Journal
ADVANCED MATERIALS
Volume 27, Issue 33, Pages 4910-4917Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502486
Keywords
biodegradation; nanovesicles; photoacoustic imaging; photothermal effects; ultrasmall gold nanorods
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Funding
- China-Japan Union Hospital of Jilin University
- National Institute of Biomedical Imaging and Bioengineering (NIBIB)
- National Institutes of Health (NIH)
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A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (approximate to 60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: approximate to 8 nm x 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.
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