An opinion on Wastewater-Based Epidemiological Monitoring (WBEM) with Clinical Diagnostic Test (CDT) for detecting high-prevalence areas of community COVID-19 infections

Review Environmental Sciences

Monkeypox outbreak: Wastewater and environmental surveillance perspective

Ananda Tiwari et al.

Summary: Monkeypox disease, caused by the monkeypox virus, has become a global concern. Wastewater-based surveillance can be a useful tool for early detection of the virus, but there are challenges to overcome.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Review Environmental Sciences

SARS-CoV-2 and other pathogens in municipal wastewater, landfill leachate, and solid waste: A review about virus surveillance, infectivity, and inactivation

Uttpal Anand et al.

Summary: This review discusses the techniques available for detecting and inactivating pathogens in municipal wastewater, landfill leachate, and solid waste, with special attention given to SARS-CoV-2 and its transmission pathways in waste matrices. The systematic analysis method used in this study allows for a focus on technologies for pathogen detection and treatment, highlighting the need for further investigation into virus infectivity and transmission mechanisms.

ENVIRONMENTAL RESEARCH (2022)

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Article Environmental Sciences

Acquired insights from the long-term surveillance of SARS-CoV-2 RNA for COVID-19 monitoring: The case of Monterrey Metropolitan Area (Mexico)

Diego A. Padilla-Reyes et al.

Summary: Wastewater-based epidemiology is an effective and cost-effective method for monitoring the spread of SARS-CoV-2, providing early warning of outbreaks in the population. The study found a correlation between viral load in wastewater and clinical cases, with wastewater surveillance able to provide a 2-7 day early warning. The detection rate of SARS-CoV-2 in wastewater was relatively low, with one detection for every 14,300 reported new cases. Prevalence estimates during the study period ranged from 0.02% to 4.6%. The application of wastewater-based epidemiology for COVID-19 surveillance is generally consistent and feasible, with room for improvement.

ENVIRONMENTAL RESEARCH (2022)

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Article Environmental Sciences

Development of an efficient wastewater testing protocol for high-throughput country-wide SARS-CoV-2 monitoring

Diyar Mailepessov et al.

Summary: Wastewater-based surveillance is a widely used non-intrusive tool for monitoring population-level transmission of COVID-19. This study aimed to identify and evaluate SARS-CoV-2 virus concentration protocols for high-throughput wastewater testing. The results showed that optimal virus recovery was achieved by removing debris, incubating with 8% PEG at 4 degrees C, centrifugation, and column-based RNA extraction methods.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

A wastewater-based epidemiology tool for COVID-19 surveillance in Portugal

Silvia Monteiro et al.

Summary: This study monitored the trends of SARS-CoV-2 RNA circulation in wastewater in Portugal during different epidemiological phases of the pandemic. The findings highlight the value of wastewater-based epidemiology (WBE) as a surveillance tool for early warning of COVID-19 outbreaks and its synchrony with actual case trends.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Relating SARS-CoV-2 shedding rate in wastewater to daily positive tests data: A consistent model based approach

M. Petala et al.

Summary: During the COVID-19 pandemic, wastewater-based epidemiology (WBE) has been used to complement medical surveillance and act as an early diagnosis indicator. A mathematical model was developed to estimate the evolution of virus shedding rate in wastewater based on daily positive medical tests. The study showed that WBE can be used as an early warning tool for predicting pandemic outbreaks, with an average early warning capacity of around 2 days in the city of Thessaloniki. Additionally, the detection capacity of WBE improves with an increasing number of unreported cases, reaching a maximum of 4 times the reported cases during the peak of the pandemic in mid-November 2020.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Microbiology

Bacillus spp. Contamination: A Novel Risk Originated From Animal Feed to Human Food Chains in South-Eastern Bangladesh

Md Atiqul Haque et al.

Summary: This study provides information on the contamination of Bacillus spp. in commercially available poultry and animal feeds, as well as animal-derived products in Bangladesh. The research findings indicate a high prevalence of Bacillus spp. contamination in these samples, with a significant number of isolates carrying virulence genes that pose a threat to human health. The study highlights the urgent need for establishing maximum tolerance limits and addressing the potential risks of Bacillus spp. in the animal industry.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Arachidonic acid supplementation attenuates adipocyte inflammation but not adiposity in high fat diet induced obese mice

Sourav Roy et al.

Summary: This study investigated the effects of arachidonic acid (AA) supplementation on obesity, adipocyte morphology, inflammation, and AA cascade signaling. The results suggest that AA does not significantly affect body weight, visceral fat mass, or serum lipid profile. However, it effectively alleviates obesity-induced adipocyte inflammation in high-fat diet-induced obese mice.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Environmental Sciences

Comparison of virus concentration methods and RNA extraction methods for SARS-CoV-2 wastewater surveillance

Xiawan Zheng et al.

Summary: Wastewater surveillance is a promising tool for monitoring the spread of COVID-19, and this study evaluated different virus concentration methods for the detection of SARS-CoV-2 in wastewater. Ultracentrifugation was found to be the most effective method, and lysis-buffer-based extraction method resulted in higher viral recovery efficiencies.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Use of sewage surveillance for COVID-19 to guide public health response: A case study in Hong Kong

Yu Deng et al.

Summary: This study demonstrates the use of intensified sewage surveillance to identify a Delta variant outbreak in Hong Kong, highlighting the importance of proactive public health measures. The findings suggest that sewage surveillance can play a crucial role in preventing and controlling the spread of COVID-19.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Engineering, Environmental

Metrics to relate COVID-19 wastewater data to clinical testing dynamics

Amy Xiao et al.

Summary: Wastewater surveillance is a useful tool in the public health response to the COVID-19 pandemic. Quantitative metrics are needed to interpret wastewater data in the context of public health trends. Three new metrics have been demonstrated to monitor changes in COVID-19 epidemiology.

WATER RESEARCH (2022)

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Review Immunology

A Review on Measures to Rejuvenate Immune System: Natural Mode of Protection Against Coronavirus Infection

Md. Aminul Islam et al.

Summary: SARS-CoV-2, a novel coronavirus strain, has caused a devastating global outbreak with millions of deaths and infections. The human immune system plays a critical role in fighting against the virus, and measures such as dietary supplements, medicinal plants, and personal habits can help strengthen the immune system and prevent viral infection.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Environmental Sciences

Wastewater-based epidemiological surveillance to monitor the prevalence of SARS-CoV-2 in developing countries with onsite sanitation facilities

Md Jakariya et al.

Summary: The study collected wastewater samples from urban and rural areas in Bangladesh and detected SARS-CoV-2 genetic materials, providing important evidence for monitoring the COVID-19 pandemic. By analyzing wastewater samples from different locations such as markets and isolation centers, suitable sampling sites for detecting contagion hotspots were identified.

ENVIRONMENTAL POLLUTION (2022)

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Article Environmental Sciences

Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests

Juan Eduardo Sosa-Hernandez et al.

Summary: This study is the first long-term wastewater-based epidemiology research in Mexico, which demonstrates the value of wastewater monitoring in predicting the trend of COVID-19 infections.

WATER (2022)

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Article Biochemistry & Molecular Biology

Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice

Sourav Roy et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2022)

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Letter Surgery

Zoonotic concerns of Marburg virus: Current knowledge and counteracting strategies including One Health approach to limit animal-human interface: An update

Kuldeep Dhama et al.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Letter Surgery

\ Monkeypox vaccines and vaccination strategies: Current knowledge and advances. An update

Sandip Chakraborty et al.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Letter Surgery

Deep learning research should be encouraged for diagnosis and treatment of antibiotic resistance of microbial infections in treatment associated emergencies in hospitals

Chiranjib Chakraborty et al.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Article Environmental Sciences

Wastewater surveillance of SARS-CoV-2 in Bangladesh: Opportunities and challenges

Rehnuma Haque et al.

Summary: The ongoing COVID-19 pandemic can be monitored by testing symptomatic individuals or by analyzing viral genetic materials in wastewater. Environmental surveillance provides advantages, especially in densely populated areas. However, there are challenges in sampling, laboratory analysis, hydraulic flows, and collaborative efforts.

CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH (2022)

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Article Environmental Sciences

Detection and quantification of SARS-CoV-2 RNA in wastewater and treated effluents: Surveillance of COVID-19 epidemic in the United Arab Emirates

Shadi W. Hasan et al.

Summary: Testing SARS-CoV-2 viral loads in wastewater in the United Arab Emirates revealed fluctuating levels in different locations, with government precautionary measures correlating with a decrease in viral loads. None of the 11 wastewater treatment plants' effluents tested positive, indicating the efficiency of treatment technologies in degrading the virus and the safety of treated reused water.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Biotechnology & Applied Microbiology

Time Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Wastewater during the First Pandemic Wave of COVID-19 in the Metropolitan Area of Barcelona, Spain

Gemma Chavarria-Miro et al.

Summary: The study showed that monitoring SARS-CoV-2 in wastewater in Barcelona helped anticipate the COVID-19 pandemic situation, demonstrating the usefulness of water-based epidemiology as a tool for tracking virus circulation and aiding health authorities in taking timely measures.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2021)

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Article Engineering, Environmental

SARS-CoV-2 RNA in Wastewater Settled Solids Is Associated with COVID-19 Cases in a Large Urban Sewershed

Katherine E. Graham et al.

Summary: The study indicates that measuring SARS-CoV-2 RNA concentrations in settled solids may be a more sensitive approach than measuring SARS-CoV-2 in influent, providing important information for public health response to viral diseases like COVID-19.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

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Article Environmental Sciences

Detection of SARS-CoV-2 in raw and treated wastewater in Germany - Suitability for COVID-19 surveillance and potential transmission risks

Sandra Westhaus et al.

Summary: Wastewater-based monitoring showed the presence of SARS-CoV-2 genetic traces in different raw wastewaters in North Rhine-Westphalia, Germany. However, it was suggested that wastewater might not be a major route for transmission to humans. Further validation for enveloped viruses in wastewater is needed.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Review Medicine, General & Internal

Point of Care Diagnostics in the Age of COVID-19

Meysam Rezaei et al.

Summary: The article discusses the global health threat posed by the novel coronavirus pandemic and the importance of point-of-care testing in improving healthcare. Due to the limitations of standard diagnostic methods, POC testing has become an important development direction in the field of healthcare.

DIAGNOSTICS (2021)

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Article Biochemistry & Molecular Biology

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Daming Zhou et al.

Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.

CELL (2021)

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Article Environmental Sciences

Detection of SARS-CoV-2 variants by genomic analysis of wastewater samples in Israel

Itay Bar-Or et al.

Summary: Monitoring SARS-CoV-2 variants in wastewater can accurately detect the prevalence of viral strains and assist in monitoring the diversity of circulating strains in the community, as well as pre-identify the emergence of relevant mutations or variants.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Prevalence of SARS-CoV-2 genes in water reclamation facilities: From influent to anaerobic digester

Bishav Bhattarai et al.

Summary: The study found that gene copy numbers of SARS-CoV-2 tend to concentrate in primary clarifier sludges before being removed through sedimentation. The gene copy numbers in influent and RAS are significantly correlated with the number of COVID-19 cases, indicating their potential for epidemiological monitoring. This research provides valuable insights into the dynamics of SARS-CoV-2 gene copy numbers in biosolids and their relationship with reported COVID-19 cases throughout the wastewater treatment process.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Wastewater surveillance-based city zonation for effective COVID-19 pandemic preparedness powered by early warning: A perspectives of temporal variations in SARS-CoV-2-RNA in Ahmedabad, India

Manish Kumar et al.

Summary: This study conducted a three-month wastewater surveillance in Ahmedabad, India, and found variations in SARS-CoV-2 RNA concentration in different months, showing some correlation with the number of COVID-19 cases in the area.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Monitoring of SARS-CoV-2 RNA in wastewater as an epidemiological surveillance tool in Mendoza, Argentina

Maximiliano Giraud-Billoud et al.

Summary: Wastewater-based epidemiology (WBE) is an emerging tool that provides temporal and spatial information on a population's health status. By combining WBE with epidemiological surveillance, researchers were able to track the dynamics of COVID-19 infections, showing a positive correlation between viral load in wastewater and diagnosed cases. WBE proves to be a useful epidemiological indicator for anticipating COVID-19 case increases and monitoring the pandemic's progress and different waves of infections.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

SARS-CoV-2 RNA monitoring in wastewater as a potential early warning system for COVID-19 transmission in the community: A temporal case study

Warish Ahmed et al.

Summary: Detection of SARS-CoV-2 RNA in wastewater can serve as an early warning system to identify viral hotspots and target localized public health responses. This method provides unique information on asymptomatic and pre-symptomatic cases that may not be captured by clinical testing, showing potential for effective disease surveillance.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

First confirmed detection of SARS-COV-2 in untreated municipal and aircraft wastewater in Dubai, UAE: The use of wastewater based epidemiology as an early warning tool to monitor the prevalence of COVID-19

Abdulla Albastaki et al.

Summary: The emergence of SARS-CoV-2 from Wuhan, China led to a global pandemic, with research showing high positive rates in stool samples in Dubai. Monitoring through wastewater systems may assist decision-makers in determining appropriate precautions based on outbreak areas.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Detection of SARS-CoV-2 RNA in hospital wastewater from a low COVID-19 disease prevalence area

Jose Goncalves et al.

Summary: Previous studies have reported the presence of viral RNA in stool samples from individuals with SARS-CoV and MERS-CoV, suggesting that wastewater from affected communities may contain SARS-CoV-2 RNA. Recent studies have also found SARS-CoV-2 RNA in human feces. Wastewater-based epidemiology is a promising approach to monitor the prevalence of COVID-19 in communities, as demonstrated by the first detection of SARS-CoV-2 RNA in untreated wastewater in Slovenia.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Detection of SARS-CoV-2 in wastewater in Japan during a COVID-19 outbreak

Akihiko Hata et al.

Summary: The study in Japan found that SARS-CoV-2 RNA could be detected in wastewater samples, even at low numbers of confirmed cases, indicating the potential for early detection of impending outbreaks. This suggests that wastewater-based epidemiology may serve as an early warning system for COVID-19 outbreaks.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

COVID-19 containment on a college campus via wastewater-based epidemiology, targeted clinical testing and an intervention

Walter Q. Betancourt et al.

Summary: Wastewater-based epidemiology has shown potential as an early-warning tool for detecting the presence of COVID-19 in communities. By utilizing wastewater testing, infected individuals were identified and isolated, thereby preventing potential disease transmission.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Engineering, Environmental

Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19

Fredy Saguti et al.

Summary: The study revealed that SARS-CoV-2 can be detected in wastewater, and its levels reflect the extent of transmission in society. Viral peaks occurred approximately every four weeks, preceding fluctuations in newly hospitalized patients by 19-21 days. Local differences in viral spread were observed, with varying amounts of virus found in wastewater from different areas of the same city, possibly reflecting the transmission patterns of infected individuals.

WATER RESEARCH (2021)

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Article Multidisciplinary Sciences

Long-term monitoring of SARS-CoV-2 RNA in wastewater of the Frankfurt metropolitan area in Southern Germany

Shelesh Agrawal et al.

Summary: Wastewater-based epidemiology is an effective method to monitor the scale and dynamics of infections in a city, with the SARS-CoV-2 RNA concentration in raw sewage in the Frankfurt metropolitan area showing a resurgence in August. This suggests a continuous increase in COVID-19 cases in Frankfurt.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Development of Wastewater Pooled Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from Congregate Living Settings

Lisa M. Colosi et al.

Summary: Wastewater-based monitoring for SARS-CoV-2 at the individual building level is efficient for early detection, but cannot distinguish new infectious cases from convalescent shedding. Further refinement is needed to enhance the ability to differentiate between the two.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2021)

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Article Environmental Sciences

Unravelling the early warning capability of wastewater surveillance for COVID-19: A temporal study on SARS-CoV-2 RNA detection and need for the escalation

Manish Kumar et al.

Summary: Wastewater-based Epidemiological (WBE) surveillance is a promising method to assess the pandemic situation in highly populated areas with limited clinical tests. This study in Gandhinagar, India found SARS-CoV-2 RNA in wastewater samples, demonstrating the potential of WBE surveillance to predict COVID-19 case fluctuations.

ENVIRONMENTAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Enhanced binding of the N501Y-mutated SARS-CoV-2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations

Binquan Luan et al.

Summary: Recently emerged SARS-CoV-2 variants with mutations, such as N501Y, may enhance binding to hACE2. Molecular dynamics simulations show that Y501 in the mutated RBD can interact with Y41 and K353 in hACE2, potentially increasing the overall binding affinity by approximately 0.81 kcal center dot mol(-1). This binding dynamics may aid in designing more effective antibodies.

FEBS LETTERS (2021)

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Article Public, Environmental & Occupational Health

Epidemiological surveillance of SARS-CoV-2 by genome quantification in wastewater applied to a city in the northeast of France: Comparison of ultrafiltration- and protein precipitation-based methods

Isabelle Bertrand et al.

Summary: The study developed a method to quantify the SARS-CoV-2 genome in wastewater and used phages as an internal control. Results showed a decrease in SARS-CoV-2 genome concentration in wastewater during lockdown, consistent with a decrease in COVID-19 cases detected in respiratory samples. Such environmental surveillance is crucial for predicting the circulation of the virus in the community.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2021)

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Article Multidisciplinary Sciences

Understanding the clinical and demographic characteristics of second coronavirus spike in 192 patients in Tehran, Iran: A retrospective study

Hamid Zaferani Arani et al.

Summary: During the last months of the coronavirus pandemic, Iran faced the second wave of COVID-19 due to lack of appropriate public restrictions, leading to an increase in severe cases. The study found that age, BMI, and affected family members were statistically associated with disease severity in COVID-19 patients, with patients with comorbidities requiring more hospitalization and medical care. The research also suggested that the effectiveness of IFB (Betamethasone) was greater than other alternative drugs such as LPV/r and IVIg.

PLOS ONE (2021)

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Article Environmental Sciences

Efficient detection of SARS-CoV-2 RNA in the solid fraction of wastewater

Kouichi Kitamura et al.

Summary: In the context of the COVID-19 pandemic, efficient detection of SARS-CoV-2 RNA in the solid fraction of wastewater was investigated using two quantitative PCR assays. Results showed higher concentrations of SARS-CoV-2 RNA in the solid fractions compared to the supernatant fractions, demonstrating an effective method for surveillance in an aqueous environment.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations

Patrick M. D'Aoust et al.

Summary: The study found that wastewater surveillance of COVID-19 can help predict increases in community cases and hospitalizations, providing an important complement to diagnostic testing in public health efforts.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Engineering, Environmental

Monitoring SARS-CoV-2 in municipal wastewater to evaluate the success of lockdown measures for controlling COVID-19 in the UK

Luke S. Hillary et al.

Summary: The study demonstrates that SARS-CoV-2 RNA levels in wastewater generally corresponded with the number of clinical cases in large urban centers, decreasing significantly after lockdown measures were implemented. Genetic sequencing of the virus in wastewater revealed multiple distinct clusters circulating in the local population, reflecting similarities with SNPs found in clinical samples. The findings suggest that wastewater-based epidemiology can be a valuable tool for monitoring and tracking the prevalence of SARS-CoV-2 and other viruses in the community, aiding in public health policy decisions.

WATER RESEARCH (2021)

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Article Medicine, General & Internal

Rapid point-of-care testing for COVID-19: quality of supportive information for lateral flow serology assays

Patrick Kierkegaard et al.

Summary: The study used content analysis to evaluate the quality of supportive information provided by commercial manufacturers for POCTs, revealing significant variations in information quality and lack of detail. The findings suggest poor information transparency and inadequate addressing of human factor issues, calling for manufacturers to improve the quality of information in their supporting documentation.

BMJ OPEN (2021)

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Review Environmental Sciences

Prevalence of SARS-CoV-2 in Communities Through Wastewater Surveillance-a Potential Approach for Estimation of Disease Burden

Prosun Bhattacharya et al.

Summary: The episodic outbreak of COVID-19 caused by SARS-CoV-2 has led to a significant impact on the global economy, with an increasing number of infected patients. Recent studies have shown that tracking the viral RNA of SARS-CoV-2 in human feces can help monitor the prevalence and trends of the disease in communities, offering new possibilities for managing pandemics. New emerging economies with high population density face additional challenges due to limited testing facilities, highlighting the importance of innovative approaches like wastewater-based epidemiology.

CURRENT POLLUTION REPORTS (2021)

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Review Medicine, General & Internal

Review of Current COVID-19 Diagnostics and Opportunities for Further Development

Yan Mardian et al.

Summary: Diagnostic testing is crucial in addressing the COVID-19 pandemic caused by SARS-CoV-2, with nucleic acid amplification tests being the primary method for confirmation of infection. However, challenges such as false negatives and positives highlight the importance of considering clinical presentation, contact history, and epidemiologic characteristics when interpreting results. Additional testing platforms and technologies are being developed to improve testing capacity and accuracy.

FRONTIERS IN MEDICINE (2021)

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Article Biology

Computational screening of 645 antiviral peptides against the receptor-binding domain of the spike protein in SARS-CoV-2

Md Minhas Hossain Sakib et al.

Summary: The study found that peptides may be effective drugs against SARS-CoV-2, with AVP1795 identified as the most promising candidate that could inhibit the recognition of SARS-CoV-2 by hACE2 as predicted by molecular dynamics simulation. Peptide-protein interactions were substantially influenced by hydrogen bonding and hydrophobic interactions.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

Jackson S. Turner et al.

Summary: SARS-CoV-2 mRNA vaccines induce a persistent germinal centre B cell response in humans, leading to the generation of robust humoral immunity, especially more significant in individuals previously infected with the virus.

NATURE (2021)

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Article Multidisciplinary Sciences

A fast link between face perception and memory in the temporal pole

Sofia M. Landi et al.

Summary: Through recordings from an area in the macaque temporal pole identified with functional magnetic resonance imaging, cells have been discovered that respond specifically to familiar faces, discriminating between familiar identities at a rapid pace. This finding establishes a new pathway for the swift recognition of familiar individuals.

SCIENCE (2021)

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Article Environmental Sciences

COVID-19 (SARS-CoV-2) outbreak monitoring using wastewater-based epidemiology in Qatar

Jayaprakash Saththasivam et al.

Summary: Sampling raw wastewater from major treatment plants in Qatar, it was found that there was a significant discrepancy between the estimated number of infected people and the officially reported cases. Wastewater-based epidemiology proved to be a more reliable method for assessing the true incidence trend in the population.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Monitoring changes in COVID-19 infection using wastewater-based epidemiology: A South African perspective

Leanne Pillay et al.

Summary: This study demonstrates the application of wastewater-based epidemiology in monitoring COVID-19 infection dynamics in KwaZulu-Natal province of South Africa, showing that the peak viral load corresponds to local infection cases and that easing of lockdown restrictions correlates with an increase in viral load in untreated wastewater.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Implementing building-level SARS-CoV-2 wastewater surveillance on a university campus

Cynthia Gibas et al.

Summary: The COVID-19 pandemic poses increased risks of illness in group environments, prompting interest in wastewater-based epidemiology as a tool for outbreak mitigation. A pilot program at UNC Charlotte demonstrated the effectiveness of wastewater surveillance in detecting asymptomatic cases and complementing existing monitoring strategies on campus.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Correlation of SARS-CoV-2 RNA in wastewater with COVID-19 disease burden in sewersheds

Jennifer Weidhaas et al.

Summary: The study found that SARS-CoV-2 RNA can be detected in wastewater, and highlighted the utility of wastewater epidemiology in assisting public health responses to COVID-19.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

First detection of SARS-CoV-2 genetic material in the vicinity of COVID-19 isolation Centre in Bangladesh: Variation along the sewer network

Firoz Ahmed et al.

Summary: The study successfully detected SARS-CoV-2 genetic material in the vicinity wastewaters of an isolation centre in Southeastern Bangladesh, with accumulation of SARS-CoV-2 RNA in the main sewer observed. The findings suggest that monitoring major drains may illustrate the health status of the city, eliminating the need to monitor every wastewater system.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Engineering, Environmental

A multicenter study investigating SARS-CoV-2 in tertiary-care hospital wastewater. viral burden correlates with increasing hospitalized cases as well as hospital-associated transmissions and outbreaks

Nicole Acosta et al.

Summary: This study utilized wastewater-based detection of SARS-CoV-2 to assess the epidemiology of SARS-CoV-2 in hospitals. The results showed an increasing trend of N1 and N2 genes in wastewater over time in hospitals with single monitoring points, correlating with the rise in hospitalizations. Despite increasing hospitalizations, the detection of SARS-CoV-2 N1-RNA in wastewater was able to differentiate nosocomial-acquired cases of COVID-19 and unit-specific outbreaks. Wastewater-based monitoring of SARS-CoV-2 is a promising tool for passive surveillance and case identification, containment, and mitigation in acute-care medical facilities.

WATER RESEARCH (2021)

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Article Engineering, Environmental

Assessing spatial distribution of COVID-19 prevalence in Brazil using decentralised sewage monitoring

Cesar R. Mota et al.

Summary: This study assesses the distribution of COVID-19 prevalence in Brazilian cities by monitoring SARS-CoV-2 RNA in sewage, identifying that the most vulnerable neighborhoods in the city were hit hardest by the pandemic. This indicates that the situation for many Brazilians is much worse than reported by official figures.

WATER RESEARCH (2021)

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Review Microbiology

Sewage Systems Surveillance for SARS-CoV-2: Identification of Knowledge Gaps, Emerging Threats, and Future Research Needs

Fatemeh Amereh et al.

Summary: This systematic review provides an overview of the occurrence and methods for detecting SARS-CoV-2 in wastewater, emphasizing the importance of wastewater-based epidemiology (WBE) as a new paradigm in public health. Areas for improvement include sampling procedures, concentration/enrichment, detection, and quantification of virus. More accurate population estimation methods for WBE studies and cross-validation of estimates are still challenges. Wastewater surveillance can be valuable for early warning, management, and investigating vaccination efficacy and spread of new variants.

PATHOGENS (2021)

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Review Engineering, Environmental

Wastewater-Based Epidemiology for Community Monitoring of SARS-CoV-2: Progress and Challenges

Teresa Kumblathan et al.

Summary: Wastewater-based epidemiology is useful for monitoring SARS-CoV-2 in communities, but efficient sample processing and sensitive detection of viral RNA still pose challenges, requiring further research efforts for the development and standardization of methods.

ACS ENVIRONMENTAL AU (2021)

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Article Engineering, Environmental

Early-pandemic wastewater surveillance of SARS-CoV-2 in Southern Nevada: Methodology, occurrence, and incidence/prevalence considerations

Daniel Gerrity et al.

Summary: The study aimed to compare virus recovery and detection methods, detect and quantify SARS-CoV-2 genetic material in two sewersheds in Southern Nevada, and understand the link between COVID-19 incidence/prevalence and wastewater concentrations of SARS-CoV-2 RNA. Different methods and target water matrices led to varying virus recovery rates and sample volumes, impacting sensitivity and reported concentrations. Composite sampling showed a significant increase in concentration compared to grab samples, indicating diurnal variability in SARS-CoV-2 signal. Detection and quantification of genetic markers in sewage showed comparability with public health data in early pandemic stages.

WATER RESEARCH X (2021)

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Review Medicine, General & Internal

Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus 2 A Narrative Review

Matthew P. Cheng et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Review Anesthesiology

Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore

Jolin Wong et al.

CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE (2020)

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Article Immunology

Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19)

Jasper Fuk-Woo Chan et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Letter Respiratory System

No association of COVID-19 transmission with temperature or UV radiation in Chinese cities

Ye Yao et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Gastroenterology & Hepatology

Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis

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