4.7 Review

Role of connexins and pannexins in cardiovascular physiology

Journal

CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 15, Pages 2779-2792

Publisher

SPRINGER BASEL AG
DOI: 10.1007/s00018-015-1959-2

Keywords

Connexins; Pannexins; Gap junction channel; Hemichannel; Cardiovascular; Physiology

Funding

  1. Swiss National Science Foundation [310030_143343, CRSII3_141811]

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Connexins and pannexins form connexons, pannexons and membrane channels, which are critically involved in many aspects of cardiovascular physiology. For that reason, a vast number of studies have addressed the role of connexins and pannexins in the arterial and venous systems as well as in the heart. Moreover, a role for connexins in lymphatics has recently also been suggested. This review provides an overview of the current knowledge regarding the involvement of connexins and pannexins in cardiovascular physiology.

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