4.5 Review

The role of macrophages in reproductive-related diseases

Related references

Note: Only part of the references are listed.
Article Obstetrics & Gynecology

The extracellular vesicular pseudogene LGMNP1 induces M2-like macrophage polarization by upregulating LGMN and serves as a novel promising predictive biomarker for ovarian endometriosis recurrence

S. G. Sun et al.

Summary: EV-LGMNP1, abundant in Ecto-ESCs and serum from ovarian EMs patients, can induce M2 macrophage polarization by upregulating LGMN expression, making it a promising biomarker for predicting ovarian EMs recurrence.

HUMAN REPRODUCTION (2022)

Article Oncology

B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

Taito Miyamoto et al.

Summary: This study explored the immunosuppressive effect of B7-H3 in high-grade serous ovarian cancer (HGSOC) and found that it contributes to immune suppression and tumor progression through the CCL2-CCR2-M2 macrophage axis. These findings provide new insights into the immunologic tumor microenvironment and could aid the development of new therapeutic approaches.

CANCER IMMUNOLOGY RESEARCH (2022)

Article Cell Biology

Chemerin promotes the pathogenesis of preeclampsia by activating CMKLR1/p-Akt/CEBPalpha axis and inducing M1 macrophage polarization

Zhi-Song Ji et al.

Summary: The chemerin signaling pathway involving CMKLR1/Akt/CEBP alpha axis plays a crucial role in regulating macrophage polarization and mediating the pathogenic effects of chemerin on preeclampsia. Targeting chemerin signaling may offer potential benefits for the prevention and treatment of preeclampsia.

CELL BIOLOGY AND TOXICOLOGY (2022)

Article Immunology

Clinical outcome of intrauterine administration of peripheral mononuclear cells or human chorionic gonadotropin in unexplained implantation failure

Jie Mei et al.

Summary: Intrauterine administration of hCG-activated PBMC and hCG did not improve clinical outcomes for both RIF and non-RIF patients in FET cycles with previous implantation failures.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2022)

Article Medicine, Research & Experimental

Endometriosis derived exosomal miR-301a-3p mediates macrophage polarization via regulating PTEN-PI3K axis

Ye Huang et al.

Summary: This study found that exosomes derived from endometriosis and miR-301a-3p can affect the polarization of macrophages. Exosomes mediate the polarization of macrophages to M2 macrophages by regulating the PTEN-PI3K axis.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Biochemistry & Molecular Biology

The Roles of Extracellular Vesicles and Organoid Models in Female Reproductive Physiology

Riley E. Thompson et al.

Summary: This article reviews and compares organoid culture systems with other in vitro cell culture models, focusing on the role of extracellular vesicle interactions. The critical role of extracellular vesicles in intercellular communication in physiological processes, including reproduction, is well-documented. Three-dimensional organoid culture systems provide a powerful approach to study the role of extracellular vesicles in normal and pathological conditions of reproductive organs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Developmental Biology

Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis

Jing Li et al.

Summary: Peritoneal macrophages play a significant role in the progression of endometriosis. Targeting CD47 can improve the phagocytosis of macrophages and induce apoptosis of ectopic endometrial stromal cells, suggesting that immunotherapy based on the CD47-SIRP alpha signaling pathway has potential in treating endometriosis.

MOLECULAR HUMAN REPRODUCTION (2022)

Article Immunology

Single-cell Raman trapping analysis revealed immunometabolism changes in peritoneal fluid in endometriosis

Chunyan Deng et al.

Summary: This study investigated the phenotypic and immunometabolism profiling of peritoneal fluid cells in endometriosis patients, revealing differences in cell percentages and intracellular changes compared to control groups. It also identified specific biological molecules associated with immune dysfunction in endometriosis, offering new insights into disease pathology and potential therapeutic targets.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2022)

Article Obstetrics & Gynecology

Endometrial HLA-F expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients

Henrieta Papuchova et al.

Summary: The study found that HLA-F protein is expressed in mid-secretory endometrium and its expression levels are influenced by HLA-F gene polymorphisms. HLA-F is correlated with immune cell infiltration and plasma progesterone concentrations. However, women with recurrent implantation failure show differences in HLA-F protein levels compared to women undergoing their first IVF treatment.

HUMAN REPRODUCTION (2022)

Article Obstetrics & Gynecology

Effect of theIDOGene on Pregnancy in Mice with Recurrent Pregnancy Loss

Hui Cheng et al.

Summary: The study showed that the IDO gene can reduce embryo absorption rate and improve pregnancy outcome in an RPL mouse model by upregulating Tregs and reducing inflammatory response.

REPRODUCTIVE SCIENCES (2021)

Article Endocrinology & Metabolism

The abnormal expression of kisspeptin regulates pro-inflammatory cytokines, cell viability and apoptosis of macrophages in hyperandrogenism induced by testosterone

Xiao Li et al.

Summary: The study demonstrates that kisspeptin plays a role in regulating the expression of pro-inflammatory cytokines and apoptosis induced by hyperandrogenism, suggesting that kisspeptin inactivation confers resistance to hyperandrogenism by inhibiting pro-inflammatory cytokines expressions and apoptosis.

GYNECOLOGICAL ENDOCRINOLOGY (2021)

Article Immunology

Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells

Jake R. Thomas et al.

Summary: Hofbauer cells are an important immune cell population found in the placenta, involved in placental angiogenesis and remodeling. Additionally, there is another population of maternal macrophages in the placenta that aid in surface repair.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

MIF-mediated NF-KB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats

Zhenlin He et al.

Summary: In rats with PCOS, testosterone increased levels of MIF and LH while inhibiting FSH levels; MIF antibody could alleviate PCOS progression to a certain extent. Testosterone also promoted the expression of inflammatory cytokines, which was reversed by the MIF antibody. This study suggests that increased MIF levels activate the NF-κB pathway in ovaries, leading to inflammation and relevant inflammatory indicators in PCOS pathogenesis.

CYTOKINE (2021)

Article Obstetrics & Gynecology

Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein L-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage

Fan Hao et al.

Summary: Elevated levels of PRMT3 and ADMA inhibit NO formation in the decidua, impairing trophoblast cell function at the maternal-foetal interface. PRMT3 expression was significantly up-regulated in macrophages of decidua from RM patients, but not in natural killer cells or stromal cells. The inhibition of PRMT3 leads to decreased ADMA accumulation and increased NO concentration in macrophages, suggesting a potential therapeutic target for RM.

HUMAN REPRODUCTION (2021)

Article Multidisciplinary Sciences

CD206+macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model

Yosuke Ono et al.

Summary: The study demonstrates that CD206+ MΦ promotes the formation of endometriotic-like lesions by inducing angiogenesis around the lesions. Depletion of CD206+ MΦ significantly reduces the total weight of lesions and angiogenesis.

SCIENTIFIC REPORTS (2021)

Article Immunology

Circadian rhythm-associated Rev-erbα modulates polarization of decidual macrophage via the PI3K/Akt signaling pathway

Liyuan Cui et al.

Summary: The study reveals that Rev-erb alpha may play a crucial role in macrophage polarization. Rev-erb alpha knockdown promoted M1 polarization while pharmacological activation induced M2-like polarization in decidual macrophages. These findings suggest a potential therapeutic target for pregnancy complications related to abnormal macrophage polarization.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis

Katja Eubler et al.

Summary: The study revealed that TRPV2 cation channel in mouse testis is mainly expressed in certain macrophages, with no significant increase in old mice. In transgenic mice with infertility-related sterile inflammation, TRPV2 expression levels significantly increase with age, along with macrophage markers and inflammation factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis

Yosuke Ono et al.

Summary: This study found that the concentration of S1P in the peritoneal fluid may be associated with endometriosis during both menstrual and non-menstrual phases. Experimental results suggest that S1P may play an important role in the formation and development of endometriosis lesions.

BIOMEDICINES (2021)

Article Immunology

Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

Liyuan Cui et al.

Summary: This study demonstrated that pharmacological activation of Rev-erb alpha using SR9009 could reduce inflammation-induced M1 polarization of macrophages, protect pregnancy, and offer a potential therapeutic strategy for inflammation-induced miscarriage.

BMC IMMUNOLOGY (2021)

Article Oncology

Salvianolic acid B improves autophagic dysfunction and decreases the apoptosis of cholesterol crystal-induced macrophages via inhibiting the Akt/mTOR signaling pathway

Mengqi Sun et al.

Summary: The study demonstrated that Sal B improved autophagic dysfunction and reduced apoptosis of CHC-induced macrophages by inhibiting the Akt/mTOR signaling pathway.

MOLECULAR MEDICINE REPORTS (2021)

Article Biochemistry & Molecular Biology

Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm

Mayuko Hashimoto et al.

Summary: The study demonstrates the distinct role of the deubiquitinating enzyme USP2 in organ-specific macrophages that directly affect sperm function. Knockout of Usp2 in testicular macrophages led to reduced sperm motility, capacitation, and hyperactivation, as well as decreased levels of intracellular pH, calcium influx, and mitochondrial membrane potential. Administration of GM-CSF restored mitochondrial membrane potential and total sperm motility in mice with macrophage Usp2 deficiency.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

PD-1 Deficiency Promotes Macrophage Activation and T-Helper Cell Type 1/T-Helper Cell Type 17 Response in Pneumocystis Pneumonia

Chao Zhang et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Article Reproductive Biology

Niclosamide suppresses macrophage-induced inflammation in endometriosis

Nikola Sekulovski et al.

BIOLOGY OF REPRODUCTION (2020)

Article Cell Biology

Isolation of functional mature peritoneal macrophages from healthy humans

Antonio J. Ruiz-Alcaraz et al.

IMMUNOLOGY AND CELL BIOLOGY (2020)

Article Immunology

IL-17A Modulates Peritoneal Macrophage Recruitment and M2 Polarization in Endometriosis

Jessica E. Miller et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Endocrinology & Metabolism

Endometriosis-Associated Macrophages: Origin, Phenotype, and Function

Chloe Hogg et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Obstetrics & Gynecology

Abnormal Expression of Indoleamine 2, 3-Dioxygenase in Human Recurrent Miscarriage

Hongxia Wei et al.

REPRODUCTIVE SCIENCES (2020)

Article Cell Biology

Macrophage Immune Memory Controls Endometriosis in Mice and Humans

Mohamed Jeljeli et al.

CELL REPORTS (2020)

Article Medicine, General & Internal

Intrauterine CRH-treated PBMC in repeated implantation failure

Antonis Makrigiannakis et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Obstetrics & Gynecology

Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP- in peritoneal macrophages

Qi Xie et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2019)

Article Cell Biology

Galectin-3 plays an important role in endometriosis development and is a target to endometriosis treatment

Romulo Medina de Mattos et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

Review Immunology

The Metabolic Signature of Macrophage Responses

Antonella Viola et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

Macrophage Polarization in Physiological and Pathological Pregnancy

Yongli Yao et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Developmental Biology

Elevated heme impairs macrophage phagocytosis in endometriosis

Yu-Yin Liu et al.

REPRODUCTION (2019)

Article Endocrinology & Metabolism

Reduced expression of PD-L1 in autoimmune thyroiditis attenuate trophoblast invasion through ERK/MMP pathway

Mengya Chen et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2019)

Article Obstetrics & Gynecology

The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy

Yonghong Zhang et al.

HUMAN REPRODUCTION (2019)

Article Obstetrics & Gynecology

Analysis of chromosome microstructures in products of conception associated with recurrent miscarriage

Taisuke Sato et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2019)

Article Biochemistry & Molecular Biology

Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages

Ping Yang et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2018)

Article Immunology

IL-33/ST2 axis affects the polarization and efferocytosis of decidual macrophages in early pregnancy

Yan-Ran Sheng et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2018)

Article Obstetrics & Gynecology

Immunology of endometriosis

Luiza da Gama Coelho Riccio et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2018)

Review Obstetrics & Gynecology

Implantation failure of endometrial origin: what is new?

Jose Bellver et al.

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY (2018)

Article Biochemistry & Molecular Biology

PPARγ Expression Is Diminished in Macrophages of Recurrent Miscarriage Placentas

Theresa Maria Kolben et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Endocrinology & Metabolism

Sympathetic innervation regulates macrophage activity in rats with polycystic ovary

Florencia Figueroa et al.

JOURNAL OF ENDOCRINOLOGY (2018)

Article Immunology

Characterization of myeloid cell populations in human testes collected after sex reassignment surgery

Rosalie Ponte et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2018)

Review Obstetrics & Gynecology

A search for molecular mechanisms underlying male idiopathic infertility

An Bracke et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2018)

Review Cell Biology

Microenvironmental signals govern the cellular identity of testicular macrophages

Andreas Meinhardt et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2018)

Article Multidisciplinary Sciences

Single-cell reconstruction of the early maternal-fetal interface in humans

Roser Vento-Tormo et al.

NATURE (2018)

Article Medicine, Research & Experimental

MIF May Participate in Pathogenesis of Polycystic Ovary Syndrome in Rats through MAPK Signalling Pathway

Dan-ni Zhou et al.

CURRENT MEDICAL SCIENCE (2018)

Article Genetics & Heredity

Chemokine (C-C motif) ligand-2 (CCL2) and oxidative stress markers in recurrent pregnancy loss and repeated implantation failure

Muberra Namli Kalem et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2017)

Review Immunology

The unique immunological and microbial aspects of pregnancy

Gil Mor et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Immunology

Role of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase in Patients with Recurrent Miscarriage

Yuki Obayashi et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2016)

Article Medicine, General & Internal

Polycystic Ovary Syndrome

Christopher R. McCartney et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Specification of tissue-resident macrophages during organogenesis

Elvira Mass et al.

SCIENCE (2016)

Article Medicine, General & Internal

Repeated implantation failure: a new potential treatment option

Antonis Makrigiannakis et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Cell Biology

Macrophages Contribute to the Spermatogonial Niche in the Adult Testis

Tony DeFalco et al.

CELL REPORTS (2015)

Review Cell Biology

Chemerin/chemR23 axis in inflammation onset and resolution

Francesco Mariani et al.

INFLAMMATION RESEARCH (2015)

Article Developmental Biology

Role of macrophage secretions on rat polycystic ovary: its effect on apoptosis

Florencia Figueroa et al.

REPRODUCTION (2015)

Article Immunology

Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization

Yuli Lin et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2014)

Article Medicine, Research & Experimental

Estrogen promotes Leydig cell engulfment by macrophages in male infertility

Wanpeng Yu et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Developmental Biology

Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage

Shinobu Goto et al.

MOLECULAR HUMAN REPRODUCTION (2014)

Review Endocrinology & Metabolism

Endometriosis: pathogenesis and treatment

Paolo Vercellini et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Article Multidisciplinary Sciences

Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis

Tony DeFalco et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Cell Biology

The importance of the macrophage within the human endometrium

Uma Thiruchelvam et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

Article Multidisciplinary Sciences

Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages

Mario Henrique M. Barros et al.

PLOS ONE (2013)

Review Reproductive Biology

Rodent Models for Human Polycystic Ovary Syndrome

Kirsty A. Walters et al.

BIOLOGY OF REPRODUCTION (2012)

Article Obstetrics & Gynecology

Adenomyosis is a potential cause of recurrent implantation failure during IVF treatment

Kelton Tremellen et al.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2011)

Article Obstetrics & Gynecology

Low-grade chronic inflammation in the peripheral blood and ovaries of women with polycystic ovarian syndrome

Yong-lao Xiong et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2011)

Article Immunology

Two Unique Human Decidual Macrophage Populations

Brandy L. Houser et al.

JOURNAL OF IMMUNOLOGY (2011)

Review Endocrinology & Metabolism

Polycystic ovary syndrome: etiology, pathogenesis and diagnosis

Mark O. Goodarzi et al.

NATURE REVIEWS ENDOCRINOLOGY (2011)

Review Endocrinology & Metabolism

Pituitary-ovary-spleen axis in ovulation

Oliver R. Oakley et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2011)

Article Biochemistry & Molecular Biology

Elevated circulating levels of macrophage migration inhibitory factor in polycystic ovary syndrome

Frank Gonzalez et al.

CYTOKINE (2010)

Article Endocrinology & Metabolism

Periovulatory Leukocyte Infiltration in the Rat Ovary

Oliver R. Oakley et al.

ENDOCRINOLOGY (2010)

Article Obstetrics & Gynecology

High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners

Christel Meuleman et al.

FERTILITY AND STERILITY (2009)

Article Obstetrics & Gynecology

Programming of human monocytes by the uteroplacental environment

Ramsey H. McIntire et al.

REPRODUCTIVE SCIENCES (2008)

Article Genetics & Heredity

Recurrent implantation failure: definition

John Rinehart

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2007)

Article Immunology

Regulating immunity to malaria

EM Riley et al.

PARASITE IMMUNOLOGY (2006)

Article Obstetrics & Gynecology

Investigation and current management of recurrent IVF treatment failure in the UK

BK Tan et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2005)

Article Obstetrics & Gynecology

Number, distribution pattern, and identification of macrophages in the testes of infertile men

MB Frungieri et al.

FERTILITY AND STERILITY (2002)

Article Biochemistry & Molecular Biology

Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia

T Nishioku et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Endocrinology & Metabolism

The endocrinology of menstruation - a role for the immune system

HOD Critchley et al.

CLINICAL ENDOCRINOLOGY (2001)

Article Reproductive Biology

Production of 25-hydroxycholesterol by testicular macrophages and its effects an Leydig cells

YO Lukyanenko et al.

BIOLOGY OF REPRODUCTION (2001)

Article Immunology

M-1/M-2 macrophages and the Th1/Th2 paradigm

CD Mills et al.

JOURNAL OF IMMUNOLOGY (2000)

Article Biochemistry & Molecular Biology

Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures

HJ Lin et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)