Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 12, Issue 5, Pages 553-557Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cmi.2014.133
Keywords
atRA; autoimmune diseases; Foxp3; Treg cells
Categories
Funding
- NIH [AR059103, AI084359]
- National Natural Science Foundation of China [81274161, 81001307, 81370433, 81170084]
- Zhejiang Provincial Natural Science Foundation of China [Y2090918]
- Health Bureau of Zhejiang Province [2012RCA046]
Ask authors/readers for more resources
Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. Foxp3(+) Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available