Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 10, Pages 1881-1892Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-1840-3
Keywords
Warburg effect; Cancer; HIF-1; Sirtuin; Myc; PGAM
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Funding
- Grants-in-Aid for Scientific Research [26310103, 25670350] Funding Source: KAKEN
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Enhanced glycolysis in cancer, called the Warburg effect, is a well-known feature of cancer metabolism. Recent advances revealed that the Warburg effect is coupled to many other cancer properties, including adaptation to hypoxia and low nutrients, immortalisation, resistance to oxidative stress and apoptotic stimuli, and elevated biomass synthesis. These linkages are mediated by various oncogenic molecules and signals, such as c-Myc, p53, and the insulin/Ras pathway. Furthermore, several regulators of glycolysis have been recently identified as oncogene candidates, including the hypoxia-inducible factor pathway, sirtuins, adenosine monophosphate-activated kinase, glycolytic pyruvate kinase M2, phosphoglycerate mutase, and oncometabolites. The interplay between glycolysis and oncogenic events will be the focus of this review.
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