Dataset of dual RNA-seq mapping in visceral leishmaniasis: Inquiry on parasite transcripts in human blood transcriptome upon Leishmania infantum infection

This dataset is related to the article Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Hu-man Blood Transcriptome Upon Leishmania infantum Infec-tion by S.R. Maruyama, C.A. Fuzo, A .E.R. Oliveira, L.A . Roge-rio, N.T. Takamiya, G. Pessenda, E.V. de Melo, A.M. da Silva, A.R. Jesus, V. Carregaro, H.I. Nakaya, R.P. Almeida and J.S. da Silva. Frontiers in Immunology, 2022. Through the reuse of raw sequencing data, we generated original dataset by per-forming a dual RNA-seq mapping procedure to survey the parasite transcripts found in RNA-seq samples from blood of visceral leishmaniasis patients. Diseased patients with active infection displayed the highest number of reads mapped to L. infantum genome. Even after six months later of the treatment, when the patients were considered cured, parasite reads were still detected. Parasite reads were also detected in asymptomatic individuals. The original dual RNA-seq alignment read count data provided here can be further explored to evaluate either host or parasite transcripts. (C) 2022 The Author(s). Published by Elsevier Inc.

Automated summary

This dataset is related to the article "Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania infantum Infection" by S.R. Maruyama, C.A. Fuzo, A.E.R. Oliveira, L.A. Rogerio, N.T. Takamiya, G. Pessenda, E.V. de Melo, A.M. da Silva, A.R. Jesus, V. Carregaro, H.I. Nakaya, R.P. Almeida and J.S. da Silva. Frontiers in Immunology, 2022. The dataset was generated by reusing raw sequencing data and performing a dual RNA-seq mapping procedure to analyze parasite transcripts in blood samples from visceral leishmaniasis patients. The highest number of reads mapped to the L. infantum genome was observed in diseased patients with active infection, and parasite reads were still detected even after six months of treatment and in asymptomatic individuals. This original dataset can be further used to study host or parasite transcripts.