Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 6, Pages 1119-1130Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2090-0
Keywords
Cell migration; Cell polarity; Cell adhesion; Cadherin; Rho; Rac
Categories
Funding
- MRC [M010465, J000655]
- BBSRC [M008517]
- Wellcome Trust
- BBSRC
- Biotechnology and Biological Sciences Research Council [BB/M008517/1, 1052617] Funding Source: researchfish
- Medical Research Council [MR/M010465/1] Funding Source: researchfish
- BBSRC [BB/M008517/1] Funding Source: UKRI
- MRC [MR/M010465/1] Funding Source: UKRI
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Contact inhibition of locomotion (CIL) is a complex process, whereby cells undergoing a collision with another cell cease their migration towards the colliding cell. CIL has been identified in numerous cells during development including embryonic fibroblasts, neural crest cells and haemocytes and is the driving force behind a range of phenomenon including collective cell migration and dispersion. The loss of normal CIL behaviour towards healthy tissue has long been implicated in the invasion of cancer cells. CIL is a multi-step process that is driven by the tight coordination of molecular machinery. In this review, we shall breakdown CIL into distinct steps and highlight the key molecular mechanisms and components that are involved in driving each step of this process.
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