Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 23, Pages 4577-4592Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2023-y
Keywords
Histone methylation; Histone methyltransferase; Histone demethylase; Oncogenic signaling; Tumor suppressor pathway
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Funding
- NIH [R01 GM095659, R01 CA157919]
- Center for Cancer Epigenetics at The University of Texas MD Anderson Cancer Center
- Cancer Prevention and Research Institute of Texas [RP110183]
- Odyssey Program at MD Anderson Cancer Center
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Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-kappa B, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/beta-catenin, p53, and ER alpha.
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