Journal
CELL STRESS & CHAPERONES
Volume 20, Issue 3, Pages 537-543Publisher
SPRINGER
DOI: 10.1007/s12192-015-0578-z
Keywords
Rheumatoid arthritis; Heat shock protein 70; Disease activity; Diagnostic serummarker; HSPA1A
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Heat shock proteins (HSPs) have been repeatedly implicated in the pathogenesis of rheumatoid arthritis (RA). The authors aimed to study applicability of heat shock protein 70 (HSPA1A) serum levels as a diagnostic factor and a severity indicator in patients with RA and to quantify cut-off point that predicts status of RA with highest specificity. A total of 76 patients with RA and 36 healthy adults were studied in this case-control analysis. Patients had a higher HSPA1A level than the control group (0.78 +/- 0.13 vs. 0.12 +/- 0.02 ng/mL, p = 0.006), irrespective of presence of absence of rheumatoid factor or anti-citrullinated cyclic peptide. Next, diagnostic accuracy of the HSPA1A in diagnosis of RA was evaluated (area under curve 0.71; p < 0.05). HSPA1A predicted status of having RA in levels above 0.42 ng/mL with more than 90 % specificity. In addition to diagnostic value, HSPA1A can distinguish between high disease activity (1.66 +/- 0.75 ng/mL) and low (0.49 +/- 0.1 ng/mL), moderate (0.52 +/- 0.12 ng/mL), or remission phase (0.48 +/- 0.11 ng/mL). Moreover, patients in remission still had a higher HSPA1A level compared to normal subject (0.48 +/- 0.11 vs. 0.12 +/- 0.02 ng/mL, p < 0.05). Our results showed that serum HSPA1A could be implemented as a specific tool to facilitate diagnosis and monitoring disease activity in patients with rheumatoid arthritis.
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