Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 6, Pages 1195-1207Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2116-7
Keywords
Cadherin; Cdc42; Cortical actin; JAM-A; Junctional adhesion molecules; LGN; MDCK; PtdIns(3,4,5)P3
Categories
Funding
- Deutsche Forschungsgemeinschaft [EB 160/4-1, EB 160/4-2]
- Medical Faculty of the University Munster [IZKF Eb2/028/09, Eb2/020/14]
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Polarized epithelial cells align the mitotic spindle in the plane of the sheet to maintain tissue integrity and to prevent malignant transformation. The orientation of the spindle apparatus is regulated by the immobilization of the astral microtubules at the lateral cortex and depends on the precise localization of the dynein-dynactin motor protein complex which captures microtubule plus ends and generates pulling forces towards the centrosomes. Recent developments indicate that signals derived from intercellular junctions are required for the stable interaction of the dynein-dynactin complex with the cortex. Here, we review the molecular mechanisms that regulate planar spindle orientation in polarized epithelial cells and we illustrate how different cell adhesion molecules through distinct and non-overlapping mechanisms instruct the cells to align the mitotic spindle in the plane of the sheet.
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