Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 22, Pages 4327-4340Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2008-x
Keywords
Galectins; Cellular stress responses; Hypoxia; Cancer; Apoptosis; Cell survival; Transcription factors; miRNA
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Funding
- Western Strategic Support for NSERC Success Seed Grant (Western University, London, Ontario)
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Galectins, a family of soluble beta-galactoside-binding proteins, serve as mediators of fundamental biological processes, such as cell growth, differentiation, adhesion, migration, survival, and death. The purpose of this review is to summarize the current knowledge regarding the ways in which the expression of individual galectins differs in normal and transformed human cells exposed to various stimuli mimicking physiological and pathological microenvironmental stress conditions. A conceptual point is being made and grounded that the modulation of galectin expression profiles is a key aspect of cellular stress responses. Moreover, this modulation might be precisely regulated at transcriptional and post-transcriptional levels in the context of non-overlapping transcription factors and miRNAs specific to galectins.
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