Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 18, Pages 3441-3455Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-1935-x
Keywords
SNX-BAR; Retromer; Fission; Endosome; Recycling; Retrograde; Sorting
Categories
Funding
- United States National Institute of Health [GM060221, GM095766]
- Postdoctoral Fellowship from the American Heart Association [13POST16930024]
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Sorting of macromolecules within the endosomal system is vital for physiological control of nutrient homeostasis, cell motility, and proteostasis. Trafficking routes that export macromolecules from the endosome via vesicle and tubule transport carriers constitute plasma membrane recycling and retrograde endosome-to-Golgi pathways. Proteins of the sorting nexin family have been discovered to function at nearly every step of endosomal transport carrier biogenesis and it is becoming increasingly clear that they form the core machineries of cargo-specific transport pathways that are closely integrated with cellular physiology. Here, we summarize recent progress in elucidating the pathways that mediate the biogenesis of endosome-derived transport carriers.
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