Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 8, Pages 1517-1536Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-014-1813-y
Keywords
Megakaryocytes (Mk); Bone marrow (BM); Vascular niche; Endothelial cells; Osteoblasts; Fibrosis; Myeloproliferative diseases; Thrombopoietin (Thpo); Extracellular matrices (ECMs)
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Funding
- Cariplo Foundation [2010-0807]
- Italian Ministry of Health [RF-2009-1550218]
- Italian Ministry of University and Research FIRB [RBFR1299KO]
- Associazione Italiana per la Ricerca sul Cancro (AIRC, Milano) Special Program Molecular Clinical Oncology 5 x 1000''
- US National Institutes of Health [EB016041-01]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB016041] Funding Source: NIH RePORTER
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Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday production and release of millions of platelets into the bloodstream. Since the discovery and cloning, in 1994, of their principal humoral factor, thrombopoietin, and its receptor c-Mpl, many efforts have been directed to define the mechanisms underlying an efficient platelet production. However, more recently different studies have pointed out new roles for megakaryocytes as regulators of bone marrow homeostasis and physiology. In this review we discuss the interaction and the reciprocal regulation of megakaryocytes with the different cellular and extracellular components of the bone marrow environment. Finally, we provide evidence that these processes may concur to the reconstitution of the bone marrow environment after injury and their deregulation may lead to the development of a series of inherited or acquired pathologies.
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