone regeneration with high efficacy.

NANO LETTERS (2022)

Article Multidisciplinary Sciences

An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis

Gonggong Lu et al.

Summary: In this study, an instantly fixable and self-adaptive scaffold was engineered to promote cranial reconstruction by calcium chelation and interface integration, while also regulating macrophage M2 polarization and recruiting endogenous stem cells.

NATURE COMMUNICATIONS (2022)

Article Chemistry, Multidisciplinary

Polydopamine Decorated Microneedles with Fe-MSC-Derived Nanovesicles Encapsulation for Wound Healing

Wenjuan Ma et al.

Summary: This study presents a novel wound dressing that combines antioxidation, antiinflammation, and efficient angiogenesis induction capacities, and demonstrates its excellent effect on diabetic wound healing in vivo.

ADVANCED SCIENCE (2022)

Review Orthopedics

Periosteum and development of the tissue-engineered periosteum for guided bone regeneration

Wentao Zhang et al.

Summary: The periosteum plays a significant role in bone formation and regeneration by storing progenitor cells and acting as a source of growth factors. Tissue-engineered periosteum, produced using biomimetic methods, can significantly improve the efficacy of bone grafting and scaffold engineering. The development of bionic periosteum in tissue engineering aims to accelerate bone defect repair.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2022)

Article Engineering, Biomedical

Enhanced tissue regeneration through immunomodulation of angiogenesis and osteogenesis with a multifaceted nanohybrid modified bioactive scaffold

Hang Xue et al.

Summary: In this study, multifaceted nanohybrids 5QCS-1GO-PDA were synthesized and showed excellent biocompatibility and enhanced healing ability. These nanohybrids can promote angiogenesis, bone regeneration, and macrophage polarization through multiple signaling pathways, providing a promising method for effectively treating tissue defects.

BIOACTIVE MATERIALS (2022)

Article Cell & Tissue Engineering

Mussel-inspired multifunctional surface through promoting osteogenesis and inhibiting osteoclastogenesis to facilitate bone regeneration

Minhao Wu et al.

Summary: The study successfully developed LYN/HA-coated hybrid scaffolds with dual therapeutic actions, promoting osteogenesis and inhibiting osteoclastogenesis, and confirmed their excellent performance and effects through experimental validations.

NPJ REGENERATIVE MEDICINE (2022)

Article Nanoscience & Nanotechnology

Self-Adhesive Hydrogel Biomimetic Periosteum to Promote Critical-Size Bone Defect Repair via Synergistic Osteogenesis and Angiogenesis

Zhen Yang et al.

Summary: This study proposes a biomimetic periosteum preparation strategy to enhance natural polymer hydrogel membranes using inorganic bioactive materials, improving the repair of critical-size bone defects. The addition of micro/nanobioactive glass into the hydrogel enhances stability, sustains degradation time, promotes cell recruitment and vascularization, and stimulates bone defect repair.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Multidisciplinary

Osteoimmunity-Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration

Jin Zhang et al.

Summary: Engineering a biomimetically hierarchical scaffold can improve bone tissue regeneration by facilitating the balance of the immune system and bone metabolism. The scaffold exhibits strong immunomodulatory, intensive angiogenic, weak osteoclastogenic, and superior osteogenic abilities, providing a valuable foundation and inspiration for large-scale bone defect repair.

ADVANCED MATERIALS (2022)

Review Engineering, Biomedical

Immunomodulatory strategies for bone regeneration: A review from the perspective of disease types

Ni Su et al.

Summary: This review discusses the progress in immunomodulation research for bone applications using biomaterials and cell-based strategies, with a focus on different disease types. The role of the immune system in orthopedic applications, including prolonging orthopaedic implant lifetime and enhancing fracture healing, is reviewed. Recent research progress in harnessing immunomodulatory strategies for regenerating critical-sized, long bone or cranial bone defects, and treating osteolytic bone diseases is also discussed.

BIOMATERIALS (2022)

Article Engineering, Biomedical

ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation

Xuan Li et al.

Summary: In this study, a novel functionalized titanium implant with a hydrogel coating loaded with Tβ4 was designed and evaluated. The coating exhibited strong adhesion to the titanium substrate, and it could release Tβ4 in response to the immune reaction of bone healing, promoting vascularization and osteointegration of bone defects.

BIOMATERIALS (2022)

Article Engineering, Multidisciplinary

A hierarchical biomimetic periosteum combined immunomodulatory and osteogenic functions for bone regeneration

Xiaoming Li et al.

Summary: The biomimetic periosteum mimicking the fibrous and cambium layers of the natural periosteum has been found to have immunomodulatory and osteogenic functions. It has shown promising results in in vitro and in vivo experiments, making it a potential alternative to periosteal autografts.

COMPOSITES PART B-ENGINEERING (2022)

Article Engineering, Multidisciplinary

Accelerated bone defect regeneration through sequential activation of the M1 and M2 phenotypes of macrophages by a composite BMP-2@SIS An

Jie Tan et al.

Summary: The host's immune response plays a crucial role in the repair outcome of bone defects. Biomaterials with immunomodulatory properties and suitable degradation can promote bone defect regeneration and integration with the host. SIS hydrogel has been shown to induce macrophage polarization and enhance migration and tube formation of angiogenesis-associated cells.

COMPOSITES PART B-ENGINEERING (2022)

Article Engineering, Biomedical

Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes

Yazhen Li et al.

Summary: In this study, a polydopamine-mediated graphene oxide and hydroxyapatite nanoparticle-incorporated conductive scaffold was developed to accelerate periodontal bone regeneration in diabetic patients. The scaffold demonstrated conductivity, ROS-scavenging, anti-inflammatory, and immunomodulatory abilities, leading to excellent bone regeneration by modulating macrophage functions.

BIOACTIVE MATERIALS (2022)

Article Engineering, Biomedical

Bioinspired sandwich-like hybrid surface functionalized scaffold capable of regulating osteogenesis, angiogenesis, and osteoclastogenesis for robust bone regeneration

Minhao Wu et al.

Summary: This study demonstrates the potential of biofunctionalized implants to accelerate bone defect healing by loading a Wnt signaling activator onto a porous bone scaffold surface, combining angiogenesis and suppressing osteoclastogenesis.

MATERIALS TODAY BIO (2022)

Article Chemistry, Multidisciplinary

Remotely Temporal Scheduled Macrophage Phenotypic Transition Enables Optimized Immunomodulatory Bone Regeneration

Donghua Huang et al.

Summary: Precise timing of macrophage polarization plays a vital role in immunomodulation of tissue regeneration. In this study, a superparamagnetic hydrogel was developed to control the polarization of macrophages, enabling precise manipulation of inflammation progression and promoting tissue healing.

SMALL (2022)

Article Chemistry, Multidisciplinary

Regulation of Macrophage Polarization Through Periodic Photo-Thermal Treatment to Facilitate Osteogenesis

Bo Li et al.

Summary: In this study, anti-oxidized polydopamine (PDA) was deposited on hydroxyapatite nanorods to form a core-shell structural nanorod-like array (PDA@HA), which showed both ROS scavenging ability and near-infrared light derived photo-thermal effects. PDA@HA suppressed inflammation and the periodic photo-thermal treatment further accelerated the transition of macrophages from a pro-inflammatory phenotype to an anti-inflammatory phenotype, promoting osteogenesis through immunomodulatory mechanisms.

SMALL (2022)

Article Cell & Tissue Engineering

Shape Memory and Osteogenesis Capabilities of the Electrospun Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Modified Poly(l-Lactide) Fibrous Mats

Xianliu Wang et al.

Summary: This study demonstrates the enhanced shape memory and osteogenesis capabilities of electrospun PLLA-PHBV composite fibers. Incorporation of 30% PHBV into PLLA fibers significantly improves shape memory capability and decreases transition temperature. The fibrous PLLA-PHBV scaffold promotes osteogenic commitment in bone mesenchymal stem cells and could be used for bone regeneration with shape memory effect.

TISSUE ENGINEERING PART A (2021)

Article Chemistry, Multidisciplinary

A Hierarchical Janus Nanofibrous Membrane Combining Direct Osteogenesis and Osteoimmunomodulatory Functions for Advanced Bone Regeneration

Qian Wang et al.

Summary: This study developed a Janus guided bone regeneration membrane (JGM) with an inner layer promoting osteogenesis and an outer layer resisting bacterial infection, while also modulating macrophages polarization towards a favorable osteoimmune environment. The JGM demonstrated better in vivo bone tissue regeneration performance than a commercial Bio-Gide membrane, showcasing great potential for tissue engineering applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Engineering, Biomedical

Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration

Gaojie Yang et al.

Summary: The functional biomimetic membrane with micropatterns of site-specific biomineralization mimics the role of natural periosteum in bone regeneration. It can sustainably release calcium phosphate and growth factors, enhancing cell recruitment and differentiation, leading to improved vascularized ossification and accelerated new bone formation in a rat model.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Bioinspired Highly Anisotropic, Ultrastrong and Stiff, and Osteoconductive Mineralized Wood Hydrogel Composites for Bone Repair

Xiaofei Wang et al.

Summary: This study successfully fabricates highly anisotropic, ultrastrong and stiff, and osteoconductive hydrogel composites that possess excellent mechanical properties and biocompatibility for bone repair, through a biomimetic strategy inspired by natural bone and wood.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Biotechnology & Applied Microbiology

Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

Joanna E. Karbowniczek et al.

Summary: The study successfully produced PHBV scaffolds enriched with hydroxyapatite particles, which showed enhanced cell proliferation and filopodia formation, indicating great potential for bone tissue regeneration.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Engineering, Biomedical

Bioinspired Redwood-Like Scaffolds Coordinated by In Situ-Generated Silica-Containing Hybrid Nanocoatings Promote Angiogenesis and Osteogenesis both In Vitro and In Vivo

Minhao Wu et al.

Summary: This research introduces a novel biomimetic redwood-like material with multifunctional properties that promote bone defect repair. By precipitating SCPNs in a redwood-like scaffold, the engineered nanocomposite exhibits enhanced bioactivity.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Large fuzzy biodegradable polyester microspheres with dopamine deposition enhance cell adhesion and bone regeneration in vivo

Deteng Zhang et al.

Summary: Biodegradable polymer microparticles with hierarchical textures were fabricated in this study, with the surface microstructures stabilized against annealing and enhanced cell-material interaction through dopamine deposition. These microspheres significantly promoted bone regeneration in vivo, as confirmed by various analyses.

BIOMATERIALS (2021)

Review Biochemistry & Molecular Biology

Piezoelectric Signals in Vascularized Bone Regeneration

Delfo D'Alessandro et al.

Summary: The demand for bone substitutes is rising in Western countries, with new strategies needed to promote bone and blood vessel generation within scaffolds. Piezoelectricity has been shown to be a stimulating signal for bone and vascular tissue regeneration, offering potential in developing successful vascularized bone replacements.

BIOMOLECULES (2021)

Article Cell & Tissue Engineering

Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants

Barbara M. de Sousa et al.

Summary: Novel bioelectronic devices consisting of biophysical stimulators and sensing systems aim to provide long-term control of peri-implant bone growth by monitoring the biointerface. High frequency (HF) stimulation can significantly impact osteoblasts' synthesis, matrix, and mineral deposition, as well as enhance osteogenic commitment and hydroxyapatite deposition in mesenchymal stem cells. These bioelectric implants show promise in providing personalized stimulation to peri-implant tissues for improved osseointegration and long-term success of orthopedic surgeries.

NPJ REGENERATIVE MEDICINE (2021)

Article Multidisciplinary Sciences

Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

Yizhou Zhu et al.

Summary: The study showed that reducing the scale of honeycomb-like TiO2 structures can activate anti-inflammatory macrophage phenotype, promoting osteogenesis. Among different scales, the 90-nanometer sample demonstrated the most effective outcomes in both in vitro cell culture and in vivo implantation experiments.

SCIENCE ADVANCES (2021)

Article Engineering, Biomedical

A low-temperature-printed hierarchical porous sponge-like scaffold that promotes cell-material interaction and modulates paracrine activity of MSCs for vascularized bone regeneration

Meifei Lian et al.

Summary: The sponge-like scaffolds developed using low temperature deposition modeling (LDM) printing showed significant promotion in cellular behavior and paracrine secretion patterns of MSCs, enhancing multiple regenerative processes such as immunomodulation, angiogenesis, and osteogenesis. This suggests potential applications in tissue engineering and tissue regeneration enhancement through optimization of biomaterial properties to direct the paracrine signaling of MSCs.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Mussel patterned with 4D biodegrading elastomer durably recruits regenerative macrophages to promote regeneration of craniofacial bone

Xuzheng Liu et al.

Summary: The study showed that by rational designing hierarchically porous membranes with 3D microstructure, it can facilitate early and durable influx of M2 macrophages, promoting recruitment of BMSCs and osteogenesis. Additionally, the 4D morphing of the membrane can fully regenerate calvarial bone and arcshape bone.

BIOMATERIALS (2021)

Article Biotechnology & Applied Microbiology

An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration

Tian Ding et al.

Summary: The study developed a core/shell fibrous scaffold with immunomodulatory and angiogenic properties for effective periodontal bone defect repair. This scaffold demonstrated promising results in promoting periodontal bone regeneration by modulating osteoimmune environment and enhancing angiogenesis.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Multidisciplinary Sciences

Biomaterials with structural hierarchy and controlled 3D nanotopography guide endogenous bone regeneration

Shixuan Chen et al.

Summary: This study describes a class of 3D nanofiber scaffolds with hierarchical structure and controlled alignment for effective endogenous cranial bone regeneration. The radially aligned nanofibers in the scaffolds promoted the migration of bone marrow stem cells, resulting in the highest new bone volume, surface coverage, and mineral density among the tested groups in vivo. The regenerated bone exhibited a radially aligned fashion and showed a densely packed structure in the organic phase and a uniform distribution with smaller pore size in the inorganic mineral phase.

SCIENCE ADVANCES (2021)

Review Chemistry, Multidisciplinary

Piezoelectric Nano-Biomaterials for Biomedicine and Tissue Regeneration

Kausik Kapat et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Bioactive Pore-Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing

Liju Xu et al.

ADVANCED MATERIALS (2020)

Article Nanoscience & Nanotechnology

Nanoscaled Bionic Periosteum Orchestrating the Osteogenic Microenvironment for Sequential Bone Regeneration

Hanwen Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Biochemistry & Molecular Biology

Biomimetic mineralization of novel hydroxyethyl cellulose/soy protein isolate scaffolds promote bone regeneration in vitro and in vivo

Minhao Wu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Materials Science, Biomaterials

Diatom shell incorporated PHBV/PCL-pullulan co-electrospun scaffold for bone tissue engineering

Ali Deniz Dalgic et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Chemistry, Multidisciplinary

Biomimetic Nanosilica-Collagen Scaffolds for In Situ Bone Regeneration: Toward a Cell-Free, One-Step Surgery

Shao-Jie Wang et al.

ADVANCED MATERIALS (2019)

Review Engineering, Biomedical

Hierarchically designed bone scaffolds: From internal cues to external stimuli

Yingying Du et al.

BIOMATERIALS (2019)

Review Engineering, Biomedical

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

Biranche Tandon et al.

ACTA BIOMATERIALIA (2018)

Article Materials Science, Multidisciplinary

In vivo demonstration of the suitability of piezoelectric stimuli for bone reparation

C. Ribeiro et al.

MATERIALS LETTERS (2017)

Review Materials Science, Biomaterials

Periosteum tissue engineering-a review

Nanying Li et al.

BIOMATERIALS SCIENCE (2016)

Review Engineering, Biomedical

Piezoelectric materials for tissue regeneration: A review

Amir Hossein Rajabi et al.

ACTA BIOMATERIALIA (2015)

Review Rheumatology

Fracture healing: mechanisms and interventions

Thomas A. Einhorn et al.

NATURE REVIEWS RHEUMATOLOGY (2015)

Article Engineering, Biomedical

Poly(vinylidene-trifluoroethylene)/barium titanate composite for in vivo support of bone formation

Helena B. Lopes et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2014)