Is psilocybin an effective antidepressant and what is its Mechanism of action?

Goodwin et al.(1) report a single 25 mg dose of psilocybin has an antidepressant effect short-term in medication-resistant depression. Unanswered questions include drug blood level as a guide to dose, psychedelic effects relationship to antidepressant benefit, and potential suicide risk of psilocybin.

Automated summary

Goodwin et al. found that a single 25 mg dose of psilocybin has short-term antidepressant effects in medication-resistant depression. Unanswered questions include the relationship between psychedelic effects and antidepressant benefits, the use of drug blood levels as a guide to dosage, and the potential risk of suicide associated with psilocybin.