Journal
CURRENT DIABETES REVIEWS
Volume 19, Issue 8, Pages -Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573399819666230102141154
Keywords
Amyloid beta proteins; antihyperglycaemic agent; cognitive impairment; dysmetabolism; lipid dysmetabolism; tau phosphorylation
Categories
Ask authors/readers for more resources
In recent years, there has been increasing evidence linking dysmetabolism, including diabetes mellitus and metabolic syndrome, to the development of Alzheimer's disease (AD). Metabolic hormones like ghrelin, leptin, insulin, and insulin-like growth factor (IGF)-1 have been reported to play key roles in neuronal injury and loss in AD. This review examines the current scientific evidence on the role of dysmetabolism in AD and its impact on disease progression and the development of novel therapies.
Over the last century, there has been a gradual but sustained increase in life expectancy globally. A consequence of increased life expectancy is an associated rise in the prevalence of age-related chronic debilitating neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease, Huntington's disease, and multiple sclerosis. These disorders, which are generally characterised by the loss of motor/sensory neurons and cognitive decline, have continued to confound researchers who are working tirelessly to define their pathogenetic mechanisms and develop effective therapies. In the last few years, there has been increasing evidence of the existence of a relationship between energy metabolism and neurodegeneration, with reports that type 2 diabetes mellitus increases the risk of AD. Evidence from preclinical and epidemiologic studies has associated dysmetabolism and dysmetabolic syndromes with the development of neurodegenerative changes. More recently, diabetes mellitus and energy dysmetabolism have been linked to the aetiopathogenesis of AD. Moreover, metabolic hormones, including ghrelin, leptin, insulin, and insulin-like growth factor (IGF)-1, have been reported to play key roles in the regulation of neuronal injury and loss in neurodegenerative diseases like AD. In this narrative review, we examine the current scientific evidence regarding the role of dysmetabolism (including diabetes mellitus and metabolic syndrome) in AD and how it impacts disease progression and the development of novel therapies in AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available