Journal
ADVANCED MATERIALS
Volume 27, Issue 34, Pages 5002-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502767
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Funding
- NSERC
- CIHR
- NSERC Vanier scholarship
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Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long-lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injection, allowing for ease of use and storage. Controlled release of two relevant protein therapeutics and biocompatibility of the hydrogel are demonstrated.
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