Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 21, Pages 4157-4172Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2028-6
Keywords
Wnt signaling; Neural stem cells; Beta-catenin; AP-1 family transcription factors
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Funding
- Spanish Ministry of Education and Science [SAF2011-30494, SAF2014-51966-R]
- Government of the Autonomous Community of the Basque Country Department of Education, Industry, Tourism and Trade
- Government of the Autonomous Community of the Basque Country Department of Innovation Technology
- Garfield Weston Foundation
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The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the development of a large part of the mouse brain over 25 years ago. We have since learned that Wnt family secreted glycolipoproteins, of which there are nineteen, which activate a diverse network of signals that are particularly important during embryonic development and tissue regeneration. Wnt signals in the developing and adult brain can drive neural stem cell self-renewal, expansion, asymmetric cell division, maturation and differentiation. The molecular events taking place after a Wnt binds to its cell-surface receptors are complex and, at times, controversial. A deeper understanding of these events is anticipated to lead to improvements in the treatment of neurodegenerative diseases and stem cell-based replacement therapies. Here, we review the roles played by Wnts in neural stem cells in the developing mouse brain, at neurogenic sites of the adult mouse and in neural stem cell culture models.
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