4.6 Review

N6-Detection, regulation, and functions of RNA methyladenosine modification in plants

Related references

Note: Only part of the references are listed.
Article Engineering, Environmental

Transcriptome-wide m6A methylation profile reveals regulatory networks in roots of barley under cadmium stress

Tingting Su et al.

Summary: The study revealed the transcriptional regulatory network of Cd stress response in barley roots, highlighting the crucial role of m6A methylation in the process and indicating a positive correlation between m6A methylation and gene expression.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Biochemistry & Molecular Biology

MODOMICS: a database of RNA modification pathways. 2021 update

Pietro Boccaletto et al.

Summary: MODOMICS database, established since 2006, has evolved from containing basic chemical structures of modified ribonucleosides to a comprehensive resource with new functionalities such as a catalog of RNA modifications linked to human diseases. The database, which is extensively linked to RCSB Protein Data Bank, provides users with an enhanced tool for research on RNA modification.

NUCLEIC ACIDS RESEARCH (2022)

Article Biotechnology & Applied Microbiology

The m(6)A reader MhYTP2 regulates MdMLO19 mRNA stability and antioxidant genes translation efficiency conferring powdery mildew resistance in apple

Tianli Guo et al.

Summary: The Malus YTH-domain family protein MhYTP2 was identified as an m(6)A reader in apple, and its overexpression could increase the mRNA m(6)A modification level and translation efficiency, enhancing resistance to apple powdery mildew. The study sheds light on the apple m(6)A profile, the effect of MhYTP2 on m(6)A profile, and the roles of m(6)A in mRNA stability and translation efficiency of specific genes.

PLANT BIOTECHNOLOGY JOURNAL (2022)

Article Chemistry, Multidisciplinary

FIONA1-Mediated m6A Modification Regulates the Floral Transition in Arabidopsis

Tao Xu et al.

Summary: The study discovers that FIO1 acts as a previously unknown m(6)A methyltransferase that mainly modifies the coding regions of Arabidopsis transcripts. FIO1-mediated m(6)A methylation determines the mRNA abundance of key regulatory genes, thereby regulating flowering time in plants.

ADVANCED SCIENCE (2022)

Article Biotechnology & Applied Microbiology

m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome

Lulu Hu et al.

Summary: In this study, the researchers introduced a new method called m(6)A-SAC-seq, which allows for quantitative analysis of m(6)A modification in the entire transcriptome. They found numerous dynamically changing m(6)A sites during cell differentiation, highlighting the importance of studying the dynamics and functional roles of m(6)A in various biological processes.

NATURE BIOTECHNOLOGY (2022)

Article Plant Sciences

MdMTA-mediated m(6)A modification enhances drought tolerance by promoting mRNA stability and translation efficiency of genes involved in lignin deposition and oxidative stress

Nan Hou et al.

Summary: This study reveals the global involvement and molecular regulatory mechanism of N-6-methyladenosine modification (m(6)A) in the drought response of perennial apple trees, providing candidate genes for the breeding of stress-tolerant apple cultivars.

NEW PHYTOLOGIST (2022)

Article Plant Sciences

MTA1-mediated RNA m6A modification regulates autophagy and is required for infection of the rice blast fungus

Zhiyong Ren et al.

Summary: This study reveals the functional importance of m(6)A methylation in infection of Magnaporthe oryzae, showing that it plays a critical role in autophagy and fungal virulence. The mutant with disrupted m(6)A modification showed reduced virulence due to blockage of appressorial penetration and invasive growth, accompanied by severe disordered autophagy process.

NEW PHYTOLOGIST (2022)

Article Multidisciplinary Sciences

FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development

Jiangbo Wei et al.

Summary: This study reveals that FTO mediates m(6)A demethylation of LINE1 RNA in mouse embryonic stem cells, regulating LINE1 RNA abundance and the local chromatin state. It also plays regulatory roles in shaping chromatin state and gene expression during mouse oocyte and embryonic development.

SCIENCE (2022)

Article Multidisciplinary Sciences

Two zinc finger proteins with functions in m6A writing interact with HAKAI

Mi Zhang et al.

Summary: Using in vivo interaction proteomics, the authors identified HIZ1 and HIZ2 as components of the Arabidopsis m(6)A writer complex. The loss of HIZ2 resulted in an 85% reduction in m(6)A abundance and severe developmental defects.

NATURE COMMUNICATIONS (2022)

Article Genetics & Heredity

Characteristics of N6-methyladenosine modification during sexual reproduction of Chlamydomonas reinhardtii

Ying Lv et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2022)

Article Plant Sciences

Drought induces epitranscriptome and proteome changes in stem-differentiating xylem of Populus trichocarpa

Yubang Gao et al.

Summary: In this study, the epitranscriptomic and proteomic regulation induced by drought treatment in poplar SDX was examined using Nanopore direct RNA sequencing and tandem mass tag-based proteomic analysis. The results showed that drought stress increased RNA degradation, reduced transcription and translation, and had an impact on the interplay among m(6)A, polyadenylation, PAL, and translation in the SDX of P. trichocarpa.

PLANT PHYSIOLOGY (2022)

Article Biochemistry & Molecular Biology

The RNA N6-methyladenosine demethylase ALKBH9B modulates ABA responses in Arabidopsis

Jun Tang et al.

Summary: The mRNA modification N-6-methyladenosine (m(6)A) plays vital roles in ABA responses, and ALKBH9B-mediated m(6)A demethylation is crucial for post-transcriptional regulation of ABA responses.

JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2022)

Article Plant Sciences

ALKBH9C, a potential RNA m6A demethylase, regulates the response of Arabidopsis to abiotic stresses and abscisic acid

Umme Amara et al.

Summary: This study investigates the function of ALKBH9C protein in seed germination and seedling growth in Arabidopsis thaliana under abiotic stress and ABA conditions. The results suggest that ALKBH9C acts as an m(6)A eraser and plays a crucial role in seed germination and seedling growth under abiotic stresses or ABA by affecting the stability of stress-responsive transcripts.

PLANT CELL AND ENVIRONMENT (2022)

Article Genetics & Heredity

FIONA1-mediated methylation of the 3'UTR of FLC affects FLC transcript levels and flowering in Arabidopsis

Bin Sun et al.

Summary: This study discovered the inhibitory role of FIONA1 methyltransferase in the flowering process of plants. Various differentially expressed genes and methylated RNAs, including RNA molecules that regulate flowering, were identified. Through the analysis of transcripts and methylated RNAs, the researchers found the mechanism of FIO1 methyltransferase in methylation of the FLOWERING LOCUS C transcript, further revealing the molecular mechanisms of flowering regulation.

PLOS GENETICS (2022)

Article Genetics & Heredity

FIONA1-mediated methylation of the 3′UTR of FLC affects FLC transcript levels and flowering in Arabidopsis

Bin Sun et al.

Summary: RNA adenosine bases can be transiently modified by adding a methyl-group to form N-6-methyladenosine (m(6)A). The FIO1 enzyme is responsible for the 3'-end methylation of FLOWERING LOCUS C (FLC) transcript, which stabilizes FLC mRNAs. This study provides new insights into the RNA modification process and its impact on gene expression.

PLOS GENETICS (2022)

Article Biotechnology & Applied Microbiology

FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorphogenesis and flowering

Chunling Wang et al.

Summary: The study revealed that FIONA1 is a crucial U6 m(6)A methyltransferase in Arabidopsis, which can regulate plant photomorphogenesis and flowering processes.

GENOME BIOLOGY (2022)

Article Plant Sciences

Transcriptome-wide analysis of epitranscriptome and translational efficiency associated with heterosis in maize

Jin-Hong Luo et al.

Summary: This study investigates the molecular mechanisms underlying heterosis in maize, revealing that transcriptional and post-transcriptional regulation make distinct contributions to hybrid vigor. Most genes with m(6)A modification in the hybrid display a non-additive expression pattern.

JOURNAL OF EXPERIMENTAL BOTANY (2021)

Article Multidisciplinary Sciences

METTL3 regulates heterochromatin in mouse embryonic stem cells

Wenqi Xu et al.

Summary: METTL3 regulates mouse embryonic stem-cell heterochromatin, critical for silencing retroviral elements and mammalian development. Through m(6)A methylation, METTL3 modulates integrity of IAP heterochromatin.

NATURE (2021)

Article Multidisciplinary Sciences

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

Jiadong Liu et al.

Summary: The study reveals that the m(6)A RNA modification and YTHDC1 play essential roles in regulating retrotransposons and cellular reprogramming during early mouse embryonic development.

NATURE (2021)

Article Biochemistry & Molecular Biology

Unique features of the m6A methylome and its response to drought stress in sea buckthorn (Hippophae rhamnoides Linn.)

Guoyun Zhang et al.

Summary: Recent studies have shown that m(6)A methylation of mRNA in plants plays a crucial role in regulating gene expression, particularly in metabolic biosynthesis. The m(6)A modification is highly conserved in plants and has a positive correlation with mRNA abundance, as well as a specific association with ABA biosynthesis.

RNA BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Analysis of N6-methyladenosine reveals a new important mechanism regulating the salt tolerance of sweet sorghum

Hongxiang Zheng et al.

Summary: The m6A modification in sweet sorghum plays a role in salt tolerance and stability of salt-resistant related transcripts under salt stress. Investigating the quantity and extent of m6A modifications on salt-resistance gene transcripts is crucial for assessing and determining the salt tolerance of crops.

PLANT SCIENCE (2021)

Article Multidisciplinary Sciences

RNA modifications detection by comparative Nanopore direct RNA sequencing

Adrien Leger et al.

Summary: Nanocompore is a new methodology for modification detection from Nanopore data, utilizing comparison between RNA samples of interest and non-modified control samples to identify modifications with positional accuracy in vitro and applicable to human and yeast RNA research.

NATURE COMMUNICATIONS (2021)

Article Biology

The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

Laura Arribas-Hernandez et al.

Summary: A study using HyperTRIBE technology reveals that most targets of plant YTH domain proteins ECT2 and ECT3 overlap, and they mainly redundantly regulate target mRNA, including its abundance, in the cytoplasm.

ELIFE (2021)

Article Biochemistry & Molecular Biology

Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies

Peizhe Song et al.

Summary: This study reveals that CPSF30-L acts as an m(6)A reader in plants, with its m(6)A-binding function playing a crucial role in the floral transition and ABA response; The m(6)A-binding activity of CPSF30-L enhances the formation of liquid-like nuclear bodies and prolongs the untranslated regions of specific transcripts, leading to late flowering and ABA hypersensitivity.

MOLECULAR PLANT (2021)

Article Biochemistry & Molecular Biology

CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis

Yifeng Hou et al.

Summary: The study demonstrates that m(6)A modification regulates APA in plants, with CPSF30-L YTH domain binding to m(6)A and affecting nitrate signaling by controlling APA.

MOLECULAR PLANT (2021)

Article Plant Sciences

N6-Methyladenosine mRNA methylation is important for salt stress tolerance in Arabidopsis

Jianzhong Hu et al.

Summary: This study reveals that m(6)A methylation plays a crucial role in salt stress tolerance in Arabidopsis, with mutants of m(6)A writer components showing salt-sensitive phenotypes. It was demonstrated that VIR-mediated m(6)A methylation modulates reactive oxygen species homeostasis and mRNA stability of salt stress negative regulators. The findings highlight the important role of epitranscriptomic mRNA methylation in Arabidopsis salt stress response and its relationship with 3'UTR length and mRNA stability during stress adaptation.

PLANT JOURNAL (2021)

Article Multidisciplinary Sciences

R-loop resolution promotes co-transcriptional chromatin silencing

Congyao Xu et al.

Summary: RNA-mediated chromatin silencing plays a central role in genome regulation across various organisms. In this study, researchers demonstrated that resolution of an R-loop during 3'-end processing of a plant antisense transcript recruits chromatin modifiers to promote chromatin silencing. Additionally, modulation of R-loop stability by co-transcriptional RNA processing can trigger chromatin silencing.

NATURE COMMUNICATIONS (2021)

Article Biology

Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA

Matthew T. Parker et al.

Summary: Genes involved in disease resistance, such as the nucleotide-binding, leucine-rich repeat (NLR) genes in plant genomes, play crucial roles but can also have negative impacts. Research shows that the RNA-binding protein FPA controls NLR transcript processing and gene annotation, revealing a co-transcriptional layer of NLR regulation with implications for plant immune responses.

ELIFE (2021)

Article Biochemistry & Molecular Biology

OsEDM2L mediates m(6)A of EAT1 transcript for proper alternative splicing and polyadenylation regulating rice tapetal degradation

Kun Ma et al.

Summary: N-6-methyladenosine (m(6)A)) modification plays a crucial role in post-transcriptional regulation of eukaryotic gene expression, with OsEDM2L identified as a key protein essential for rice anther development through regulating the m(6)A modification of EAT1 mRNA to impact tapetal programmed cell death.

JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2021)

Article Biotechnology & Applied Microbiology

RNA demethylation increases the yield and biomass of rice and potato plants in field trials

Qiong Yu et al.

Summary: The transgenic expression of human RNA demethylase FTO in rice and potato significantly increased grain yield and biomass, stimulated root meristem cell proliferation and tiller bud formation, and improved photosynthetic efficiency and drought tolerance. FTO mediates substantial m(6)A demethylation in plant RNA, leading to chromatin openness and transcriptional activation. Modulation of plant RNA m(6)A methylation is a promising strategy for improving plant growth and crop yield.

NATURE BIOTECHNOLOGY (2021)

Article Biochemical Research Methods

Multiplexed profiling facilitates robust m6A quantification at site, gene and sample resolution

David Dierks et al.

Summary: m6A-seq2 is a method that uses multiplexed N-6-methyladenosine immunoprecipitation to compare m6A levels at the site, gene, and sample level, increasing throughput and reducing technical variability and cost. It provides sample-level relative quantitation of m6A and gene-level quantitation, showing that m6A is a main driver of RNA stability in mouse embryonic stem cells.

NATURE METHODS (2021)

Article Plant Sciences

Alpha-ketoglutarate-dependent dioxygenase homolog 10B, an N6-methyladenosine, plays a role in salt stress and abscisic acid responses in Arabidopsis thaliana

Yasira Shoaib et al.

Summary: ALKBH10B-mediated m(6)A demethylation affects the transcript levels of stress-responsive genes important for seed germination, seedling growth, and survival of Arabidopsis thaliana in response to salt stress or ABA.

PHYSIOLOGIA PLANTARUM (2021)

Article Plant Sciences

ALKBH10B, an mRNA m6A Demethylase, Modulates ABA Response During Seed Germination in Arabidopsis

Jun Tang et al.

Summary: The epitranscriptomic mark N-6-methyladenine (m(6)A) regulates plant development and stress response. ALKBH10B, an mRNA m(6)A demethylase in Arabidopsis, was found to negatively modulate the ABA response during seed germination. Transcriptome analysis revealed upregulation of ABA response genes in the alkbh10b mutants, indicating a role of ALKBH10B in plant stress responses.

FRONTIERS IN PLANT SCIENCE (2021)

Article Plant Sciences

Transcriptome-Wide Analysis of RNA m6A Methylation and Gene Expression Changes Among Two Arabidopsis Ecotypes and Their Reciprocal Hybrids

Zhihui Xu et al.

Summary: The majority of m(6)A methylation is maintained after hybridization, and the enriched biological functions of genes with differential m(6)A modification between parents and hybrids are conserved, revealing a potential new layer of regulatory mechanisms.

FRONTIERS IN PLANT SCIENCE (2021)

Article Plant Sciences

A photoregulatory mechanism of the circadian clock in Arabidopsis

Xu Wang et al.

Summary: CRYs play various functions in plants and animals, including photoperception and circadian regulation; blue light induces liquid-liquid phase separation of CRY2, altering the epitranscriptome of mRNA, especially those related to the circadian clock; light-induced phase separation of CRYs modulates mRNA methylation and circadian rhythms in plants.

NATURE PLANTS (2021)

Article Biotechnology & Applied Microbiology

The dynamics of N6-methyladenine RNA modification in interactions between rice and plant viruses

Kun Zhang et al.

Summary: We found that m(6)A methylation in virus-infected rice plants is mainly associated with genes that are not actively expressed. Additionally, different m(6)A peak distributions on the same gene may contribute to different antiviral modes. The level of m(6)A methylation is tightly associated with gene expression levels, especially in key antiviral pathways.

GENOME BIOLOGY (2021)

Article Biotechnology & Applied Microbiology

N6-methyladenosine RNA modification regulates strawberry fruit ripening in an ABA-dependent manner

Leilei Zhou et al.

Summary: The study reveals that m(6)A methylation undergoes significant changes during strawberry ripening, mainly regulating the process by stabilizing mRNAs, particularly in the CDS regions. Methyltransferases MTA and MTB are essential for normal ripening of strawberry fruit, and m(6)A modification also promotes stability of certain transcripts related to the ABA pathway.

GENOME BIOLOGY (2021)

Article Biotechnology & Applied Microbiology

Quantitative profiling of N6-methyladenosine at single-base resolution in stem-differentiating xylem of Populus trichocarpa using Nanopore direct RNA sequencing

Yubang Gao et al.

Summary: The study introduces a new pipeline, Nanom6A, for the identification and quantification of m(6)A modification at single-base resolution, providing transcriptome-wide quantification of m(6)A modification in stem-differentiating xylem.

GENOME BIOLOGY (2021)

Article Plant Sciences

Evolution of the RNA N6-Methyladenosine Methylome Mediated by Genomic Duplication

Zhenyan Miao et al.

PLANT PHYSIOLOGY (2020)

Editorial Material Biochemistry & Molecular Biology

H3K36me2 is highly correlated with m(6)A modifications in plants

Sangrea Shim et al.

JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine

Ye Wang et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method

Marcel Bach-Pages et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

Jiexin Li et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

Functional Characterization of a Putative RNA Demethylase ALKBH6 in Arabidopsis Growth and Abiotic Stress Responses

Trinh Thi Huong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana

Susheel Sagar Bhat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biochemistry & Molecular Biology

Detection methods of epitranscriptomic mark N6-methyladenosine

Ye Wang et al.

SPOTLIGHT ON CHINA: RNA (2020)

Article Biochemistry & Molecular Biology

Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

Xiao-Min Liu et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Biotechnology & Applied Microbiology

RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening

Leilei Zhou et al.

GENOME BIOLOGY (2019)

Article Biochemistry & Molecular Biology

An m(6)A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis([OPEN])

Laura Arribas-Hernandez et al.

PLANT CELL (2018)

Article Biochemistry & Molecular Biology

The m6A Reader ECT2 Controls Trichome Morphology by Affecting mRNA Stability in Arabidopsis[OPEN]

Lian-Huan Wei et al.

PLANT CELL (2018)

Article Biochemistry & Molecular Biology

The YTH Domain Protein ECT2 Is an m(6)A Reader Required for Normal Trichome Branching in Arabidopsis([OPEN])

Jeremy Scutenaire et al.

PLANT CELL (2018)

Review Biochemical Research Methods

Epitranscriptome sequencing technologies: decoding RNA modifications

Xiaoyu Li et al.

NATURE METHODS (2017)

Article Biochemistry & Molecular Biology

ALKBH10B Is an RNA N6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition

Hong-Chao Duan et al.

PLANT CELL (2017)

Article Multidisciplinary Sciences

Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs

Mireya Martinez-Perez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Letter Cell Biology

Cytoplasmic m6A reader YTHDF3 promotes mRNA translation

Ang Li et al.

CELL RESEARCH (2017)

Article Microbiology

Dynamics of Human and Viral RNA Methylation during Zika Virus Infection

Gianluigi Lichinchi et al.

CELL HOST & MICROBE (2016)

Article Microbiology

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

Nandan S. Gokhale et al.

CELL HOST & MICROBE (2016)

Article Biochemistry & Molecular Biology

Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

Wen Xiao et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

Junhong Choi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

Junhong Choi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Microbiology

Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells

Gianluigi Lichinchi et al.

NATURE MICROBIOLOGY (2016)

Article Biochemistry & Molecular Biology

5′ UTR m6A Promotes Cap-Independent Translation

Kate D. Meyer et al.

Article Biochemistry & Molecular Biology

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

Claudio R. Alarcon et al.

Article Biochemistry & Molecular Biology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang et al.

Article Biochemical Research Methods

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

Bastian Linder et al.

NATURE METHODS (2015)

Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

Chao Xu et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Multidisciplinary Sciences

Unique features of the m6A methylome in Arabidopsis thaliana

Guan-Zheng Luo et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

Article Multidisciplinary Sciences

Novel AlkB Dioxygenases-Alternative Models for In Silico and In Vivo Studies

Damian Mielecki et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Plant Sciences

Identification of genes required for embryo development in Arabidopsis

I Tzafrir et al.

PLANT PHYSIOLOGY (2004)