Journal
ADVANCED NANOBIOMED RESEARCH
Volume 3, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anbr.202200103
Keywords
blood substitutes; hemoglobin-related biomaterials; inflammatory diseases; tumor therapy; wound healing
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This article summarizes the applications of hemoglobin and its related biomaterials in medical treatment, including the clinical progress of Hemoglobin-based oxygen carriers as blood substitutes, and their applications in tumor therapy, wound healing, and anti-inflammatory therapy. With the rapid development of science and technology, more versatile hemoglobin-related biomaterials will be designed for other applications in the future.
Hemoglobin (Hb) is a physiological oxygen-transport metalloprotein present in the red blood cells. With the in-depth study, many functions of Hb are developed, and kinds of Hb-related biomaterials are applied for biomedical therapeutics in the past decades. Herein, the recent advances of Hb-related biomaterials and their applications, including the clinical progress of Hb-based oxygen carriers (HBOCs) as blood substitutes, and the applications in the field of tumor therapy, wound healing, and anti-inflammation therapy through utilizing its function of multiple gas delivery (O-2, CO, NO), peroxidase-like catalysis, and targeting macrophage, are summarized. With the rapid development of science and technology, more versatile Hb-related biomaterials are designed in the future for other applications.
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