3.8 Article

Missed Cystic Fibrosis Newborn Screening Cases due to Immunoreactive Trypsinogen Levels below Program Cutoffs: A National Survey of Risk Factors

Journal

Publisher

MDPI
DOI: 10.3390/ijns8040058

Keywords

cystic fibrosis; CF; newborn screening; missed cases; immunoreactive trypsinogen; IRT

Funding

  1. National Newborn Screening and Genetics Resource Center
  2. Legacy of Angels Foundation

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This survey aimed to identify factors associated with missed cystic fibrosis cases due to low immunoreactive trypsinogen (IRT) levels below program cutoffs. Factors such as race, IRT cutoff values, genotypes, and birth and feeding factors were found to be associated with missed CF cases. Lowering IRT cutoff values and addressing hospital and laboratory factors may help reduce missed CF cases.
Testing immunoreactive trypsinogen (IRT) is the first step in cystic fibrosis (CF) newborn screening. While high IRT is associated with CF, some cases are missed. This survey aimed to find factors associated with missed CF cases due to IRT levels below program cutoffs. Twenty-nine states responded to a U.S-wide survey and 13 supplied program-related data for low IRT false screen negative cases (CFFN) and CF true screen positive cases (CFTP) for analysis. Rates of missed CF cases and odds ratios were derived for each factor in CFFNs, and two CFFN subgroups, IRT above (high) and below (low) the CFFN median (39 ng/mL) compared to CFTPs for this entire sample set. Factors associated with high CFFN subgroup were Black race, higher IRT cutoff, fixed IRT cutoff, genotypes without two known CF-causing variants, and meconium ileus. Factors associated with low CFFN subgroup were older age at specimen collection, Saturday birth, hotter season of newborn dried blood spot collection, maximum >= 3 days laboratories could be closed, preterm birth, and formula feeding newborns. Lowering IRT cutoffs may reduce high IRT CFFNs. Addressing hospital and laboratory factors (like training staff in collection of blood spots, using insulated containers during transport and reducing consecutive days screening laboratories are closed) may reduce low IRT CFFNs.

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