Case report: Pragmatic impairment in multiple sclerosis after worsening of clinical symptoms

Pragmatics, defined as the ability to integrate language and context to communicate effectively, may be impaired in Multiple Sclerosis (MS). We present the case of a patient with active secondary progressive MS who, after a first neuropsychological assessment that evidenced only a slight pragmatic impairment, suffered a sudden worsening of her clinical conditions, treated with corticosteroids. After this clinical worsening, her pragmatic abilities declined markedly, both in comprehension and production. This worsening was accompanied by a decline only in one attention task, in the context of an overall stable cognitive functioning. We conclude that pragmatics may be a domain particularly susceptible to cognitive worsening, highlighting the importance of its assessment in clinical practice.

Automated summary

Pragmatics, the ability to integrate language and context for effective communication, may be impaired in Multiple Sclerosis (MS). This article presents the case of an active secondary progressive MS patient whose pragmatic abilities declined markedly after receiving corticosteroid treatment.