Journal
CELLULAR IMMUNOLOGY
Volume 294, Issue 2, Pages 80-83Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2014.12.002
Keywords
Gender; Autoimmunity; TLR7; T-bet; IFNgamma; ABCs
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Funding
- USPHS Grant [AI-18785]
- T32 training grant [AI074491]
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The majority of autoimmune diseases have a strong gender bias, affecting mostly females. Gender-specific factors like sex-hormones, the presence or absence of a second X chromosome, and gender-specific gut microbiota may contribute to this bias. In this review we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and interferon gamma (IFN gamma) in the development of autoimmunity. We will also review recent data indicating how these factors may affect an immune response in a gender-dependent manner. (C) 2014 Elsevier Inc. All rights reserved.
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