Journal
BIOENGINEERING-BASEL
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/bioengineering10010005
Keywords
zebrafish; optical coherence tomography; angiography; polarization-sensitive; multi-modal imaging pre-clinical; biomedical research
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The zebrafish is an established vertebrate model in biomedical research, especially for high-throughput studies. Recently, optical coherence tomography (OCT) has been widely used in zebrafish research. This review article summarizes the relevant literature and provides an outlook for this emerging field.
The zebrafish is an established vertebrae model in the field of biomedical research. With its small size, rapid maturation time and semi-transparency at early development stages, it has proven to be an important animal model, especially for high-throughput studies. Three-dimensional, high-resolution, non-destructive and label-free imaging techniques are perfectly suited to investigate these animals over various development stages. Optical coherence tomography (OCT) is an interferometric-based optical imaging technique that has revolutionized the diagnostic possibilities in the field of ophthalmology and has proven to be a powerful tool for many microscopic applications. Recently, OCT found its way into state-of-the-art zebrafish-based research. This review article gives an overview and a discussion of the relevant literature and an outlook for this emerging field.
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