Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 12, Issue 5, Pages 525-532Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2015.12
Keywords
autoimmune; Foxp3; instability; pathogenic; Treg cell
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Funding
- National Key Basic Research and Development 973 Program of China [2012CB917102]
- National Natural Science Foundation of China [31270959]
- China Postdoctoral Science Foundation [2011M500422]
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Foxp3(+) regulatory T (Treg) cells are considered a sub-lineage of CD4(+) T cells that are protective against autoimmunity due to their essential roles in maintaining immune homeostasis and self-tolerance. However, Treg cells are unstable in vivo in terms of lineage specialization and suppressive function. These unstable Treg cells play roles in the pathogenesis of diseases, which cause safety concerns regarding human Treg cell therapy. In this review, we highlight recent findings that demonstrate the pathogenic conversion of Treg cells in different disease models.
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