Related references
Note: Only part of the references are listed.Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase
Yanping Xu et al.
CANCER RESEARCH (2014)
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
Bernadette M. M. Zwaans et al.
DISEASE MODELS & MECHANISMS (2014)
Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity
Takeshi Tsusaka et al.
GENES TO CELLS (2014)
Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal
Tingting Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
SIRT4 Protein Suppresses Tumor Formation in Genetic Models of Myc-induced B Cell Lymphoma
Seung Min Jeong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
Takumi Mikawa et al.
JOURNAL OF CELL BIOLOGY (2014)
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
Yasuhito Onodera et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Reciprocal Regulation of HIF-1 alpha and LincRNA-p21 Modulates the Warburg Effect
Fan Yang et al.
MOLECULAR CELL (2014)
PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells
Yuhui Jiang et al.
MOLECULAR CELL (2014)
Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
D. Gitenay et al.
CELL DEATH & DISEASE (2014)
Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1
Takashi Baba et al.
NATURE COMMUNICATIONS (2014)
Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer
Di Zhao et al.
CANCER CELL (2013)
AMPK: A Contextual Oncogene or Tumor Suppressor?
Jiyong Liang et al.
CANCER RESEARCH (2013)
AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Marcos Rios et al.
CANCER RESEARCH (2013)
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
William J. Israelsen et al.
CELL (2013)
Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
Akiko Satoh et al.
CELL METABOLISM (2013)
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Brandon Faubert et al.
CELL METABOLISM (2013)
HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase
Torstein Baade Ro et al.
EXPERIMENTAL HEMATOLOGY (2013)
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
Maimon E. Hubbi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization
Lei Lv et al.
MOLECULAR CELL (2013)
AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
Ning Wu et al.
MOLECULAR CELL (2013)
Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice
Junji Okuda et al.
PLOS ONE (2013)
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
Taro Hitosugi et al.
NATURE COMMUNICATIONS (2013)
SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease
Jiyung Shin et al.
CELL REPORTS (2013)
Cancer cell metabolism: implications for therapeutic targets
Miran Jang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2013)
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis
Hsieh-Cheng Chen et al.
ANNALS OF SURGICAL ONCOLOGY (2012)
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level
Oh-Hyung Kwon et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
Taro Hitosugi et al.
CANCER CELL (2012)
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
Weiwei Yang et al.
CELL (2012)
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Carlos Sebastian et al.
CELL (2012)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Haoqiang Ying et al.
CELL (2012)
Anticancer Agents That Counteract Tumor Glycolysis
Carlotta Granchi et al.
CHEMMEDCHEM (2012)
Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
William C. Hallows et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
Xueliang Gao et al.
MOLECULAR CELL (2012)
The sirtuin SIRT6 regulates lifespan in male mice
Yariv Kanfi et al.
NATURE (2012)
ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2
Nanduri R. Prabhakar et al.
PHYSIOLOGICAL REVIEWS (2012)
SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions
Kirstie E. Keller et al.
SCIENCE (2012)
PPARγ contributes to PKM2 and HK2 expression in fatty liver
Ganna Panasyuk et al.
NATURE COMMUNICATIONS (2012)
Glyceraldehyde-3-Phosphate Dehydrogenase: A Promising Target for Molecular Therapy in Hepatocellular Carcinoma
Shanmugasundaram Ganapathy-Kanniappan et al.
ONCOTARGET (2012)
Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease
Gerald W. Hart et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity
Hyun-Seok Kim et al.
CANCER CELL (2011)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
Lydia W. S. Finley et al.
CANCER CELL (2011)
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Weibo Luo et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia
Hao Geng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle
Katarzyna Banaszak et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
mTOR links oncogenic signaling to tumor cell metabolism
Jessica L. Yecies et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2011)
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
Lei Lv et al.
MOLECULAR CELL (2011)
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
Weiwei Yang et al.
NATURE (2011)
Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression
Ji-Won Jung et al.
PLOS ONE (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells
Marzia B. Gariboldi et al.
BIOCHEMICAL PHARMACOLOGY (2010)
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim et al.
CANCER CELL (2010)
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
Lei Zhong et al.
CELL (2010)
Diabetes and Cancer A consensus report
Edward Giovannucci et al.
DIABETES CARE (2010)
Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation
Kelly M. Kennedy et al.
FUTURE ONCOLOGY (2010)
The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
James J. Manfredi
GENES & DEVELOPMENT (2010)
Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
Randa Tao et al.
MOLECULAR CELL (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Ji-Hong Lim et al.
MOLECULAR CELL (2010)
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David et al.
NATURE (2010)
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
Cynthia V. Clower et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
Matthew G. Vander Heiden et al.
SCIENCE (2010)
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
Zhaohui Feng et al.
TRENDS IN CELL BIOLOGY (2010)
Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma
Eun Jung Cha et al.
CLINICAL CANCER RESEARCH (2009)
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
Carles Canto et al.
CURRENT OPINION IN LIPIDOLOGY (2009)
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
Jian Yuan et al.
JOURNAL OF CELL BIOLOGY (2009)
Common corruption of the mTOR signaling network in human tumors
S Menon et al.
ONCOGENE (2009)
P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine
J. Sun et al.
ONCOGENE (2009)
PAK signaling in oncogenesis
P. R. Molli et al.
ONCOGENE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Taro Hitosugi et al.
SCIENCE SIGNALING (2009)
Hexokinase-2 bound to mitochondria: Cancer's stygian link to the Warburg effect and a pivotal target for effective therapy
Saroj P. Mathupala et al.
SEMINARS IN CANCER BIOLOGY (2009)
Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma
Hiroaki Itamochi et al.
CANCER SCIENCE (2008)
Roles of p53, Myc and HIF-1 in Regulating Glycolysis - the Seventh Hallmark of Cancer
S. J. Yeung et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation
David M. Burns et al.
GENES & DEVELOPMENT (2008)
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription
Jungwoon Lee et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
P53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
Keiko Kawauchi et al.
NATURE CELL BIOLOGY (2008)
Hypoxia up-regulates hypoxia-inducible factor-1α transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells
Rachida S. BelAiba et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
HIF-2α specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites
A. Le Bras et al.
ONCOGENE (2007)
The role of hypoxia-inducible factors in cancer
M. A. Maynard et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
Hiroshi Kondoh et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
S. P. Mathupala et al.
ONCOGENE (2006)
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
Karim Bensaad et al.
CELL (2006)
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition -: The role of HIF-1α, HIF-2α, and other pathways
Gareth P. Elvidge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
HIF-2α regulates Oct-4:: effects of hypoxia on stem cell function, embryonic development, and tumor growth
KL Covello et al.
GENES & DEVELOPMENT (2006)
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1α
DA Chan et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
JS Isaacs et al.
CANCER CELL (2005)
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
RG Jones et al.
MOLECULAR CELL (2005)
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
ML Macheda et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MA Selak et al.
CANCER CELL (2005)
JunD reduces tumor angiogenesis by protecting cells from oxidative stress
D Gerald et al.
CELL (2004)
Evaluation of MYC E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
JW Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
B Altenberg et al.
GENOMICS (2004)
Why do cancers have high aerobic glycolysis?
RA Gatenby et al.
NATURE REVIEWS CANCER (2004)
Akt stimulates aerobic glycolysis in cancer cells
RL Elstrom et al.
CANCER RESEARCH (2004)
The cellular fate of glucose and its relevance in type 2 diabetes
C Bouché et al.
ENDOCRINE REVIEWS (2004)
HIF-1α induces cell cycle arrest by functionally counteracting Myc
M Koshiji et al.
EMBO JOURNAL (2004)
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
S Parrinello et al.
NATURE CELL BIOLOGY (2003)
AMP-activated protein kinase and muscle glucose uptake
N Musi et al.
ACTA PHYSIOLOGICA SCANDINAVICA (2003)
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
H Sano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cooperative interaction of hypoxia-inducible factor-2α (HIF-2α) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)
G Elvert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase
T Shalom-Barak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
R Fukuda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
HS Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
T Kamura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Accelerated publication -: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
RC Osthus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
S Imai et al.
NATURE (2000)
Share Paper
