Mechanical Properties and Biocompatibility of 3D Printing Acrylic Material with Bioactive Components

The aim of this study was to create a 3D printing material with bioactive properties that potentially could be used for a transparent removable orthodontic appliance. Materials and methods. To acrylic monomers, four bioactive glasses at 10% concentration were added, which release Ca, P, Si and F ions. The materials were printed on a 3D printer and tested for flexural strength (24 h and 30 days), sorption and solubility (7 days), ion release to artificial saliva pH = 4 and 7 (42 days) and cytotoxicity in the human fibroblast model. The released ions were determined by plasma spectrometry (Ca, P and Si ions) and ion-selective electrode (F measurement)s. Results: The material obtained released Ca2+ and PO43- ions for a period of 42 days when using glass Biomin C at pH 4. The flexural strength depended on the direction in which the sample was printed relative to the 3D printer platform. Vertically printed samples had a resistance greater than 20%. The 10% Biomin C samples post-cured for 30 min with light had a survival rate of the cells after 72 h of 85%.Conclusions. Material for 3D printing with bioactive glass in its composition, which releases ions, can be used in the production of orthodontic aligners.

Automated summary

The aim of this study was to develop a 3D printing material with bioactive properties for producing transparent removable orthodontic appliances. By adding four bioactive glasses at 10% concentration to acrylic monomers, ions such as Ca, P, Si, and F were released. The printed materials were tested for various properties including flexural strength, sorption and solubility, ion release, and cytotoxicity. The results showed that the material released Ca2+ and PO43- ions for 42 days and had good flexural strength in certain orientations. Furthermore, cell survival rate was high after exposure to the material.