Journal
JOURNAL OF SURGICAL RESEARCH
Volume 202, Issue 1, Pages 225-234Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2015.12.008
Keywords
IAP; Sepsis; NEC; IBD; Metabolic syndrome; Intestinal microbiome; Bacterial translocation
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Funding
- NCATS NIH HHS [UL1 TR000055] Funding Source: Medline
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Over the past few years, there is increasing evidence implicating a novel role for Intestinal Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders. IAP is an endogenous protein expressed by the intestinal epithelium that is believed to play a vital role in maintaining gut homeostasis. Loss of IAP expression or function is associated with increased intestinal inflammation, dysbiosis, bacterial translocation and subsequently systemic inflammation. As these events are a cornerstone of the pathophysiology of many diseases relevant to surgeons, we sought to review recent research in both animal and humans on IAP's physiologic function, mechanisms of action and current research in specific surgical diseases. (C) 2016 Elsevier Inc. All rights reserved.
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