3.9 Article

Imbalance in the ratio between mineralocorticoid and glucocorticoid receptors and neurodegeneration in the dentate gyrus of aged dogs

Related references

Note: Only part of the references are listed.
Article Veterinary Sciences

Novel Diagnostic Tools for Identifying Cognitive Impairment in Dogs: Behavior, Biomarkers, and Pathology

Zuzana Vikartovska et al.

Summary: A comprehensive approach using CADES questionnaire, biochemical analyses and blood serum biomarkers can enable early diagnosis of canine cognitive dysfunction syndrome (CCDS) in senior dogs.

FRONTIERS IN VETERINARY SCIENCE (2021)

Review Cell Biology

Cellular Senescence in Adrenocortical Biology and Its Disorders

Xin Gao et al.

Summary: Cellular senescence, a physiological process associated with aging, plays a role in the pathogenesis of many age-related disorders. The adrenal cortex exhibits age-dependent features, with aldosterone and adrenal androgen levels decreasing while cortisol levels increasing with age. Various types of tumors in the adrenal cortex present different senescent phenotypes, impacting hormone production.

CELLS (2021)

Article Neurosciences

The Flow of Axonal Information Among Hippocampal Subregions: 1. Feed-Forward and Feedback Network Spatial Dynamics Underpinning Emergent Information Processing

Yash S. Vakilna et al.

Summary: Researchers reconstructed elements of the hippocampus in a novel device to monitor the directionality of axons between subregions. They found that information largely flows from the entorhinal cortex (EC) to the dentate gyrus (DG), with unexpected dynamics in the axonal connections between regions. The study revealed both constraints and broad emergent dynamics in the rich axonal spike dynamics within the hippocampal architecture.

FRONTIERS IN NEURAL CIRCUITS (2021)

Article Cell Biology

Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5

Jakob Hartmann et al.

Summary: The study highlights the critical role of FK506-binding protein 51 (FKBP5) in fine-tuning mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) balance in the hippocampus. Lack of MR decreases hippocampal Fkbp5 levels and dampens the stress-induced increase in glucocorticoid levels, providing insight into mechanisms of stress homeostasis.

CELL REPORTS (2021)

Review Neurosciences

Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

Thomas Hainmueller et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Article Behavioral Sciences

Age influences domestic dog cognitive performance independent of average breed lifespan

Marina M. Watowich et al.

ANIMAL COGNITION (2020)

Review Geriatrics & Gerontology

High Cortisol and the Risk of Dementia and Alzheimer's Disease: A Review of the Literature

Sami Ouanes et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Endocrinology & Metabolism

Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective

Anne-Sophie C. A. M. Koning et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2019)

Article Geriatrics & Gerontology

Cognitive Aging in Dogs

Durga Chapagain et al.

GERONTOLOGY (2018)

Review Endocrinology & Metabolism

Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation

E. R. de Kloet et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2018)

Review Behavioral Sciences

An analysis of dentate gyrus function (an update)

Raymond P. Kesner

BEHAVIOURAL BRAIN RESEARCH (2018)

Review Neurosciences

Central Role of Glucocorticoid Receptors in Alzheimer's Disease and Depression

Geoffrey Canet et al.

FRONTIERS IN NEUROSCIENCE (2018)

Review Clinical Neurology

Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging

Kathleen M. McAvoy et al.

NEUROTHERAPEUTICS (2017)

Article Anatomy & Morphology

Distinction of Neurons, Glia and Endothelial Cells in the Cerebral Cortex: An Algorithm Based on Cytological Features

Miguel A. Garcia-Cabezas et al.

FRONTIERS IN NEUROANATOMY (2016)

Article Neurosciences

Glucocorticoid-Related Molecular Signaling Pathways Regulating Hippocampal Neurogenesis

Christoph Anacker et al.

NEUROPSYCHOPHARMACOLOGY (2013)

Review Neurosciences

Stress, stress hormones, and adult neurogenesis

Timothy J. Schoenfeld et al.

EXPERIMENTAL NEUROLOGY (2012)

Article Behavioral Sciences

Selective lesions of the dentate gyrus produce disruptions in place learning for adjacent spatial locations

Andrea M. Morris et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2012)

Article Geriatrics & Gerontology

Neurobiology of the aging dog

Elizabeth Head

Article Veterinary Sciences

Comparison of Density and Morphology of Neuroblasts in the Dentate Gyrus among Variously Aged Dogs, German Shepherds

In Koo Hwang et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2009)

Article Geriatrics & Gerontology

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment

Christina T. Siwak-Tapp et al.

NEUROBIOLOGY OF AGING (2008)

Article Multidisciplinary Sciences

Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging

SA Small et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Urology & Nephrology

Specificity in mineralocorticoid versus glucocorticoid action

PJ Fuller et al.

KIDNEY INTERNATIONAL (2000)