Journal
JOURNAL OF SHOULDER AND ELBOW SURGERY
Volume 25, Issue 1, Pages 2-11Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jse.2015.09.018
Keywords
Shoulder arthroscopy; rotator cuff; leucocyte and platelet-rich fibrin (L-PRF); platelet-rich concentrates
Categories
Funding
- European Society for Surgery of the Shoulder and Elbow
- Societe Europeenne pour la Chirurgie de l'Epaule et du Coude (SECEC) Research Grant
- Swiss Society of Orthopedic Surgery and Traumatology
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Background: Because the retear rate after rotator cuff repairs remains high, methods to improve healing are very much needed. Platelet-rich concentrates have been shown to enhance tenocyte proliferation and promote extracellular matrix synthesis in vitro; however, their clinical benefit remains unclear. We hypothesized that arthroscopic rotator cuff repair with leucocyte-and platelet-rich fibrin (L-PRF) results in better clinical and radiographic outcome at 12 months of follow-up than without L-PRF. Methods: Thirty-five patients were randomized to receive arthroscopic rotator cuff repair with L-PRF locally applied to the repair site (L-PRF_group, n = 17) or without L-PRF (L-PRF+ group, n = 18). Preoperative and postoperative clinical evaluation included the Subjective Shoulder Value, visual analog score for pain, Simple Shoulder Test, and Constant-Murley score. The anatomic watertight healing, tendon thickness, and tendon quality was evaluated using magnetic resonance arthrography at 12 months of follow-up. Results: No complications were reported in either group. The mean Subjective Shoulder Value, Simple Shoulder Test, and Constant-Murley scores increased from preoperatively to postoperatively, showing no significant differences between the groups. Complete anatomic watertight healing was found in 11 of 17 in the L-PRF+ group and in 11 of 18 in the L-PRP+ group (P = .73). The mean postoperative defect size (214 +/- 130 mm(2) in the L-PRF+ group vs 161 +/- 149 mm(2) in the L-PRF+ group; P = .391) and the mean postoperative tendon quality according to Sugaya (L-PRF+ group: 3.0 +/- 1.4, L-PRF+ group: 3.0 +/- 0.9) were similar in both groups at 12 months of follow-up. Conclusion: Arthroscopic rotator cuff repair with application of L-PRF yields no beneficial effect in clinical outcome, anatomic healing rate, mean postoperative defect size, and tendon quality at 12 months of follow-up. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of Journal of Shoulder and Elbow Surgery Board of Trustees.
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