Journal
ADVANCED NANOBIOMED RESEARCH
Volume 2, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anbr.202200081
Keywords
bioelectronics; electrophysiological recordings; multielectrode arrays; organoids; soft electronics
Funding
- Ministry of Science ICT (MSIT)
- Ministry of Trade, Industry and Energy (MOTIE)
- Ministry of Health Welfare
- Ministry of Food and Drug Safety of Korea through the National Research Foundation for Nano Material Technology Development Program [2018M3A9F1021649]
- Bio & Medical Technology Development Program [2020M3H1A1077207]
- Korea Initiative for fostering University of Research and Innovation (KIURI) Program [20013621]
- Technology Innovation Program (Center for Super Critical Material Industrial Technology) [RMS 2022-11-1209/KMDF RS-2022-00141392]
- Korea Medical Device Development Fund [SRFC-TC2003-03]
- Samsung Research Funding & Incubation Center of Samsung Electronics [IBS-R026-D1]
- Institute for Basic Science
- [2021M3D1A2049914]
- Korea Evaluation Institute of Industrial Technology (KEIT) [20013621] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2018M3A9F1021649] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This paper reviews the latest advances in recording platforms and provides a comprehensive study of electrophysiological factors. It discusses the current challenges and prospects for next-generation electrophysiological analysis of brain and heart organoids.
Organoids refer to 3D stem cells that have been developed to model neurological disorders in vitro. Typically, brain and heart organoids have gained interest for their potential to truly mimic the functional ability of real organs. Morphological analysis methods using immunostaining and slicing of the organoids are explored extensively over the past decade to evaluate the structures and functions of organoids. However, the destructiveness of these methods limits real-time monitoring of the dynamic responses of the organoids. Therefore, electrophysiological functional analysis of organoids with minimally invasive forms can be a key solution to an improved understanding of the nature of complex organoids. Herein, the latest advances in the recording platforms are reviewed and a comprehensive study of considerations regarding electrophysiological factors is provided. Furthermore, current challenges are discussed along with prospects for next-generation electrophysiological analysis of brain and heart organoids.
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