Boosting the Immunoactivity of T Cells by Resonant Thermal Radiation from Electric Graphene Films for Improved Cancer Immunotherapy

To investigate the effect of resonant thermal radiation from electric graphene films (GFs) to the immunoactivity of T cells in situ and the benefits to cancer immunotherapy. This work utilizes externally applied GFs to regulate the immunoactivity of T cells through the eminent resonant thermal radiation effect. The GFs are fabricated with high emissivity and well-matched far-infrared emission peaks between the GFs and living bodies. The T-cell antigen receptor signaling mechanisms and the ensuing immunoactivity of T cells by GFs treatment, compared with traditional metal films (MFs), are studied both in vitro and in vivo. The resonance thermal radiation decreases the activation threshold of T cells by increasing the influx of calcium ions, neutralizing the negative charge of intracellular membranes and triggering the phospho-CD3 zeta event. As a result, GF treatment elicits an enhanced T-cell-based immune response and serves as an externally applied adjuvant to T-cell activation, which shows remarkable efficiency in combination with aPD-L1 immunotherapy in multiple mouse models. This work centers the unmet needs of regulating the immunoactivity of intratumoral T cells in situ, in which the auxiliary use of GFs with high efficiency and little safety concern has great promise to translational study regarding cancer immunotherapy in future.

Automated summary

This study investigates the impact of resonant thermal radiation from electric graphene films (GFs) on the immunoactivity of T cells and its potential benefits for cancer immunotherapy. The findings demonstrate that externally applied GFs can regulate the immunoactivity of T cells through resonant thermal radiation, resulting in an enhanced T-cell-based immune response. The combination of GF treatment and aPD-L1 immunotherapy shows remarkable efficacy in multiple mouse models.