Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 5, Pages 1039-1050Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2108-7
Keywords
CML; AML; LSC; Wnt; Hox; Hh; Alox5; miRNA; Microenvironment
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Funding
- State Key Laboratory of Biotherapy, West China Hospital
- Sichuan University
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Leukemia stem cells (LSCs) are a subpopulation cells at the apex of hierarchies in leukemia cells and responsible for disease continuous propagation. In this article, we discuss some cellular and molecular components, which are critical for LSC survival. These components include intrinsic signaling pathways and extrinsic microenvironments. The intrinsic signaling pathways to be discussed include Wnt/beta-catenin signaling, Hox genes, Hh pathway, Alox5, and some miRNAs, which have been shown to play important roles in regulating LSC survival and proliferation. The extrinsic components to be discussed include selectins, CXCL12/CXCR4, and CD44, which involve in LSC homing, survival, and proliferation by affecting bone marrow microenvironment. Potential strategies for eradicating LSCs will also discuss.
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